Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans　– A Validation Study –

Nishimiya, Kensuke; Matsumoto, Yasuharu; Uzuka, Hironori; Oyama, Kazuma; Tanaka, Atsushi; Taruya, Akira; Ogata, Tsuyoshi; Hirano, Minoru; Shindo, Tomohiko; Hanawa, Kenichiro; Hasebe, Yasushi; Hao, Kun; Tsuburaya, Ryuji; Takahashi, Jun; Miyata, Satoshi; Ito, Kei; Shimokawa, Hiroaki

doi:10.1253/circj.cj-15-0078

Cited by 27 publications

(13 citation statements)

References 31 publications

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“…We have recently demonstrated that at 9-12 months after stent implantation, adventitial VV formation on the optical frequency domain imaging system 37 is significantly enhanced at the stent edges of everolimus-eluting stents with durable polymers as compared with BES in humans in vivo. 38 Finally, although we were able to demonstrate the association of the abnormalities in the adventitia (eg, inflammation, VV angiogenesis and Rhokinase activation), the detailed time-course and interactions among them remain to be examined in future studies.…”

Section: Discussionmentioning

confidence: 82%

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Nishimiya

Matsumoto

Shindo

et al. 2015

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jpIn order to reduce the adverse effects of the first-generation DES, many efforts have been made, including the development of a newer biocompatible DES. 9 Biolimus-A9 eluting stent (BES) is one of the new-generation DES with unique characteristics, such as biodegradable polymers that are absorbed into the arterial wall approximately 6 months after stent implantation. 9-11 Although BES has recently been shown to preserve ex-vivo coronary vasomotion as compared with SES in the short-term observations in pigs 12 and humans, 7 its mechanism remains largely unknown.We have previously demonstrated that Rho-kinase activation is a central molecular mechanism of coronary spasm in he widespread utilization of drug-eluting stents (DES) has remarkably reduced the risk of re-stenosis and of repeated revascularization. 1 However, the first-generation DES with durable polymers, such as sirolimus-eluting stents (SES), have no beneficial prognostic effects as compared with bare metal stents 2 or even cause unfavorable effects, such as stent thrombosis 3,4 and coronary hyperconstricting responses, 5-8 not only to acetylcholine, 5 but also to exercise 6 and atrial pacing. Background: The importance of adventitial inflammation has been implicated for the pathogenesis of coronary artery disease. However, the roles of adventitial changes in drug-eluting stent (DES)-induced coronary hyperconstriction remain largely unknown. In the present study, this issue in pigs in vivo with a special reference to adventitial vasa vasorum (VV) formation and Rho-kinase activation, a central mechanism of coronary vasospasm, was examined.

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Section: Discussionmentioning

confidence: 82%

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Nishimiya

Matsumoto

Shindo

et al. 2015

Circ J

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“…Optical coherence tomography (OCT) is a high-resolution (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) mm), near infrared light-based, intravascular imaging technique. The spatial resolution of OCT is sharp enough to detect intraplaque and adventitial vasa vasorums.…”

Section: Vasa Vasorum Imagingmentioning

confidence: 99%

Gray-scale intravascular ultrasound sheds light on the importance of vasa vasorum in unstable coronary plaque

Kubo

2017

Journal of Cardiology

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“…After initial validation study (66), Taruya has recently demonstrated that vasa vasorum volume is positively correlated with plaque volume, and that intra-plaque neovascularization is associated with features of plaque vulnerability, especially noting the coral tree pattern is more frequent in ruptured plaques.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Pathan

Negishi

2016

Cardiovasc. Diagn. Ther.

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Over the last two decades, several invasive and non-invasive coronary atherosclerosis imaging modalities have emerged as predictors of cardiovascular outcomes in at-risk population. These modalities have demonstrated independent or incremental prognostic information over existing/standard risk stratification schemes, such as the Framingham risk score (FRS), by identifying characteristics of coronary artery diseases (CADs). In this review, we begin with discussing the importance of pre-test probability and quality of outcome measure, followed by specific findings of each modality in relation to prognosis. We focused on both short and long term prognostic aspects of coronary computed tomography (CT) (including coronary calcium score and coronary angiography) and magnetic resonance imaging as non-invasive tools, as well as invasive modalities including intravascular ultrasound (IVUS), optical coherence tomography (OCT), near infrared spectroscopy and Angioscopy.

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Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans　– A Validation Study –

Cited by 27 publications

References 31 publications

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Gray-scale intravascular ultrasound sheds light on the importance of vasa vasorum in unstable coronary plaque

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

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Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans – A Validation Study –

Cited by 27 publications

References 31 publications

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo

Gray-scale intravascular ultrasound sheds light on the importance of vasa vasorum in unstable coronary plaque

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

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Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans　– A Validation Study –