Acellular Dermal Matrix as a Barrier for Guided Bone Regeneration of Dehiscence Defects Around Dental Implants

Momen-Heravi, Fatemeh; Peters, Scott M.; Garfinkle, Leonard; Kang, Philip

doi:10.1097/id.0000000000000796

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…Acellular tissue ECM scaffolds are natural biological biomaterials with effective removal of cell components which are supposed to have immunogenicity to the host, while retaining the naturally occurring three‐dimensional (3D) structure with tissue‐specific origins of ECM structural proteins (collagens and elastin), specialized proteins (fibrillin, fibronectin, and laminin), proteoglycans (glycosaminoglycan, heparin sulfate, and chondroitin sulfate), and growth factors which are hard to be created synthetically (Cheng, Solorio, & Alsberg, ; Gupta, Mishra, & Dhasmana, ). So far, acellular tissue materials used for GBR include human dermal (Borges et al, ; de Andrade et al, ; Momen‐Heravi, Peters, Garfinkle, & Kang, ), human amnion (Li et al, ), bovine pericardium (Bai et al, ), and porcine pericardium (Hwang, Kim, Kim, & Lee, ) out of which only acellular dermal are put into clinical use, and others are still in preclinical research stages. Although tissue‐derived ECM materials are commonly used to repair non‐homologous anatomic sites, materials derived from site‐specific homologous tissues have been suggested to be more helpful for constructive tissue remodeling as compared to nonsite‐specific tissue sources (Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of acellular sheep periostea for guided bone regeneration

et al. 2019

J Biomedical Materials Res

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The objective of this study was to fabricate an acellular sheep periosteum and explore its potential application in guided bone regeneration. Sheep periosteum was collected and decellularized by a modified decellularization protocol. The effectiveness of cell removal was proved by hematoxylin and eosin and 4 0 ,6-diamidino-2-phenylindole staining, DNA quantitative test, and agarose gel electrophoresis. After decellularization, its microstructure was found to become more porous while the integrality of collagen fibers remained undamaged, and the contents of collagen and glycosaminoglycan were not decreased significantly. Biomechanical analysis showed that the elastic modulus was significantly declined, while the yield stress was not affected, probably due to the collagen integrality. In vitro study of CCK-8 assay demonstrated that the acellular periosteum not only had no toxic effect to the MC3T3-E1 cells, but benefited the cell proliferation to some degree. In vivo experiment of guided bone regeneration was performed using a rabbit cranial model.Micro-CT and histological results revealed that the acellular periosteum not only effectively prevented the ingrowth of fibrous connective tissues, but also potentially facilitated bone regeneration. In conclusion, acellular sheep periostea, with wider sources, less costs, and more convenient fabrication process, would have great potential in the employment for guided bone regeneration. K E Y W O R D S acellular periosteum, animal experiment, barrier membrane, extracellular matrix, guided bone regeneration

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Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of acellular sheep periostea for guided bone regeneration

et al. 2019

J Biomedical Materials Res

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“…( Siddiqui et al, 2017 ; Jin et al, 2018 ). Momen-Heravi et al (2018) applied ADM to repair peri-implant bone-cracking and found that new bone was formed around the bone defect area with fine effect of bone reconstruction.…”

Section: Specific Types Of Barrier Membranesmentioning

confidence: 99%

Advances in Barrier Membranes for Guided Bone Regeneration Techniques

Yang

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. Among all the principal elements, barrier membrane is recognized as the key to the success of GBR. Ideal barrier membrane should have satisfactory biological and mechanical properties. According to their composition, barrier membranes can be divided into polymer membranes and non-polymer membranes. Polymer barrier membranes have become a research hotspot not only because they can control the physical and chemical characteristics of the membranes by regulating the synthesis conditions but also because their prices are relatively low. Still now the bone augment effect of barrier membrane used in clinical practice is more dependent on the body’s own growth potential and the osteogenic effect is difficult to predict. Therefore, scholars have carried out many researches to explore new barrier membranes in order to improve the success rate of bone enhancement. The aim of this study is to collect and compare recent studies on optimizing barrier membranes. The characteristics and research progress of different types of barrier membranes were also discussed in detail.

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“…During this process, the alveolar ridge undergoes relevant changes, both in height and in thickness, which influence the possibility of installing the implants. Thus, the optimized processes of implantology and biomaterials allow the installation of implants in areas of thin bone thickness, width and height, with simpler surgeries and greater success rate and patient comfort [25].…”

Section: Molecular and Cellular Processesmentioning

confidence: 99%

Bone regeneration processes with the use of biomaterials and molecular and cellular constituents for dental implants

Carvalho¹,

Kassis²

2022

MedNEXT

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Introduction: When a dental element is lost in the posterior region of the maxilla, there is a natural reabsorption of the alveolar process and, at the same time, pneumatization of the maxillary sinus will occur. For this reason, the maxillary sinus floor elevation procedure should be performed, or short implants when possible. Often the focus is on the type of biomaterial to be used and the success and predictability of our results does not depend only on the biomaterial. It is also necessary to consider the type of defect to be treated, its morphology. The characteristics of the biomaterials to be used must be considered, as well as the characteristics of the bed and the bone defect for treatment. Objective: It was to carry out a concise systematic review of bone regeneration processes using biomaterials and the main molecular and cellular constituents for subsequent dental implantation. Methods: The present study followed by a systematic review model (PRISMA). The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The Cochrane Instrument was used to assess the risk of bias of the included studies. Results and Conclusion: 152 articles involving implantology and biomaterials were found. A total of 64 articles were fully evaluated and 28 were included in the present study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 5 studies with high risk of bias (studies with small sample size) and 3 studies with uncertain risk (studies with results without statistical significance). The search for a solution for large bone defects directed studies to tissue regeneration therapy or bone regeneration. These studies can promote the use of fillers and epithelial barriers that help in the treatment as an adjuvant to bone graft techniques, favoring greater predictability in alveolar and peri-implant reconstructions and with a good prognosis. The main filler biomaterials can be fibrin-rich plasma, Bio-Oss®. However, it is necessary to understand the chemical, physical and biological processes of both the biological material and the biological niche of the host. Crossing compatible information between microenvironments allows cell recognition and signaling cascades for neovascularization and regeneration and bone filling for successful posterior dental implant.

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Acellular Dermal Matrix as a Barrier for Guided Bone Regeneration of Dehiscence Defects Around Dental Implants

Cited by 17 publications

References 17 publications

Preparation and evaluation of acellular sheep periostea for guided bone regeneration

Preparation and evaluation of acellular sheep periostea for guided bone regeneration

Advances in Barrier Membranes for Guided Bone Regeneration Techniques

Bone regeneration processes with the use of biomaterials and molecular and cellular constituents for dental implants

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