The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

Jelski, Wojciech; Orywal, Karolina; Laniewska, Magdalena; Szmitkowski, Maciej

doi:10.1007/s10238-010-0097-2

Cited by 19 publications

(18 citation statements)

References 18 publications

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“…The results in the present paper are in agreement with other studies performed on the stomach (Jelski et al, 2010a). Our previous study demonstrated the potential importance of ADH IV as a marker of gastric cancer (GC).…”

Section: Discussionsupporting

confidence: 93%

The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.

Jelski

Laniewska-Dunaj²,

Nikliński³

et al. 2013

Acta Biochim Pol

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Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in esophageal cancer cells. Moreover the total activity of ADH as well as the activity of class IV ADH isoenzyme is significantly higher in cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is reflected in the sera and could thus be helpful for diagnostics of esophageal cancer. The aim of this study was to investigate a potential significance of ADH isoenzymes and ALDH as tumour markers of esophageal cancer. We defined diagnostic sensitivity, specificity, predictive value for positive and negative results, and receiver-operating characteristics (ROC) curve for tested enzymes. Serum samples were taken for routine biochemical investigation from 180 patients with esophageal cancer before treatment. Total ADH activity was measured by a photometric method with p-nitrosodimethylaniline as a substrate and ALDH activity by a fluorometric method with 6-methoxy-2-naphtaldehyde as a substrate. For the measurement of the activity of class I and II isoenzymes we employed the fluorometric methods, with class-specific fluorogenic substrates. The activity of class III alcohol dehydrogenase was measured by a photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate. There was a significant increase in the activity of class IV of ADH isoenzyme (7.65 mU/l vs 5.88 mU/l) and total ADH activity (1198 mU/l vs 848 mU/l) in the sera of esophageal cancer patients compared to the control. The diagnostic sensitivity for ADH IV was 72%, the specificity 76%, the positive and negative predictive values were 80% and 72% respectively. The area under the ROC curve for ADH IV was 0.65. The results suggest a potential significance of ADH IV as a marker of esophageal cancer.

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Section: Discussionsupporting

confidence: 93%

The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.

Jelski

Laniewska-Dunaj²,

Nikliński³

et al. 2013

Acta Biochim Pol

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“…Numerous studies have shown that the serum levels of class I ADH are a potential diagnostic marker in multiple cancers, including renal cell,20 brain,21 colorectal,22 endometrial,23 and cervical cancers 24. Similar diagnostic values can also be observed in class III ADH for pancreatic cancer,8 and class IV ADH for esophageal25 and gastric cancers 26. The diagnostic values of ADH isoenzymes in other cancers have not yet been reported, but the difference of ADH isoenzymes between cancer patients and healthy subjects has already been observed.…”

Section: Discussionsupporting

confidence: 63%

Distinct prognostic values of alcohol dehydrogenase mRNA expression in pancreatic adenocarcinoma

Liao¹,

Huang²,

Liu³

et al. 2017

OTT

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BackgroundAlcohol dehydrogenase (ADH) isoenzymes have been reported as a potential diagnostic marker for pancreatic cancer, but their prognostic value in pancreatic cancer remains unclear. The aim of this investigation was to identify the prognostic value of ADH genes in human patients with pancreatic adenocarcinoma (PAAD).Materials and methodsAn RNA sequencing dataset and corresponding survival profiles of PAAD were obtained from The Cancer Genome Atlas. Survival analysis and gene set enrichment analysis were used to investigate the prediction value and potential mechanism of ADH genes in PAAD prognosis.ResultsSurvival analysis of ADH genes suggests that a high expression of ADH1A (adjusted P=0.037, adjusted hazard ratio [HR] =0.627, 95% CI =0.404–0.972) and ADH6 (adjusted P=0.018, adjusted HR =0.588, 95% CI =0.378–0.914) were associated with a significantly decreased risk of death, while a high expression of ADH5 was associated with a significantly increased risk of death (adjusted P=0.043, adjusted HR =1.564, 95% CI =1.013–2.414). Joint effects analysis of three ADH gene prognostic markers suggests that the prognosis difference for any marker combination was more significant than that for any individual marker. The potential mechanism of ADH1A and ADH6 in PAAD prognosis was that a high expression of ADH1A and ADH6 was involved in the P450 pathway and biological processes, while high ADH5 expression was involved in transforming growth factor β regulation-related pathways and biological processes, Wnt, the cell cycle, ErbB, and mitogen-activated protein kinase signaling pathways.ConclusionOur data suggest that ADH1A, ADH5, and ADH6 expression may be potential prognostic markers of PAAD and in combination have a strong interaction and better predictive value for PAAD prognosis.

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“…The ADH isoenzymes generally refer to a metabolic barrier against orally self-administer ethanol and also against ethanol produced from carbohydrates through fermentation of bacterial [14], [15]. ADH1 and ADH2, two well-known members of ADH family, mainly expressed in the liver but also the gastric mucosa, is significantly responsible for the partially metabolism of orally ingested alcohol, namely, in the conversion of ethanol to its carcinogenic metabolite, acetaldehyde, particularly during the elimination phase [16]–[18].…”

Section: Introductionmentioning

confidence: 99%

“…Genetic variants in ALDH2/ADH1/ADH2 genes may contribute to alteration in alcohol metabolism which may resulting in the promotion of ethanol oxidation, and may be closely associated with the inhibition of acetaldehyde oxidation, conducing to the accumulation of acetaldehyde [14], [24], [25]. Therefore, it is hypothesized that genetic polymorphisms in the ALDH2/ADH1/ADH2 genes may be strongly correlated with the susceptibility to gastric cancer [16], [26], [27].…”

Section: Introductionmentioning

confidence: 99%

ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis

2014

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AimWe conducted a meta-analysis of case-control studies to determine whether ALDH2, ADH1 and ADH2 genetic polymorphisms contribute to the pathogenesis of gastric cancer.MethodsThe PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. We calculated crude odds ratios (ORs) with their 95% confidence intervals (95%CI) to evaluate their relationships under five genetic models. Seven case-control studies with a total of 2,563 gastric cancer patients and 4,192 healthy controls met the inclusion criteria. Nine common polymorphisms were evaluated, including rs671, rs16941667 and rs886205 in the ALDH2 gene, rs1230025, rs13123099, rs698 and rs1693482 in the ADH1 gene, and rs1229984 and rs17033 in the ADH2 gene.ResultsThe results of our meta-analysis suggested that ALDH2 genetic polymorphisms might be strongly correlated with an increased risk of gastric cancer (allele model: OR = 1.21, 95%CI: 1.11∼1.32, P<0.001; dominant model: OR = 1.23, 95%CI: 1.09∼1.39, P = 0.001; respectively), especially for rs671 polymorphism. Furthermore, we observed significant associations between ADH1 genetic polymorphisms and an increased risk of gastric cancer (allele model: OR = 1.21, 95%CI: 1.08∼1.36, P = 0.001; dominant model: OR = 10.52, 95%CI: 3.04∼36.41, P<0.001; respectively), especially for rs1230025 polymorphism. Nevertheless, no positive relationships were found between ADH2 genetic polymorphisms and gastric cancer risk (all P>0.05).ConclusionThe current meta-analysis suggests that ALDH2 and ADH1 genetic polymorphisms may play crucial roles in the pathogenesis of gastric cancer. However, ADH2 genetic polymorphisms may not be important dominants of susceptibility to gastric cancer.

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The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

Cited by 19 publications

References 18 publications

The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.

The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.

Distinct prognostic values of alcohol dehydrogenase mRNA expression in pancreatic adenocarcinoma

ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis

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