Accuracy and precision of hemoglobin point‐of‐care testing during major pediatric surgery

Spielmann, Nelly; Mauch, Jacqueline; Madjdpour, Caveh; Schmugge, Markus; Weiß, Markus; Haas, Thorsten

doi:10.1111/j.1751-553x.2011.01363.x

Cited by 26 publications

(20 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…42 reported a different analyzer (IPOC-1) having a lower mean Hb concentration (4.9 g/L). Spielmann et al, 138 Broderick et al., 43 and Zatloukal et al 106 analyzed venous blood by clinical laboratory blood gas analyzers compared with the reference in five comparisons. Broderick et al .…”

Section: Resultsmentioning

confidence: 99%

“…Spielmann et al found two different clinical blood gas analyzers (CBGA-1 and CBGA-2) to have a higher mean Hb concentration (5.8–8.0 g/L) and one analyzer (CBGA-3) to have a lower mean Hb concentration (0.5 g/L) compared with the reference. 138 When applying the mean concentration difference threshold of ±7% for the studies comparing the other portable photometric invasive POC analyzers or clinical laboratory blood gas analyzers with the reference, 11 studies including 17 comparisons 18,31,43,102,106,110,113,120,121,138 met the allowable degree of variation with one study exceeding the ±7% bias 42 (Fig. 4).…”

Section: Resultsmentioning

confidence: 99%

“…110 Ardin et al 42 reported a higher mean Hb concentration (1.2 g/L) using one invasive POC analyzer (IPOC-2) 42,102,110 and Ardin et al 42 reported a different analyzer (IPOC-1) having a lower mean Hb concentration (4.9 g/L). Spielmann et al, 138 Broderick et al, 43 and Zatloukal et al 106 analyzed venous blood by clinical laboratory blood gas analyzers compared with the reference in five comparisons. Broderick et al 43 found a lower mean Hb concentration (1.5 g/L) and Zatloukal et al 106 found a higher mean Hb concentration (1.0 g/L).…”

Section: Figure 4 Differences In Mean Hb Of the Other Invasive Pointmentioning

confidence: 99%

See 2 more Smart Citations

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Whitehead

Mei

Mapango

et al. 2019

Annals of the New York Academy of Sciences

118

100

View full text Add to dashboard Cite

This paper describes and compares methods and analyzers used to measure hemoglobin (Hb) in clinical laboratories and field settings. We conducted a literature review for methods used to measure Hb in clinical laboratories and field settings. We described methods to measure Hb and factors influencing results. Automated hematology analyzer (AHA) was reference for all Hb comparisons using evaluation criteria of ±7% set by College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA). Capillary fingerprick blood usually produces higher Hb concentrations compared with venous blood. Individual drops produced lower concentrations than pooled capillary blood. Compared with the AHA: (1) overall cyanmethemoglobin (1.0–8.0 g/L), WHO Colour Scale (0.5–10.0 g/L), paper-based devices (5.0–7.0 g/L), HemoCue® Hb-201 (1.0–16.0 g/L) and Hb-301 (0.5–6.0 g/L), and Masimo Pronto® (0.3–14.0 g/L) overestimated concentrations; (2) Masimo Radical® −7 both under- and overestimated concentrations (0.3–104.0 g/L); and (3) other methods underestimated concentrations (2.0–16.0 g/L). Most mean concentration comparisons varied less than ±7% of the reference. Hb measurements are influenced by several analytical factors. With few exceptions, mean concentration bias was within ±7%, suggesting acceptable performance. Appropriate, high-quality methods in all settings are necessary to ensure the accuracy of Hb measurements.This paper describes and compares methods and analyzers used to measure hemoglobin (Hb) in clinical laboratories and field settings. With few exceptions, mean concentration bias was within ±7%, suggesting acceptable performance. Appropriate, high-quality methods in all settings are necessary to ensure the accuracy of Hb measurements.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Figure 4 Differences In Mean Hb Of the Other Invasive Pointmentioning

confidence: 99%

See 1 more Smart Citation

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Whitehead

Mei

Mapango

et al. 2019

Annals of the New York Academy of Sciences

118

100

View full text Add to dashboard Cite

show abstract

“…Several studies have also compared the performance of HemoCue with different main laboratory analysers in ICU, during surgery or gastrointestinal bleeding episodes (Rippmann et al , ; Lardi et al , ; Gehring et al , ; Van de Louw et al , ; Mimoz et al , ; Lamhaut et al , ; Spielmann et al , ; Seguin et al , ). However, due to their small sample sizes and their extreme diversity in study design and methodologies, it is very difficult to evaluate the overall performance of HemoCue.…”

Section: Haemoglobin Poct In Hospital Settingsmentioning

confidence: 99%

“…However, due to their small sample sizes and their extreme diversity in study design and methodologies, it is very difficult to evaluate the overall performance of HemoCue. Some studies showed poor agreement in Hb levels (predominantly with capillary samples) between HemoCue and the mainstream laboratory analysers (Van de Louw et al , ; Seguin et al , ), whilst other studies reported more consistent results (McNulty et al , ; Gehring et al , ; Spielmann et al , ). Further, considering that the clinically acceptable Hb difference between different methods should be ≤10 g/l, it is evident that in some studies HemoCue has fallen short (Van de Louw et al , ; Rippmann et al , ; Lamhaut et al , ; Mimoz et al , ).…”

Section: Haemoglobin Poct In Hospital Settingsmentioning

confidence: 99%

Where are we at with point‐ of‐ care testing in haematology?

2012

View full text Add to dashboard Cite

Summary Point‐of‐care testing (POCT) in haematology has continued to grow in popularity and uptake throughout the world. The increasing demand to reduce the turnaround time of test results, coupled with rapid improvements in technology, have led to the development of several devices that are designed for use in different clinical settings, with the hope of improving patient care. The most used POCT in haematology is measurement of haemoglobin concentration. Other POCT devices (used primarily in developing countries) for malaria screening and CD4+ T‐lymphocytes for quantification of human‐immunodeficiency‐virus are becoming the cornerstone for the diagnosis and management of these disorders. New devices are also available for red cell indices, white blood cell count and platelets. In this review clinical studies that validate the use of such devices will be discussed, as well as the advantages and disadvantages of POCT in haematology. A disadvantage of POCT is a lack of training, poor standardization in obtaining blood samples and insufficient internal/external quality assessment. As there is every reason to expect that POCT use will increase in all pathology disciplines, including haematology, it is imperative that systems are put in place to oversee these issues.

show abstract

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

View full text Add to dashboard Cite

performed at home and results can be integrated by online interfaces. [5] The test results and diagnostic information can be analyzed by the medical professionals from remote locations, improving the connectivity of central hubs to the public venues.Numerous scientific discoveries have been made in advanced settings and wellequipped laboratories. The necessity and complexity of these environments limit access to research equipment worldwide. Thus, decentralization of research laboratories has become an alternative solution to improve access to experimentation in field conditions. For instance, a paper origami microscope [6] that fit into a palm of a student made a powerful investigation tool for environment and materials. A detailed analysis of sound recordings by smartphones enabled identification of distinct mosquitoes. [7] These fielddeployable devices and platforms have stimulated emergence of citizen scientists, a population that collectively performs scientific inquiries in public settings.Rich biomolecular measurements from field-portable devices improve the quality of results in terms of accuracy and depth. Monitoring multiple blood markers has enabled diagnostic precision and thorough scientific investigation of blood constituent in patients. Therefore, field-deployable devices should ideally have multiplexed detection of target specimens. Design of such multiplexed detection technologies requires decent complexity at low cost for wide-scale adoptability.In this article, we provide an overview of field-compatible devices with high parameter analysis capabilities for both health monitoring purposes and scientifically enlightening Global health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single-plex assays due to ease-of-use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point-of-care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowdsourced solutions, and robust user interfaces will become an integral ...

show abstract

Accuracy and precision of hemoglobin point‐of‐care testing during major pediatric surgery

Abstract: All POCT devices tested and operated by trained staff for hemoglobinometry showed reliable test results. They all allow for simple, fast, and precise bedside determination of hemoglobin concentration in the intraoperative setting.

Cited by 26 publications

References 13 publications

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Methods and analyzers for hemoglobin measurement in clinical laboratories and field settings

Where are we at with point‐ of‐ care testing in haematology?

Portable Multiplex Optical Assays

Contact Info

Product

Resources

About