Acetolactate Synthase Inhibitors

Shimizu, Tsutomu; Nakayama, Ishizue; Nagayama, Kozo; Miyazawa, Takeshige; Nezu, Yukio

doi:10.1007/978-3-642-59416-8_1

Cited by 57 publications

(49 citation statements)

References 141 publications

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“…ALS is the primary target site for at least four classes of herbicides: sulfonylurea, imidazolinone, pyrimidinyl carboxylates, and triazolopyrimidine herbicides (Shimizu et al, 2002(Shimizu et al, , 2005. These herbicides can inhibit ALS activity, resulting in plant death caused by a deficiency of branched-chain amino acids.…”

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“…Bispyribac sodium (BS), a pyrimidinyl carboxylate herbicide, is effective in controlling many annual and perennial weeds, with excellent selectivity on directseeded rice (Shimizu et al, 2002). Recently, it was reported that japonica rice varieties show higher sensitivity to BS compared with indica rice varieties at the early stages of plant growth (Ohno et al, 2008;Taniguchi et al, 2010).…”

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A Novel Rice Cytochrome P450 Gene, CYP72A31, Confers Tolerance to Acetolactate Synthase-Inhibiting Herbicides in Rice and Arabidopsis

et al. 2014

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Target-site and non-target-site herbicide tolerance are caused by the prevention of herbicide binding to the target enzyme and the reduction to a nonlethal dose of herbicide reaching the target enzyme, respectively. There is little information on the molecular mechanisms involved in non-target-site herbicide tolerance, although it poses the greater threat in the evolution of herbicide-resistant weeds and could potentially be useful for the production of herbicide-tolerant crops because it is often involved in tolerance to multiherbicides. Bispyribac sodium (BS) is an herbicide that inhibits the activity of acetolactate synthase. Rice (Oryza sativa) of the indica variety show BS tolerance, while japonica rice varieties are BS sensitive. Map-based cloning and complementation tests revealed that a novel cytochrome P450 monooxygenase, CYP72A31, is involved in BS tolerance. Interestingly, BS tolerance was correlated with CYP72A31 messenger RNA levels in transgenic plants of rice and Arabidopsis (Arabidopsis thaliana). Moreover, Arabidopsis overexpressing CYP72A31 showed tolerance to bensulfuron-methyl (BSM), which belongs to a different class of acetolactate synthase-inhibiting herbicides, suggesting that CYP72A31 can metabolize BS and BSM to a compound with reduced phytotoxicity. On the other hand, we showed that the cytochrome P450 monooxygenase CYP81A6, which has been reported to confer BSM tolerance, is barely involved, if at all, in BS tolerance, suggesting that the CYP72A31 enzyme has different herbicide specificities compared with CYP81A6. Thus, the CYP72A31 gene is a potentially useful genetic resource in the fields of weed control, herbicide development, and molecular breeding in a broad range of crop species.

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A Novel Rice Cytochrome P450 Gene, CYP72A31, Confers Tolerance to Acetolactate Synthase-Inhibiting Herbicides in Rice and Arabidopsis

et al. 2014

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“…Worldwide, herbicides inhibiting acetolactatesynthase (ALS) are the most used ones at present. ALS is the primary target site of action for five structurally distinct classes of herbicides including pyrimidinylthiobenzoates, sulfonylureas, imidazolinones, triazolopyrimidine sulfonamides and sulfonylaminocarbonyltriazolinones (Shimizu et al, 2002).…”

Section: Weed Resistance To Acetolactate Synthase-inhibiting Herbicidesmentioning

confidence: 99%

Weed Resistance to Herbicides in the Czech Republic: History, Occurrence, Detection and Management

Hamouzová¹,

Salava²,

Soukup³

et al. 2011

Herbicides - Mechanisms and Mode of Action

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“…Although ALS functions in plastids, ALS is a dominant and nuclear gene, and thus follows normal Mendelian inheritance. ALS is the target enzyme of at least five structurally distinct classes of herbicides; pyrimidinylcarboxylates (PCs), sulfonylureas (SUs), imidazolinones (IMs), triazolopyrimidine sulfonamides and sulfonylaminocarbonyltriazolinones (Shimizu et al, 2002). These herbicides all bind to ALS, but not all at the same attachment points.…”

Section: Introductionmentioning

confidence: 99%