Acellular pertussis vaccines in China

Wang, Lichan; Lei, Dianliang; Zhang, Shumin

doi:10.1016/j.vaccine.2012.10.009

Cited by 30 publications

(18 citation statements)

References 13 publications

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“…Besides, an apparent cyclicity and seasonality was observed in the pertussis reporting. According to out-of-sample forecasting, the model forecasts a relatively high incidence cases in 2016, which predicates an increasing risk of ongoing pertussis resurgence in mainland China in the near future, indicating that pertussis never goes away completely3132.…”

Section: Discussionmentioning

confidence: 99%

Time series analysis of temporal trends in the pertussis incidence in Mainland China from 2005 to 2016

Zeng

Huang

et al. 2016

Sci Rep

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Short-term forecast of pertussis incidence is helpful for advanced warning and planning resource needs for future epidemics. By utilizing the Auto-Regressive Integrated Moving Average (ARIMA) model and Exponential Smoothing (ETS) model as alterative models with R software, this paper analyzed data from Chinese Center for Disease Control and Prevention (China CDC) between January 2005 and June 2016. The ARIMA (0,1,0)(1,1,1)12 model (AICc = 1342.2 BIC = 1350.3) was selected as the best performing ARIMA model and the ETS (M,N,M) model (AICc = 1678.6, BIC = 1715.4) was selected as the best performing ETS model, and the ETS (M,N,M) model with the minimum RMSE was finally selected for in-sample-simulation and out-of-sample forecasting. Descriptive statistics showed that the reported number of pertussis cases by China CDC increased by 66.20% from 2005 (4058 cases) to 2015 (6744 cases). According to Hodrick-Prescott filter, there was an apparent cyclicity and seasonality in the pertussis reports. In out of sample forecasting, the model forecasted a relatively high incidence cases in 2016, which predicates an increasing risk of ongoing pertussis resurgence in the near future. In this regard, the ETS model would be a useful tool in simulating and forecasting the incidence of pertussis, and helping decision makers to take efficient decisions based on the advanced warning of disease incidence.

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Section: Discussionmentioning

confidence: 99%

Time series analysis of temporal trends in the pertussis incidence in Mainland China from 2005 to 2016

Zeng

Huang

et al. 2016

Sci Rep

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“…Inactivated wholecell pertussis vaccines (WPVs) have been in use in national immunization program for many years and the mortality and morbidity of pertussis have been drastically reduced. [1][2][3] Although the safe and effective, WPVs could be associated with some serious adverse events. 4 These reactions, although without permanent sequelae, may alarm parents and affect compliance with subsequent vaccinations.…”

Section: Introductionmentioning

confidence: 99%

Characterization of co-purified acellular pertussis vaccines

Tan

Asokanathan

et al. 2015

Human Vaccines & Immunotherapeutics

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These authors contributed equally to this work.Keyword: Co-purified acellular pertussis vaccines, immune responses, protection, proteomic analysis Abbreviations: WPVs, whole-cell pertussis vaccines; APVs, acellular pertussis vaccines; PT, pertussis toxin; FHA, filamentous hemagglutinin; 2-DE, 2-dimensional gel electrophoresis; PRN, pertactin; FIM, fimbriae; BipA, putative outer membrane ligand binding protein; Sbp, sulfate-binding protein precursor; sphB1, autotransporter subtilisin-like protease; bvg, Bordetella virulence regulon; SHD, single human doseWhole-cell pertussis vaccines (WPVs) have been completely replaced by the co-purified acellular vaccines (APVs) in China. To date few laboratory studies were reported for co-purified APVs in terms of their antigenic composition and protective immune responses. To further understand the antigenic composition in co-purified APVs, in the present study 2-dimensional gel electrophoresis-based proteomic technology was used to analyze the composition of copurified APVs. The results showed that besides the main antigens pertussis toxin (PT) and filamentous hemagglutinin (FHA), co-purified APVs also contained pertactin (PRN), fimbriae (FIM) 2and3 and other minor protein antigens. Of the 9 proteins identified, 3 were differentially presented in products from manufacturer 1 and manufacturer 2. Compared with WPVs and purified APVs, co-purified APVs induced a mixed Th1/Th2 immune response with more toward to a Th1 response than the purified APVs in this study. These results hint that different immune mechanisms might be involved in protection induced by co-purified and purified APVs.

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“…The acellular pertussis antigens were pertussis toxin and filamentous haemagglutinin. 8 The minimum required potency for each of the components per 0.5-mL dose was 4 IU for whole cell pertussis or acellular pertussis, 30 IU for diphtheria, and 60 IU for tetanus toxoid. PG (Sinopharm Chemical Reagent Co, Ltd, Shanghai, China) was added to one batch of each of the vaccines prior to final pH adjustment.…”

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confidence: 99%

A freeze-stable formulation for DTwP and DTaP vaccines

Yang

Kristensen

Chen

2014

Human Vaccines & Immunotherapeutics

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Inadvertent vaccine freezing often occurs in the cold chain and may cause damage to freeze‑sensitive vaccines. Liquid vaccines that contain aluminum salt adjuvants are particularly vulnerable. Polyol cryoprotective excipients have been shown to prevent freeze damage to hepatitis B vaccine. In this study, we examined the freeze-protective effect of propylene glycol on diphtheria-tetanus-pertussis-whole-cell (DTwP) and acellular (DTaP) vaccines. Pilot lots of DTwP and DTaP formulated with 7.5% propylene glycol underwent 3 freeze-thaw treatments. The addition of propylene glycol had no impact on pH, particle size distribution, or potency of the vaccines prior to freeze-thaw treatment; the only change noted was an increase in osmolality. The potencies and the physical properties of the vaccines containing cryoprotectant were maintained after freeze-thawing and for 3 months in accelerated stability studies. The results from this study indicate that formulating vaccines with propylene glycol can protect diphtheria-tetanus-pertussis vaccines against freeze damages.

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Acellular pertussis vaccines in China

Cited by 30 publications

References 13 publications

Time series analysis of temporal trends in the pertussis incidence in Mainland China from 2005 to 2016

Time series analysis of temporal trends in the pertussis incidence in Mainland China from 2005 to 2016

Characterization of co-purified acellular pertussis vaccines

A freeze-stable formulation for DTwP and DTaP vaccines

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