Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Pathan, Faraz; Negishi, Kazuaki

doi:10.21037/cdt.2015.12.08

Cited by 8 publications

(6 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to conventional angiography, CTCA has been reported to have higher accuracy in identifying calcified and non-calcified plaques, and coronary positive remodeling [78,79]. While more than 95% of arterial stenosis documented with angiography are confirmed by CTCA, only one-third of those detected with CTCA are identified by angiography.…”

Section: Computed Tomography Coronary Angiography (Ctca)mentioning

confidence: 99%

“…IVUS and OCT allow direct cross-sectional visualization of the coronary wall and are now considered the gold standard for in vivo imaging of coronary calcification [79,100,103]. IVUS imaging is based on ultrasound reflection by coronary calcification and is more sensitive and specific than angiography ( Figure 5).…”

Section: Intravascular Ultrasound (Ivus) and Optical Coherence Tomogrmentioning

confidence: 99%

“…OCT uses a light source in the near-infrared range and measures the time delay of optical echoes reflected by the arterial wall, providing high-resolution cross sectional images of the plaque structure [79,110]. (Figure 6).…”

Section: Intravascular Ultrasound (Ivus) and Optical Coherence Tomogrmentioning

confidence: 99%

See 2 more Smart Citations

Coronary Atherosclerosis Imaging

et al. 2020

View full text Add to dashboard Cite

Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention. Imaging techniques provide direct assessment of coronary atherosclerotic burden and pathological characteristics of atherosclerotic lesions which may predict the progression of disease. Atherosclerosis imaging has been traditionally based on the evaluation of coronary luminal narrowing and stenosis. However, the degree of arterial obstruction is a poor predictor of subsequent acute events. More recent techniques focus on the high-resolution visualization of the arterial wall and the coronary plaques. Most acute coronary events are triggered by plaque rupture or erosion. Hence, atherosclerotic plaque imaging has generally focused on the detection of vulnerable plaque prone to rupture. However, atherosclerosis is a dynamic process and the plaque morphology and composition may change over time. Most vulnerable plaques undergo progressive transformation from high-risk to more stable and heavily calcified lesions, while others undergo subclinical rupture and healing. Although extensive plaque calcification is often associated with stable atherosclerosis, the extent of coronary artery calcification strongly correlates with the degree of atherosclerosis and with the rate of future cardiac events. Inflammation has a central role in atherogenesis, from plaque formation to rupture, hence in the development of acute coronary events. Morphologic plaque assessment, both invasive and non-invasive, gives limited information as to the current activity of the atherosclerotic disease. The addition of nuclear imaging, based on radioactive tracers targeted to the inflammatory components of the plaques, provides a highly sensitive assessment of coronary disease activity, thus distinguishing those patients who have stable disease from those with active plaque inflammation.

show abstract

Section: Computed Tomography Coronary Angiography (Ctca)mentioning

confidence: 99%

Section: Intravascular Ultrasound (Ivus) and Optical Coherence Tomogrmentioning

confidence: 99%

See 1 more Smart Citation

Coronary Atherosclerosis Imaging

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The chronic inﬂammatory process may predispose to atherosclerosis. Atherosclerosis is the main condition predisposing to the onset of cardiovascular (CV) events [2]. Atherothrombotic complications are an important cause of mortality and morbidity in many inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

2019

View full text Add to dashboard Cite

Background: Ulcerative colitis (UC) is characterized by chronic relapsing-remitting inﬂammation of the gastrointestinal tract. The chronic inﬂammatory process may predispose to atherosclerosis. The aim of the study was to assess the carotid intima-media thickness (CIMT) and its relation to subclinical atherosclerosis and to follow up cardiovascular complications in patients with UC. Methods: 83 patients with proven UC in remission were enrolled in the study. 42 age- and sex-matched healthy controls were taken. Patients with known risk factors for atherosclerosis were excluded from the study. Baseline blood investigations along with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fasting lipid profile were done. CIMT was measured using B-mode Doppler imaging study. Results: The mean age of the UC patients was 37.06 ± 14.87 years. Left-sided colitis (45.8%) was the commonest type of presentation according to the extent of the disease. Mean CIMT (0.55 ± 0.17) was significantly higher in UC patients when compared to mean CIMT (0.46 ± 0.13) in the control group (p = 0.002). In Pearson correlation analysis, age, ESR, and CRP were positive and significantly correlated with CIMT. Multiple linear regression analysis (R² = 0.18, p = 0.0026) revealed that age and CRP were significant independent predictors of mean CIMT. On following up for 6 months, 4 patients with UC had complications in the form of venous thrombosis. Conclusion: CIMT is a simple, noninvasive, reliable and objective auxiliary vascular parameter of structural alteration in UC patients.

show abstract

“…Atherosclerosis is the main condition predisposing to the onset of cardiovascular (CV) events (1). There are some well-recognized risk factors for atherosclerosis development, including hypertension, hypercholesterolemia, diabetes mellitus, current smoking, and obesity (2).…”

Section: Introductionmentioning

confidence: 99%

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

Bruzzese

Palermo

Lorenzetti

et al. 2017

Annals of Translational Medicine

View full text Add to dashboard Cite

Background: An independent role of chronic inflammation in the atherosclerotic process in patients with inflammatory bowel diseases (IBD) has been suggested, but data are still contentious. We assessed preclinical atherosclerosis in the IBD patients without traditional risk factors. Methods:In this case-control study we assessed the early atherosclerotic alterations by carotid artery intima-media thickness (CIMT) measurement in IBD patients and matched controls. The normal CIMT values were ≤0.9 mm; moderate thickness when >0.9 and ≤1.2 mm, and pre-clinical atherosclerosis when >1.2 mm. We selected a homogeneous group of IBD patients, all in ongoing biologic therapy, without any traditional risk factor for atherosclerosis as well as controls. Conclusions: This case-control study found that the atherosclerotic process is not more apparent in IBD patients without traditional risk factors.

show abstract

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Cited by 8 publications

References 109 publications

Coronary Atherosclerosis Imaging

Coronary Atherosclerosis Imaging

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

Contact Info

Product

Resources

About