Acquired disaccharide intolerance in children with malnutrition

Bilir, Sule

doi:10.1093/ajcn/25.7.664

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…This leads to the stimulation of duodenal osmoreceptors (Elias et al, 1968). We can suggest a similar mechanism as disaccharidases, especially lactase, were reported deficient in PEM, thus lactose would stimulate the osmoreceptors in a manner similar to that by glucose (Dahlqvist and Lindquist, 1971;Bilir, 1972).…”

Section: Discussionsupporting

confidence: 55%

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

et al. 2004

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Objective and Design: The earlier reports of disturbed gastric motility in protein energy malnutrition (PEM) point out to its possible contribution in the difficulties faced during nutritional rehabilitation. This study was thus designed to assess the ultrasonographic gastric emptying time (GET) using 20 ml/kg body weight of both liquid and semisolid meals, in 27 patients suffering from PEM as well as in 15 healthy matching infants to delineate any defect present, its degree in different types of PEM and the effect of nutritional rehabilitation. Patients: The patients were recruited from the in-patient department of Children's Hospital, Ain Shams University, Cairo, Egypt. They were divided into three groups: 10 marasmic infants, 10 marasmic kwashiorkor (marasmic KWO) and seven kwashiorkor (KWO) cases. Ultrasonographic GET assessment was carried out within 72 h of admission and 3077 days after nutritional rehabilitation. Results: The gastric half-emptying time T(1/2) of both liquid and semisolid meals was markedly prolonged in patients with marasmus and marasmic KWO. It was more delayed for the semisolid than the liquid meals. This delay was reversible after nutritional rehabilitation of the patients, indicating that it was secondary to the malnourished status. On the other hand, T(1/2) of both liquid and semisolid meals showed no statistically significant delay in the KWO group and nutritional rehabilitation added no further to the results. Conclusion: PEM, especially marasmus and marasmic KWO, causes a delay in GET, which is reversible on nutritional recovery. This must be considered during nutritional rehabilitation of such patients to decrease the duration of their hospitalization and thus decrease the morbidity in PEM. Sponsorship: This study was supported by a university fund from

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Section: Discussionsupporting

confidence: 55%

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

et al. 2004

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“…Children with SAM, when compared with controls, showed a decline in the average maximum glucose rise. 18–20 Habte et al . 21 demonstrated a significant rise in the concentration of blood glucose in malnourished children after administration of glucose + galactose, and sucrose, but not after administration of lactose.…”

Section: Resultsmentioning

confidence: 99%

“…(1971) 26 SAM a No 10 Lactose 2 24.5 ± 16.5* – – – Glucose + galactose 1 + 1 27.9 ± 23.04* – – – James (1972) 17 MAM and SAM a Yes 8 Lactose 2 38.5 ± 22.61* – 28.75 ± 17.5* – Sucrose 2 42.5 ± 29.35* – 51.57 ± 12.46* – Bilir. (1972) 18 MAM and SAM a Yes 12 Lactose 2 14.5 (8–44) 49 (48–75) – – Glucose + galactose 2 47.9 (36–68) 53.8 (60–68) – – Viteri et al. (1973) 22 Kwashiorkor Yes 16 …”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 3 , reduced fecal pH was observed in children with SAM compared with controls in the studies that conducted carbohydrate tolerance tests, although the average pH was still more than 5.5 in all malnourished cohorts studied. 18–20 In particular, Kerpel-Fornius et al . 19 showed, in both SAM subjects and controls, a higher fecal pH in both the galactose + glucose and the sucrose tolerance tests than in the lactose tolerance test.…”

Section: Resultsmentioning

confidence: 99%

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Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review

Kvissberg¹,

Dalvi²,

Kerac³

et al. 2015

Nutr Rev

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Context: Severe acute malnutrition (SAM) accounts for approximately 1 million child deaths per year. High mortality is linked with comorbidities, such as diarrhea and pneumonia. Objective: The aim of this systematic review was to determine the extent to which carbohydrate malabsorption occurs in children with SAM. Data Sources: The PubMed and Embase databases were searched. Reference lists of selected articles were checked. Data Extraction: All observational and controlled intervention studies involving children with SAM in which direct or indirect measures of carbohydrate absorption were analyzed were eligible for inclusion. A total of 20 articles were selected for this review. Data Synthesis: Most studies reported carbohydrate malabsorption, particularly lactose malabsorption, and suggested an increase in diarrhea and reduced weight gain in children on a lactose-containing diet. As most studies reviewed were observational, there was no conclusive scientific evidence of a causal relationship between lactose malabsorption and a worse clinical outcome among malnourished children. Conclusion: The combined data indicate that carbohydrate malabsorption is prevalent in children with SAM. Additional well-designed intervention studies are needed to determine whether outcomes of SAM complicated by carbohydrate malabsorption could be improved by altering the carbohydrate/lactose content of therapeutic feeds and to elucidate the precise mechanisms involved.

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“…A proteína do leite, devido ao seu alto valor biológico e boa aceitação, parece ser a preferida. Entretanto, a intolerância aos dissacáridos, observada em alguns graus de desnutrição (BILIR, 1972), às vezes impede o seu uso. Nessas circunstâncias, utilizam-se outras proteínas sobretudo de origem vegetal.…”

Section: Introductionunclassified

Estudo Da Desnutrição Proteica E Calórica Em Ratos 1 — Alterações Ponderais De Alguns Órgãos De Animais Recuperados Com Caseína E Carne

Mattos¹,

Salum²,

Shima³

et al. 1975

Rev. esc. enferm. USP

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Os autores estudaram a recuperação de animais com desnutrição proteica ou calórica, com proteína da caseína ou da carne. Observaram que os animais submetidos à dieta restrita em caloria recuperaram-se bem, apresentando um índice de sobrevivência de 100% tanto os recuperados com carne como os com a caseína. Por outro lado, dos animais com depleção proteica, sobreviveram apenas os recuperados com caseína, tendo havido entre os alimentados com carne uma mortalidade de 50%. Em qualquer dos grupos, os animais alimentados com carne cresceram mais, mas em nenhum grupo os animais atingiram o peso médio dos do grupo controle. Os órgãos dos animais, com deficiência proteica anterior e recuperados com carne, desenvolveram-se mais rapidamente que os dos outros grupos, exceto o pancreas.

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Acquired disaccharide intolerance in children with malnutrition

Cited by 10 publications

References 23 publications

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

Ultrasonographic gastric emptying in protein energy malnutrition: effect of type of meal and nutritional recovery

Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review

Estudo Da Desnutrição Proteica E Calórica Em Ratos 1 — Alterações Ponderais De Alguns Órgãos De Animais Recuperados Com Caseína E Carne

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