Acid Attack and Cathepsin K in Bone Resorption Around Total Hip Replacement Prosthesis

Konttinen, Yrjö T.; Takagi, Michiaki; Mandelin, Jami; Lassus, Jan; Salo, Jari; Ainola, Mari; Li, Tian-Fang; Virtanen, Ismo; Liljeström, Mikko; Sakai, Hideaki; Kobayashi, Yasuhiro; Sorsa, Timo; Lappalainen, Reijo; Demulder, Anne; Santavirta, Seppo

doi:10.1359/jbmr.2001.16.10.1780

Cited by 103 publications

(125 citation statements)

References 35 publications

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“…Furthermore, a higher number of TRAP positive cells was seen in the synovium of the experimental group but few cells or none were seen in the control group. Histochemistry for TRAP produced results was consistent with those of an earlier study which reported an increase in the number of TRAP + cells in the synovium from humans with arthritis and dogs with osteoarthritis secondary to the naturally occurring rupture of the cranial cruciate ligament (Konttinen et al, 2001;Muir et al, 2005). These results suggest that an increase in the number of TRAP + cells in the synovium is related to the development of OA.…”

Section: Discussionsupporting

confidence: 89%

Tartrate-resistant acid phosphatase, matrix metalloproteinase-2 and tissue inhibitor metalloproteinase-2 in early stages of canine osteoarthritis

Lee¹,

Alam²,

Seol³

et al. 2008

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine if the activity of tartrate-resistant acid phosphatase (TRAP) in the synovial fluid (SF) and serum can be used as a marker for diagnosing the early stages of osteoarthritis (OA). We also wished to determine if identifiable differences in the concentrations of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) could be detected in SF between normal joints and OA joints for the diagnosis of early OA. Ten skeletally mature beagle dogs underwent a unilateral surgical transection of the cranial cruciate ligament and medial meniscectomy. Five sham-operated beagle dogs were used as controls. The synovial fluid was collected in 1, 2 and 3 months and examined by western blotting for MMP-2 and ELISA for TIMP-2. The activity of TRAP in the SF and serum was measured using a spectrophotometer. In addition, the presence of TRAP positive cells in the synovium was identified by enzyme histochemistry. The level of the activity of TRAP and MMP-2 in the SF from the induced OA dogs was significantly higher than that of the control over a three-month period (P < 0.05). The TIMP-2 level in the SF was significantly lower in the induced OA dogs than in the control. However, there was no difference in TRAP activity in the serum. Histochemistry revealed a higher number of TRAP positive cells in the synovium from the induced OA dogs. Based on these data, we conclude that the activity of TRAP, MMP-2 and TIMP-2 in SF can be used as a biomarker to diagnose and monitor the early stages of OA.Keywords: tartrate-resistant acid phosphatase; matrix metalloproteinase-2; tissue inhibitor of matrix metalloproteinase-2; osteoarthritis; synovial fluid Supported by the Second Stage Brain Korea (BK) 21 Project and the Korea Science and Engineering Foundation

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Section: Discussionsupporting

confidence: 89%

Tartrate-resistant acid phosphatase, matrix metalloproteinase-2 and tissue inhibitor metalloproteinase-2 in early stages of canine osteoarthritis

Lee¹,

Alam²,

Seol³

et al. 2008

Vet. Med. - Czech

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“…Rapidly destroyed autologous tissue (debris) in vasculitic diseases may fulfil this requirement. Finally, low pH triggers formation of polykaryons, as has been described around loosening implants [50]. Cell fusion has some important requirements: cell accumulation (density), cell adhesion and aggregation (contact) and membrane fusion (polykaryon formation by fusion).…”

Section: Dna Microarray Datamentioning

confidence: 92%

“…Thus, it seems that monocyte/macrophages, primed by indigestible particulate matter, require 'regulatory' costimulation by extracellular matrix, LPS and other exogenous soluble, cell-mediated or mechanical stimuli for fullscale activation and/or differentiation. in highly lytic lesions such as osteoclastomas [49] and aseptic loosening of hip implants [50]. Fusion can occur under the influence of either Th2 or Th1 cytokines.…”

Section: Dna Microarray Datamentioning

confidence: 99%

Regulation of macrophage activation

Chen

Mandelin

et al. 2003

Cellular and Molecular Life Sciences (CMLS)

302

234

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IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNgamma or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis. If instead it is driven by Th2 cytokines interleukin (IL)-4 and IL-13, it undergoes alternate type 2 activation, which enhances endocytotic antigen uptake and presentation, mast cell and eosinophil involvement and type 2 granuloma formation, e.g. in response to parasitic and extracellular pathogens. Particle-induced macrophage activation was shown to differ from classical and alternate activation, showing in DNA microarray experiments (complete linkage/ Euclidean distance metric analysis) upregulation of nonsecreted structural/signaling molecules and lack of secreted proinflammatory cyto- and chemokines. The switch-off (deactivation) of already activated macrophages is an active, controlled process in which IL-10 and corticosteroids play important roles and to which 15dPGJ2, PGA1/2 and vasoactive intestinal peptide often contribute.

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“…On implantation, the pH of the tissue surrounding the implant may decrease to values around 5, and then recover to 7.4 within weeks [23]. Local variations in pH value have been measured in periprosthetic tissue of revised hip implants [24,25]. Recurrence of pain in patients with cemented Mü ller straight femoral stems of Ti forged alloy was ascribed to the high acidity initiating crevice corrosion [24].…”

Section: The Human Body As a Corrosive Environmentmentioning

confidence: 99%

Special modes of corrosion under physiological and simulated physiological conditions

et al. 2008

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Acid Attack and Cathepsin K in Bone Resorption Around Total Hip Replacement Prosthesis

Cited by 103 publications

References 35 publications

Tartrate-resistant acid phosphatase, matrix metalloproteinase-2 and tissue inhibitor metalloproteinase-2 in early stages of canine osteoarthritis

Tartrate-resistant acid phosphatase, matrix metalloproteinase-2 and tissue inhibitor metalloproteinase-2 in early stages of canine osteoarthritis

Regulation of macrophage activation

Special modes of corrosion under physiological and simulated physiological conditions

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