Accumulation of zinc-phthalocyanine (Zn-Pc) in the aorta of atherosclerotic rabbits

Photodynamic therapy of arteries. A novel approach for treatment of experimental intimal hyperplasia.

“…[34][35][36][37][38] Recently, rabbits fed a cholesterol-rich diet have been found to accumulate injected Zn-PC in the atherosclerotic aorta. 39 In this experimental model of IH, the balloon catheter-induced injury to the CCA is followed by SMC replication and migration across the IEL into the intima, where cellular proliferation continues. During this process, SMCs undergo a change in phenotype, exhibiting ultrastructural and functional properties equivalent to the synthetic SMCs in culture.40 This change in phenotype and the replication and migration activities are noted in only approximately 50% of the medial SMCs.41 Thus, not all of the medial cells are committed to replicate and migrate, and 50% of them remain in the contractile phenotype.…”

Self‐Assembly of Drug‐Loaded Liposomes on Genetically Engineered Target‐Recognizing M13 Phage: A Novel Nanocarrier for Targeted Drug Delivery

“…In addition, the liposomes allow much smaller doses of drug to be used, thus reducing the side effects of that drug. On the other hand, zinc phthalocyanine (ZnPc) is a potential drug that is being tested as a photosensitizer for photodynamic therapy (PDT) 5. PDT involves the systemic administration of a photosensitizer followed by illumination with light of an appropriate wavelength, which results in the formation of singlet oxygen ( 1 O 2 ) for destroying cancer cells 6.…”

Photochemotherapy of Cancer: Experimental Research

“…The use of merocyanine 450 for purging autologuous bone marrow grafts, sterilization of blood products, and inactivation of leukemia cells and Herpes simplex virus type 1 is being investigated (Sieber, 1987;Gaffney and Sieber, 1990;Davila et al, 1991 and references cited therein). Furthermore, some photosensitizers accumulate in atheromatous plaques, which suggests that PCT through percutaneous catheterization may be used to treat atheromas (Verver-Bizet et al, 1989;Visona et al, 1989).…”