Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography

Kholodnykh, A I; Petrova, Irina Y.; Motamedi, Massoud; Esenaliev, Rinat O.

doi:10.1109/jstqe.2003.814194

Cited by 40 publications

(30 citation statements)

References 24 publications

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“…The accuracy with which the attenuation coefficient could be determined, regardless of the focus position, is approximately 0.8 mm -1 . The precision of the individual measurements (i.e., defined as 95% confidence intervals in this paper) is much higher and in general less then 10%, comparable to for example [11] and [17].…”

Section: Discussionmentioning

confidence: 70%

“…In clinically used probes and catheters, the optical components of the sample arm are fixed. Therefore, for quantitative extraction of µ t , the confocal properties of the OCT system have to be taken into account, i.e., the change of the OCT signal with increasing distance between the probed location in the tissue and location of the focus [10,11]. We have recently derived a general expression for the confocal axial point spread function (PSF) for single mode fiber (SMF) based OCT systems [12].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

et al. 2004

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Abstract. From calibrated, weakly scattering tissue phantoms (2-6 mm -1 ), we extract the attenuation coefficient with an accuracy of 0.8 mm -1 from OCT data in the clinically relevant 'fixed focus' geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

et al. 2004

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“…An OCT system using a low-power source such as a laser or a LED in the visible and near-infrared range can typically image at a depth of 1mm in the skin [7]. Furthermore, the OCT signal can be used to extract the optical attenuation coefficient of the tissue, which quantifies the scattering and absorption phenomena and can give valuable information about the state of the tissue [8,9].…”

Section: Vol 8 No 3 | 1 Mar 2017 | Biomedical Optics Express 1577mentioning

confidence: 99%

Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries

Santos

Latrive

Castro

et al. 2017

Biomed. Opt. Express

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Thousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were noninvasively characterized by OCT images and biopsied for further histopathology analysis, SHG imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as efficient as the classical treatment for promoting the healing process. The study concludes to the validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of minimizing operatory trauma.

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“…The Rayleigh model proves to be a good model for the firstorder statistics of OCT images as well [13], [14], even though under certain conditions a Gaussian model holds [15]. An analytical model that describes the performance of OCT signals in both single and multiple scattering regimes is presented in [16] and [17] and the influence of multiple scattering on the measurement of the total attenuation coefficient is described in [18] and [19]. In [20], the correlation between OCT speckle and the statistical and optical properties of the sample tissue are discussed.…”

Section: Speckle Noise In Octmentioning

confidence: 99%

Multiresolution Denoising for Optical Coherence Tomography: A Review and Evaluation

Pižurica¹,

Jovanov²,

Huysmans³

et al. 2008

CMIR

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Abstract:Recently emerging non-invasive imaging modality -optical coherence tomography (OCT) -is becoming an increasingly important diagnostic tool in various medical applications. One of its main limitations is the presence of speckle noise which obscures small and low-intensity features. The use of multiresolution techniques has been recently reported by several authors with promising results. These approaches take into account the signal and noise properties in different ways. Approaches that take into account the global orientation properties of OCT images apply accordingly different level of smoothing in different orientation subbands. Other approaches take into account local signal and noise covariance's.So far it was unclear how these different approaches compare to each other and to the best available single-resolution despeckling techniques. The clinical relevance of the denoising results also remains to be determined. In this paper we review systematically recent multiresolution OCT speckle filters and we report the results of a comparative experimental study.We use 15 different OCT images extracted from five different three-dimensional volumes, and we also generate a software phantom with real OCT noise. These test images are processed with different filters and the results are evaluated both visually and in terms of different performance measures. The results indicate significant differences in the performance of the analyzed methods. Wavelet techniques perform much better than the single resolution ones and some of the wavelet methods improve remarkably the quality of OCT images.

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Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography

Cited by 40 publications

References 24 publications

Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries

Multiresolution Denoising for Optical Coherence Tomography: A Review and Evaluation

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