Accuracy of Death Certification in an Autopsied Population With Specific Attention to Malignant Neoplasms and Vascular Diseases

Engel, Linda W.; Strauchen, James A.; Chiazze, Leonard; Heid, Marian F.

doi:10.1093/oxfordjournals.aje.a112879

Cited by 161 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conversely, it has been demonstrated that population-based studies that rely on cancer-specific mortality suffer from misclassification bias because of inaccuracies of the causes of death documented on death certificates. [29][30][31] In summary, our population-based study results support previous reports that mode and depth of invasion are critical prognostic factors among patients with tongue cancer. It is worth pointing out that patients who had unknown DI (presumably representing a combination of patients with poor and good survival) had a statistically significant 9-fold increase in mortality compared with patients whose DI was documented as 3 mm.…”

Section: Discussionsupporting

confidence: 89%

Invasion characteristics of oral tongue cancer

Goodman¹,

Liu²,

Ward³

et al. 2009

Cancer

View full text Add to dashboard Cite

Background This study explored the blood transfusion patterns, SCD complications, utilization of iron chelation therapies (ICT), healthcare resource use, and costs in pediatric, transitioning (18 years old) and adult patients with SCD. Procedure Data from Florida (1998–2009), New Jersey (1996–2009), Missouri (1997–2010), Kansas (2001–2009), and Iowa (1998–2010) state Medicaid were used. Patients with ≥2 SCD diagnoses and ≥1 transfusion event were included. Rates of transfusion events, SCD complications, and proportion of eligible patients receiving ICT were calculated. ICT eligibility was defined as receiving ≥10 transfusions over lifetime. SCD complications included pain, pulmonary event, infection event, renal, cardiovascular, stroke, leg ulcers, and avascular necrosis. Regressions were used to assess risk factors for transfusion and identify the main drivers of costs. Results The sample included 3,208 patients. The transfusion rate increased from 1‐year‐old to a peak at 16 years old, then dropped until age 26 and remained stable thereafter. In contrast the frequency of diagnoses for SCD complications increased markedly after age 16. Post‐transition patients (≥18 years old) were significantly associated with fewer transfusions (odds ratio: 0.80, P = 0.002). Among eligible patients for ICT, there was no statistically significant difference in total cost between the ICT and no ICT groups (adjusted cost difference, $136, P = 0.114). Conclusions Patients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer 2013; 60: 828–835. © 2013 Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 89%

Invasion characteristics of oral tongue cancer

Goodman¹,

Liu²,

Ward³

et al. 2009

Cancer

View full text Add to dashboard Cite

show abstract

“…Literature has reported that the accuracy of coding varied with the cause of death, especially when the deceased had two conditions concurrently and both contributed to death. 30,31 Three approaches were used to minimize the potential misclassification in the study. First, a relatively wide range of categories of cause of death was chosen to avoid potential serious misclassification of cause-specific mortality.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Pattern of the Acute Mortality Effects of Air Pollution

Qian

Lin

Stewart³

et al. 2010

Journal of the Air & Waste Management Association

View full text Add to dashboard Cite

Evidence of seasonal variation of acute mortality effects of air pollution is inconsistent. The seasonal patterns of associations between daily mortality and daily mean concentrations of particulate matter 10 m or less in aerodynamic diameter (PM 10 ), sulfur dioxide (SO 2 ), and nitrogen dioxide (NO 2 ) were examined using 4 yr of data (2001)(2002)(2003)(2004) in Wuhan, China. Four distinct seasons occur in Wuhan, where approximately 4.5 million residents live in the city core area of 201 km 2 . Air pollution levels are higher and pollution ranges are wider in Wuhan than in most cities. Quasi-likelihood estimation within the context of the generalized additive models (natural spline [NS] models in R) was used to model the natural logarithm of the expected daily death counts as a function of the predictor variables. The estimates of the interaction between seasons and pollution were obtained from the main effects and pollutant season interaction models. It was found that the interactions between three pollutants and cause-specific mortality were statistically significant (P Ͻ 0.05). The strongest effects occurred consistently in winter for all-natural, cardiovascular, stroke, and respiratory mortality. Every 10-g/m 3 increase in PM 10 daily concentration at lag 0 -1 days was associated with an increase in all-natural mortality of 0.69% (95% confidence interval [CI]: 0.44 -0.94%) for winter, 0.34% (95% CI: 0.00 -0.69%) for spring, 0.45% (95% CI: Ϫ0.13 to IMPLICATIONS This study suggests that season significantly modified the mortality effect of pollutants. The highest pollution levels of PM 10 , SO 2 , and NO 2 occurred in winter, and so did the strongest effects of PM 10 , SO 2 , and NO 2 on all daily causespecific mortality. These results may have implications for local environmental protection agencies and public health agencies in efforts to limit pollution emissions in winter and to reduce the wintertime exposure to pollutants.

show abstract

“…The interpretation of epidemiological research based on death certification data has been questioned by some [23], mainly in terms of the accuracy of the information. A recent autopsy study showed that the underlying cause of death, assigned by the pathologist, was mentioned on the death certificates in 72% of cases [24]. Multiple-cause analysis, where all conditions mentioned on.…”

Section: Discussionmentioning

confidence: 99%

Diabetes mortality: New light on an underestimated public health problem

Fuller

Elford²,

Goldblatt³

et al. 1983

Diabetologia

163

View full text Add to dashboard Cite

Summary. Mortality from diabetes is underestimated four-tofivefold by methods of analysis of death certification data which use only underlying cause of death. This problem is partially overcome by coding all conditions mentioned on death certificates. For a sample of deaths in England and Wales over the years 1972-1977, the observed proportion of certificates with specific underlying causes of death for certificates mentioning diabetes was compared with the expected proportion for all certificates. These observed/expected ratios were significantly increased in each sex for circulatory diseases and were significantly reduced for neoplasms. For 'nephritis' they were also increased, especially below 45 years of age. These results were confirmed by an analysis of underlying cause of death in a cohort of nearly 6,000 members of the British Diabetic Association. Of the 2,134 deaths in this coholt, diabetes was not mentioned on 33% of the death certificates. For the period 1972-1977, death rates for circulatory diseases associated with diabetes increased by 6% for males but remained constant for females.

show abstract

Accuracy of Death Certification in an Autopsied Population With Specific Attention to Malignant Neoplasms and Vascular Diseases

Cited by 161 publications

References 0 publications

Invasion characteristics of oral tongue cancer

Invasion characteristics of oral tongue cancer

Seasonal Pattern of the Acute Mortality Effects of Air Pollution

Diabetes mortality: New light on an underestimated public health problem

Contact Info

Product

Resources

About