To synthesize the available evidence regarding lip repositioning surgery (LRS) and quantify the short‐ and long‐term reduction in excessive gingival display (EGD) with the procedure. Additionally, evaluate the effect of myotomy on the results. Seven electronic databases were searched up to May 2020 by two independent reviewers. Studies evaluating the exclusive use of LRS to treat EGD were included. After risk of bias assessment, the data were quantitatively evaluated with random‐effects meta‐analysis. The initial database search yielded 368 studies, of which 16 were selected for full‐text review. Finally, eight studies were included. The random effects model exhibited an EGD reduction of 2.87 mm (95% CI: 1.91–3.82) after 3 months of LRS. These results decreased after 6 months (2.71 mm; 95% CI: 1.95–3.47) and 12 months (2.10 mm; 95% CI: 1.48–2.72). Meta‐analysis comparing the performance of myotomy showed greater EGD reduction at 6 months than without myotomy (P < 0.02). LRS is an effective approach for treating EGD, and it has satisfactory results up to 6 months. After this period, the effectiveness appears to progressively decrease over time indicating substantial relapse at 12 months. Myotomy seems a suitable alternative to increase the stability of LRS. Lip repositioning surgery is an effective procedure to improve smile esthetics in the short‐term (up to 6 months). After this period, the efficacy of LRS seems to decrease progressively, and an approximately 25% relapse may be expected after 12 months. Clinicians should combine the procedure with other approaches, such as plastic periodontal surgeries, restorative procedures, or botulin toxin injections for more predictable and stable outcomes.

The present work studied the adverse effects of maternal exposure of rats to alcohol during lactation, on the development of their offspring. Histometric evaluation by karyometry and of the alveolar bone at the level of the first upper molar of the sucking was perfomed. Two groups of animals, one coming from mothers exposed to drinking water containing 20% ethanol during the total lactation period and the other of controls coming from mothers receiving only alcohol-free drinking water during this period. On the 21 first day of lactation the young of each group were aleatorily selected and following anesthesia, their heads severed; after histological treatment, serial 6 µ m sections on the frontal plane at the molar level, stained with hematoxilin and eosin, were obtained. The experimental results produced, suggest that sucking from ethanol-treated mothers, show retarded post-natal growth, their alveolar bones presenting scarce, little calcified trabeculae, and a more abundant bone marrow compared to controls.

Scaffolds of chitosan and collagen can offer a biological niche for the growth of adipose derived stem cells (ADSC). The objective of this work was to characterize the physico-chemical properties of the scaffolds and the ADSC, as well as their interactions to direct influences of the scaffolds on the behavior of ADSC. The methodology included an enzymatic treatment of fat obtained by liposuction by collagenase, ASDC immunophenotyping, cell growth kinetics, biocompatibility studies of the scaffolds analyzed by the activity of alkaline phosphatase (AP), nitric oxide (NO) determination by the Griess-Saltzman reaction, and images of both optical and scanning electron microscopy of the matrices. The extent of the crosslinking of genipin and glutaraldehyde was evaluated by ninhydrin assays, solubility tests and degradation of the matrices. The results showed that the matrices are biocompatible, exhibit physical and chemical properties needed to house cells in vivo and are strong stimulators of signaling proteins (AP) and other molecules (NO) which are important in tissue healing. Therefore, the matrices provide a biological niche for ADSC adhesion, proliferation and cells activities.

Introduction: Bone augmentation techniques have been increasingly indicated to recreate adequate bone height and volume for dental implant sites. Maxillary sinus augmentation can be performed with or without graft biomaterials. In this sense, fibrin-rich plasma (PRF) stands out, which is a three-dimensional (3-D) autogenous biomaterial. Objective: It was carried out a systematic review of the literature on the main considerations and clinical findings of bone grafting and fibrin-rich plasma in oral and maxillofacial surgery. Methods: The present study followed a systematic review model, following the rules of systematic review – PRISMA. The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: The total of 256 articles were found. A total of 64 articles were fully evaluated and 28 were included in this study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 134 studies that were excluded with a high risk of bias (studies with small sample size). Also, 38 studies were excluded because they did not meet the GRADE. The application of autologous platelet-rich plasma provides benefits in promoting soft tissue healing and bone regeneration in different surgical procedures, as well as being favorable for bone formation processes for dental implants, especially when combined with xenografts. In addition, it is an autologous, low-cost biomaterial that does not require the administration of additives. However, further studies with larger sample sizes and longer follow-up times are needed to provide more substantial evidence of the efficacy of platelet-rich plasma in promoting soft and hard tissue healing.

Introduction: In the context of bone regeneration, bone defects still represent a major challenge in oral and maxillofacial clinical and surgical treatment. The biomimetic design of biomaterials by simulating the natural structure and composition of bone tissue has gradually become a point of research interest due to its advantages of simplicity and efficiency. Objective: It was to carry out a systematic review on cellular and molecular processes, as well as to present the main clinical approaches of bone regeneration for dental implants. Methods: The present study followed a systematic review model, following the rules of systematic review – PRISMA. The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 142 articles were found. A total of 84 articles were fully evaluated and 33 were included in this study. Literary findings have shown that the lack of bone in the alveolar ridges has been a major problem in functional aesthetic recovery in patients who have suffered dentoalveolar trauma. The osteoinduction process is influenced by several factors, requiring the presence of inducers, which include β-glycerolphosphate, ascorbic acid, and dexamethasone. Mesenchymal stem cells acquire the morphology and components of osteoblastic membranes and begin to express alkaline phosphatase to deposit extracellular matrix rich in calcium and certain proteins, such as osteopontin and osteocalcin. The Bio Oss® (Geistlich) biomaterial, because it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators, can act in the regeneration of bone tissue. Application of FRP and implant placement provides stable clinical results for severely atrophic maxilla 2-4 mm. Bovine xenograft alone and in combination with liquid FRP are both successful in achieving bone augmentation around implants and produce a small change in marginal bone level and a high implant survival rate after loading. Conclusion: Through the results of the present study, it was evidenced that the success of the dental implant is directly related to successful osseointegration.

Introduction: When a dental element is lost in the posterior region of the maxilla, there is a natural reabsorption of the alveolar process and, at the same time, pneumatization of the maxillary sinus will occur. For this reason, the maxillary sinus floor elevation procedure should be performed, or short implants when possible. Often the focus is on the type of biomaterial to be used and the success and predictability of our results does not depend only on the biomaterial. It is also necessary to consider the type of defect to be treated, its morphology. The characteristics of the biomaterials to be used must be considered, as well as the characteristics of the bed and the bone defect for treatment. Objective: It was to carry out a concise systematic review of bone regeneration processes using biomaterials and the main molecular and cellular constituents for subsequent dental implantation. Methods: The present study followed by a systematic review model (PRISMA). The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The Cochrane Instrument was used to assess the risk of bias of the included studies. Results and Conclusion: 152 articles involving implantology and biomaterials were found. A total of 64 articles were fully evaluated and 28 were included in the present study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 5 studies with high risk of bias (studies with small sample size) and 3 studies with uncertain risk (studies with results without statistical significance). The search for a solution for large bone defects directed studies to tissue regeneration therapy or bone regeneration. These studies can promote the use of fillers and epithelial barriers that help in the treatment as an adjuvant to bone graft techniques, favoring greater predictability in alveolar and peri-implant reconstructions and with a good prognosis. The main filler biomaterials can be fibrin-rich plasma, Bio-Oss®. However, it is necessary to understand the chemical, physical and biological processes of both the biological material and the biological niche of the host. Crossing compatible information between microenvironments allows cell recognition and signaling cascades for neovascularization and regeneration and bone filling for successful posterior dental implant.

Introduction: In the scenario of maxillary sinus surgery for the later practice of implantology, several surgical techniques can be used to reconstruct the atrophic alveolar ridge, isolated techniques or associated with autogenous, allogeneic, xenogenous, and alloplastic biomaterials. The autogenous bone graft is the only one capable of presenting three important biological properties (osteogenesis, osteoinduction, and osteoconduction) guaranteeing a self-regenerative potential. Platelet concentrates have been proposed as regenerative materials in tissue regeneration procedures. Among the platelet concentrates proposed in the literature, there is FRP that act as autogenous platelet aggregates with osteoinductive properties. As an example of xenografts, Bio-Oss® stands out, being a bovine bone biomaterial. The excellent osteoconductive properties of Bio-Oss® lead to predictable and efficient bone regeneration, becoming an integral part of bone structure and volume. Objective: To carry out a brief systematic review of the main considerations for the use of fibrin-rich plasma and Bio Oss® in bone regeneration for implant dentistry. Methods: The survey was conducted from May 2021 to July 2021 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar, following the rules of Systematic Review-PRISMA. Study quality was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: The lack of bone in the alveolar crests has been a major problem in functional aesthetic recovery in patients who have suffered dentoalveolar trauma, traumatic tooth extractions, congenital tooth loss, maxillary and mandibular pathologies, in addition to infections due to the emotional and possibility of deformity. In this context, implant dentistry stands out as a modern method of oral rehabilitation for totally or partially edentulous patients. For this method to develop properly, bone integration of the implant into the recipient bone tissue must occur. It was documented that the combination of biomaterial and FRP significantly improved bone regeneration in the peri-implant area. Placing the implant with the simultaneous use of the FRP creates a good relationship between hard tissue and soft tissue. FRP is used as an adjuvant to Bio-Oss® particles for bone augmentation in the maxillary sinus. Conclusion: Based on literary findings, it was shown that FRP is favorable for bone formation processes for dental implants, especially when combined with Bio-Oss®.

Epidermolysis bullosa occurs in all races worldwide and not differ on incidence between the genders. It is a very rare disease and its occurrence in the population is not known precisely, but it is estimated that the prevalence of dystrophic form is between one case in every 20,000 to 130,000 people and the way acquired a case for 1.3 million people. According to epidemiological data from the United States, there are 50 cases of epidermolysis bullosa 1,000,000 live births. The present study is an attempt to rehabilitate the patient's dentition in question through two hybrid dentures supported on the teeth using a non-invasive treatment and in an efficient manner. Case Report, CF patient, 42 years old, male, white, attended the clinic specialized in prosthodontics University Center North Paulista (UNORP) due to their need for oral rehabilitation. In discussion, by treating able to improve masticatory function, besides the same show already be accustomed to the use of hearing aids without appearance of lesions or blisters and very satisfied with the aesthetic result, increasing their self-esteem. In conclusion, the rehabilitation by means of two hybrid supported denture on teeth has been successfully performed via a non-invasive and efficient treatment.