Acetaldehyde Production and Other ADH‐Related Characteristics of Aerobic Bacteria Isolated From Hypochlorhydric Human Stomach

Väkeväinen, Satu; Tillonen, Jyrki; Blom, Mikko; Jousimies‐Somer, Hannele; Salaspuro, Mikko

doi:10.1111/j.1530-0277.2001.tb02230.x

Cited by 27 publications

(10 citation statements)

References 37 publications

(37 reference statements)

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“…were very high in the alcoholics' saliva, and the number of a-hemolytic Streptococci was significantly reduced after hospitalization. It is conceivable that these predominant bacteria, whose ability to produce acetaldehyde is not very great, 30 substantially contribute to salivary acetaldehyde production. In addition to the overgrowth of these bacteria, enzyme induction in each strain or natural selection of high-ADH activity strains may occur because of chronic heavy ethanol exposure.…”

Section: Discussionmentioning

confidence: 99%

Contribution of the alcohol dehydrogenase‐1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men

Yokoyama

Tsutsumi

Imazeki

et al. 2007

Intl Journal of Cancer

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The less-active homozygous alcohol dehydrogenase-1B (ADH1B*1/ *1) and inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) increase the risk of upper aerodigestive tract cancer (UADTC) in Japanese alcoholics. We evaluated associations between ADH1B/ALDH2 genotypes and the blood and salivary ethanol/acetaldehyde levels of 80 Japanese alcoholic men in the morning when they first visited our hospital after drinking the day before. Higher levels of ethanol persisted in the blood for longer periods in ADH1B*1/*1 carriers (n 5 25) than in ADH1B*2 allele carriers after adjustment for the amount and time of the preceding alcohol consumption and body weight [median (25th-75th %): 20.5 mM (15.5-52.4) vs. below detection level (

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Section: Discussionmentioning

confidence: 99%

Contribution of the alcohol dehydrogenase‐1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men

Yokoyama

Tsutsumi

Imazeki

et al. 2007

Intl Journal of Cancer

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“…Various ALDH isoenzymes also exist in the gastric mucosa and exhibit different kinetic properties, preventing the local toxic effect of acetaldehyde by oxidizing it to acetate. The activity of this enzyme is much lower than alcohol dehydrogenase [3]. In our previous study, we found that gastric cancer (GC) tissue expresses ADH isoenzymes and ALDH activities.…”

Section: Introductionmentioning

confidence: 99%

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

et al. 2010

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Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in gastric cancer cells (GC). Moreover, the activity of total ADH and class IV isoenzymes is significantly higher in cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is probably reflected in the sera and could thus be helpful for diagnostics of gastric cancer. The aim of this study was to investigate a potential role of ADH and ALDH as tumor markers for gastric cancer. We defined diagnostic sensitivity, specificity, predictive value for positive and negative results, and receiver-operating characteristics (ROC) curve for tested enzymes. Serum samples were taken from 168 patients with gastric cancer before treatment and from 168 control subjects. Total ADH activity and class III and IV isoenzymes were measured by photometric but ALDH activity and ADH I and II by the fluorometric method, with class-specific fluorogenic substrates. There was significant increase in the activity of ADH IV isoenzyme and ADH total in the sera of gastric cancer patients compared to the control. The diagnostic sensitivity for ADH IV was 73%, specificity 79%, positive and negative predictive values were 81 and 72% respectively. Area under ROC curve for ADH IV was 0.67. The results suggest a potential role for ADH IV as marker of gastric cancer.

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“…This phenomenon may due to the increased ADH activity, which has been confirmed in Streptococcus gordonii V2016 (107), Neisseria (108) and Streptococcus salivarius (109), the prevalence of aerobic Gram-positive bacteria and yeast are important in acetaldehyde production (109), due to their increased ADH activity. Other species, including hemolytic Streptococcus viridans var., Stomatococcus sp.…”

Section: Interactions Between Alcohol Consumption and The Correspondimentioning

confidence: 90%

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

2016

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Abstract. Esophageal cancer is the eighth most common type of cancer in the world, and the sixth most common cause of mortality from cancer. Alcohol consumption is the major risk factor for esophageal cancer, due to the worldwide prevalence and high carcinogenicity of the ethanol metabolite. In epidemiological studies, the efficiency of alcohol intake to enhance the risk of esophageal cancer is altered by daily ethanol consumption, type of alcoholic beverages ingested, time since quitting drinking, age of drinking initiation, differences in population and subtypes of esophageal cancer. Corresponding factors, including gene polymorphisms, tobacco smoking, oral microorganisms and folate deficiency, reveal a synergistic effect in concurrent alcohol users that may lead to an increased risk of developing esophageal cancer. Consequently, esophageal cancer prevention involves multiple aspects, including quitting drinking and smoking, maintaining an adequate oral health and ingesting adequate quantities of folate, particularly in genetically high-risk populations.

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Acetaldehyde Production and Other ADH‐Related Characteristics of Aerobic Bacteria Isolated From Hypochlorhydric Human Stomach

Cited by 27 publications

References 37 publications

Contribution of the alcohol dehydrogenase‐1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men

Contribution of the alcohol dehydrogenase‐1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

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