Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients

Katakami, Naoto; Kaneto, Hideaki; Matsuoka, Taka‐aki; Takahara, Mitsuyoshi; Imamura, K.; Ishibashi, Fukashi; Kanda, Tsutomu; Kawai, Koichi; Osonoi, Takeshi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Matsuhisa, Munehide; Shimomura, Iichiro; Yamasaki, Yoshimitsu

doi:10.1016/j.atherosclerosis.2010.06.010

Cited by 32 publications

(35 citation statements)

References 30 publications

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“…However, other studies have not confirmed these associations 20 . The minor allele variant of the rs1799983 G>T SNP of NOS3 gene may be associated with endothelial dysfunction and increased risk for coronary artery disease [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress

Fazakas

Szelényi

Szénási

et al. 2016

Journal of the American Society of Hypertension

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The role of oxidative stress (OXS) due to myocardial nitric oxide synthase (NOS) uncoupling related to oxidative depletion of its cofactor tetrahydrobiopterin (BH 4 ) emerged in the pathogenesis of heart failure with preserved ejection fraction (HFPEF).We determined the prevalence of 6 single nucleotide polymorphisms (SNPs) of genes encoding enzymes related to OXS, BH 4 metabolism and NOS function in >60-year-old 94 patients with hypertension and 18 age-matched controls with normal EF. Using echocardiography 56/94(60%) patients with hypertension had left ventricular (LV) diastolic dysfunction (HTDD+ group), 38/94(40%) patients had normal LV diastolic function (HTDDgroup). Four SNPs (rs841, rs3783641, rs10483639, rs807267) of guanosine triphosphate cyclohydrolase-1, the rate limiting enzyme in BH 4 synthesis, 1 (rs4880) of manganese superoxide dismutase, and 1 (rs1799983) of endothelial NOS genes were genotyped using real time PCR method and Taqman probes. Protein carbonylation (PC), BH 4 and total biopterin levels were measured from plasma samples. No between-groups difference in minor allele frequency (MAF) of SNPs was found. We calculated a genetic score indicating risk for OXS based on the MAFs of the SNPs. A high genetic risk for OXS was significantly associated with HTDD+ even after adjustment for confounding variables [OR(95%CI):4.79(1.12-20.54); p=0.035]. In both patient groups PC (p<0.05 for both), plasma BH 4 (p<0.01 for both) and in the HTDD+ group total biopterin (p<0.05) increased vs. controls. In conclusion, in patients with hypertension and normal EF, a potential precursor of HFPEF, a partly genetically determined increased OXS seems to be associated with the presence of LV diastolic dysfunction.key words: hypertension, heart failure with preserved ejection fraction, oxidative stress 3

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Section: Introductionmentioning

confidence: 99%

Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress

Fazakas

Szelényi

Szénási

et al. 2016

Journal of the American Society of Hypertension

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“…A total of 271 relevant references were included, with 257 publications excluded. One study (Katakami et al, 2009) was excluded since it was overlapped by another study with a larger scale (Katakami et al, 2010). Three publications did not meet the requirements of HWE (P HWE <0.05) (Mata-Balaguer et al, 2004;Morgan et al, 2007;Hashad et al, 2014).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Three publications did not meet the requirements of HWE (P HWE <0.05) (Mata-Balaguer et al, 2004;Morgan et al, 2007;Hashad et al, 2014). Finally, a total of 10 casecontrol studies were retrieved on ACS and the CYBA C242T polymorphism (Gardemann et al, 1999;Stanger et al, 2001;Yamada et al, 2002;Murase et al, 2004;Vasiliadou et al, 2006;Macías-Reyes et al, 2008;Katakami et al, 2010;de Caterina et al, 2011;Goliasch et al, 2011;Narne et al, 2012).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…All the included studies were conducted from 1999 to 2012, with 6102 ACS patients and 8669 controls. MI was employed as the primary endpoint in five studies (Yamada et al, 2002;Vasiliadou et al, 2006;Katakami et al, 2010;de Caterina et al, 2011;Goliasch et al, 2011), while MI and unstable angina were taken as the endpoint in two studies (Murase et al, 2004;Macías-Reyes et al, 2008). The endpoint of three studies was CAD, and MI was taken as the endpoint in subgroup analysis (Gardemann et al, 1999;Stanger et al, 2001;Narne et al, 2012).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

Huang

et al. 2015

J. Zhejiang Univ. Sci. B

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Background: A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS. Methods and results: We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64-0.83), dominant model (OR 0.71; 95% CI 0.62-0.82), and homozygote comparison (OR 0.57; 95% CI 0.35-0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger's linear regression test. Conclusions: Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians.

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“…However, the studies conducted are in con sistent. While Wiersma et al (4) found that the MPO level is meaningfully high, other studies did not find significant results (5,6). Myeloperoxidase is a product of a single 11 kb gene consisting of 11 introns and 12 exons (7).…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase and Glutamate-Cysteine Ligase Polymorphisms in Type 2 Diabetes Mellitus: A Preliminary Study / Polimorfizmi Mijeloperoksidaze I Glutamat-Cistein Ligaze U Diabetes Mellitusu Tipa 2: Preliminarna Studija

Eksi¹,

Karaali²,

Incekara³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: Oxidative stress can accompany the physiopathology of diabetes mellitus. Myeloperoxidase and glutamate-cysteine ligase catalytic subunit are two important substances which are connected with the maintaining of the redox balance in the body. In this study, the association between diabetes, lipid levels, myeloperoxidase -463G/A, and the glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms have been investigated. Methods: Frequencies of genotypes and alleles have been assessed using PCR-RFLP techniques in 90 type 2 diabetic patients and 70 healthy controls. Results: We found an association between myeloperoxidase -463 G/A genotype distributions (p=0.023) and allele distributions (p=0.009) in the study groups. In addition, there is a significant difference for each of the genotype (p=0.014) and allele (p=0.007) distributions for the glutamate-cysteine ligase catalytic subunit -3506A/G polymorphism. Conclusions: Our study reveals the first data about the myeloperoxidase -463G/A and glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms for type 2 diabetes and we believe that this work will play a pioneering role for further studies.

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Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients

Cited by 32 publications

References 30 publications

Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress

Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress

Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

Myeloperoxidase and Glutamate-Cysteine Ligase Polymorphisms in Type 2 Diabetes Mellitus: A Preliminary Study / Polimorfizmi Mijeloperoksidaze I Glutamat-Cistein Ligaze U Diabetes Mellitusu Tipa 2: Preliminarna Studija

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