Acquired palsy of the oculomotor, trochlear and abducens nerves

Tiffin, Peter; MacEwen, C J; Craig, E A; Clayton, Gill

doi:10.1038/eye.1996.77

Cited by 129 publications

(95 citation statements)

References 12 publications

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“…Literatürdeki bazı araştırmalarda en sık izole 6. kraniyal sinir paralizisi saptanırken, 4,20,21 bazılarında daha çok 3. sinir paralizisi olduğu rapor edilmiş-tir. 5,22,23 Bizim serimizde, %48,9 oranında en sık izole 6. sinir paralizisi gözlenmiştir.…”

Section: Discussionunclassified

Ocular Motor Nerve Palsies: Clinical and Etiological Analysis

Nalçacioğlu¹,

Kavuncu²,

Budakoglu³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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Ö ÖZ ZE ET T A Am ma aç ç: : Oküler motor kraniyal sinir paralizisi olan hastaların etiyolojik ve klinik seyrinin retrospektif olarak değerlendirilmesidir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmamıza, Ulucanlar Göz Eğitim ve Araştırma Hastanesi Nörooftalmoloji Bölümüne 2003-2013 yılları arasında ardışık başvuran, düzenli takipleri olan 98 hasta dâhil edildi. Tüm hastaların ayrıntılı tıbbi öyküleri alındı, nörooftalmolojik muayeneleri yapıldı. Hastaların yaşı, cinsiyeti, eşlik eden sistemik hastalıkları, etiyolojisi, pupil çapı, pitozis varlığı ve şiddeti ve Hess ekranı ile değerlendirilen göz hareketleri geriye dönük olarak değerlendirildi. Etiyolojiye yönelik olarak görüntüleme yöntemlerine başvuruldu. B Bu ul lg gu ul la ar r: : Hastaların 45 (%45,9)'i kadın, 53 (%54,1)'ü erkek idi. Başvuru anındaki yaş ortalaması 53,6±17,5 (7-90) yıl idi. Ortalama izlem süresi 6,6±8,1 (3-64) ay idi. Her iki göz tutulumu 5 (%5,1) hastada mevcuttu. En sık izole altıncı kraniyal sinir (%48,9) felci izlenirken, bunu izole üçüncü kraniyal sinir (%34,6) felci izledi. İzole troklear sinir felci ise %15,3 oranında saptandı. Birden çok oküler motor sinir tutulumu ise 2 (%2,0) hastada izlendi. Oküler motor sinir felci ile pitoz %76,4 ve anizokori %17,6 oranında birliktelik göstermekte idi. Etiyolojik dağılımda hem altıncı sinir hem üçüncü kraniyal sinir için vaskü-ler sebepler (sırasıyla %68,7; %63,8), dördüncü kraniyal sinir felcinde ise kafa travması (%37,5) ön planda idi. S So on nu uç ç: : Bizim serimizde, oküler motor kraniyal sinir paralizilerinden en sık altıncı kraniyal sinir felci saptanırken, vasküler sebepler etiyolojik dağılımda ön planda idi. Imaging methods were used as required to determine the etiology. R Re es su ul lt ts s: : There were 45 (45.9%) female and 53 (54.1%) male patients. The mean age at presentation was 53.6±17.5 (7-90) years. The mean follow-up period was 6.6±8.1 (3-64) months. Five (5.1%) cases had bilateral involvement. The most commonly affected nerve was the sixth cranial nerve (48.9%) followed by the third cranial nerve (34.6%). Trochlear nerve palsy was identified at a rate of 15.3%. Multiple ocular nerve palsies were observed in 2 (2.0%) cases. Accompanying ptosis was found in 76.4% and anisocoria in 17.6%. The main cause was vascular disorders for both sixth and third cranial nerve palsy (68.7% and 63.8%, respectively) and head trauma for fourth cranial nerve palsy (37.5%). C Co on nc cl lu us si io on n: : Sixth cranial nerve palsy was the most common ocular motor cranial nerve palsy and a vascular disorder was the most frequent cause of these disorders.

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Section: Discussionunclassified

Ocular Motor Nerve Palsies: Clinical and Etiological Analysis

Nalçacioğlu¹,

Kavuncu²,

Budakoglu³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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“…1 However, other studies showed variety in the aetiology and affected nerve distribution and wide range of recovery rates. [1][2][3][4][5][6] The recovery from cranial nerve palsy is thought to have to do with its aetiology, but there have been rare attempts to identify the factors affecting recovery. 1,[4][5][6] We therefore performed this retrospective study to analyse the clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy and identify the factors affecting its recovery.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy

et al. 2007

Eye

123

114

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Purpose Clinical features of acquired third, fourth, and sixth cranial nerve palsy showed variation among previous studies. Evaluation of natural course with objective criteria will establish accurate recovery rates and important factors for recovery. Methods Retrospective chart review was performed on 206 patients who visited a neuro-ophthalmic department with acquired third, fourth, and sixth nerve palsy. Aetiology and results of ocular exam on each visit were reviewed, and multivariate logistic regression analysis was performed to identify independent factors affecting recovery. Results The sixth cranial nerve was affected most frequently (n ¼ 108, 52.4%) and vascular disease (n ¼ 64, 31.1%) was the most common aetiology. Recovery was evaluated with change of deviation angle for 108 patients, who were first examined within a month of onset and followed up for at least 6 months. Ninety-two (85.2%) patients showed overall (at least partial) recovery and 73 (67.6%) showed complete recovery. In univariate analysis, initial deviation angle was found to be only significant factor associated with complete recovery (P ¼ 0.007) and most patients who experienced successful management of treatable underlying disease showed recovery. Conclusions With objective criteria based on deviation angle, overall recovery rate from the third, fourth, and sixth nerve palsy was 85.2%. Patients who had smaller initial eyeball deviation or successful management of treatable underlying disease had a high chance of recovery.

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“…[81][82][83][84] They are often isolated events causing acute symptomatic diplopia. 85 They usually resolve spontaneously within three months.…”

Section: Non-arteritic Anterior Ischaemic Optic Neuropathymentioning

confidence: 99%

Hypertension and the eye: changing perspectives

et al. 2002

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Systemic hypertension is a common condition associated with significant morbidity and mortality. Hypertension confers cardiovascular risk by causing target-organ damage that includes retinopathy in addition to heart disease, stroke, renal insufficiency and peripheral vascular disease. The recognition of hypertensive retinopathy is important in cardiovascular risk stratification of hypertensive individuals. This review reevaluates the changing perspectives in the pathophysiology, classification and prognostic significance of fundal lesions in hypertensives.

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Acquired palsy of the oculomotor, trochlear and abducens nerves

Cited by 129 publications

References 12 publications

Ocular Motor Nerve Palsies: Clinical and Etiological Analysis

Ocular Motor Nerve Palsies: Clinical and Etiological Analysis

Clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy

Hypertension and the eye: changing perspectives

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