Accumulation of cadmium in tissue and its effect on live performance

Akyolcu, Mehmet Can; Özçelik, Derviş; Dursun, Şefik; Toplan, Şerife; Kahraman, Recep

doi:10.1051/jp4:20030236

Cited by 15 publications

(10 citation statements)

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“…Chronic changes of kidney tissue were observed in the chickens with the highest concentration of Cd (724 mg/kg). Similar results were obtained by Akyolcu et al (2003). The average body weight of chickens exposed to Cd was significantly lower (P < 0.001) compared to the control group.…”

Section: Resultssupporting

confidence: 79%

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Model trial investigating retention in selected tissues using broiler chicken fed cadmium and humic acid

Herzig¹,

Navrátilová²,

Suchý³

et al. 2007

Vet. Med. - Czech

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Forty randomly selected chickens were allocated into four groups: K, HA, Cd and Cd + HA. After a 5-day adaptation period, the experiment was initiated. Group K was fed a diet without supplements. Group HA was fed the same diet with a 0.5 g supplement of humic acid per chicken/day. Group Cd was treated with 0.147 mg Cd per chicken/day (0.3 mg of CdCl 2 ·2.5H 2 O), and Group Cd + HA was given the same treatment as the latter group, with an additional 0.5 g humic acid per chicken/day. The chickens were given the above mentioned treatment daily, for 10 days. Subsequently, they were slaughtered and samples from livers, kidneys and leg muscle (m. flexor perforans et perforatus) were collected and Cd levels determined. The Cd levels detected in Group K are commonly found in market chickens and were assumed to be base background value; these represent 32%, 5.2% and 20% of allowed maximum residual limit (MRL) in kidney, liver and muscle, respectively. The limits are 1.0; 0.5 and 0.05 mg/kg for kidney, liver and muscle, respectively. The ten-day treatment with 0.147 mg Cd/day, i.e. 1.47 mg Cd per 10 days, significantly increased Cd levels in all investigated tissues. Average levels in kidneys, livers and leg muscle were 4.99 ± 1.57, 0.558 ± 0.630 and 0.052 ± 0.008 mg Cd/kg, respectively. When cadmium chloride was given together with humic acids, (group Cd + HA), Cd levels decreased in all investigated tissues by 39.6%, 34.2% and 80.8% in kidney, liver and muscle, respectively. The average levels were 3.012 ± 1.33, 0.361 ± 0.367 and < 0.01 mg/kg in kidneys, livers and leg muscle, respectively.

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Section: Resultssupporting

confidence: 79%

“…Cadmium mainly accumulates in the kidney and liver (Bokori et al, 1996;Akyolcu et al, 2003). The results confirmed significantly higher levels of cadmium in the parenchymatous organs when compared with muscle.…”

Section: Resultssupporting

confidence: 68%

Model trial investigating retention in selected tissues using broiler chicken fed cadmium and humic acid

Herzig¹,

Navrátilová²,

Suchý³

et al. 2007

Vet. Med. - Czech

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“…Cadmium is an environmental toxic heavy metal; a potential pollutant resulted from industrial and agricultural sources [27].The long biological half-life of cadmium makes Cd as a cumulative toxin, [28], which is primarily distributed to the liver and then redistributed to the kidney [29]. Selenium supplementation in poultry is associated with energy metabolism, increased feed efficiency, improved reproduction, and improved immune responses.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Studies on the Ameliorative Effects of Selenium and Vitamin E against Cadmium Toxicity in Chickens

Hashem

El-Dein

ELgelil

2019

Zagazig Veterinary Journal

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Cadmium (Cd) is one of the most dangerous environmental bioaccumulative heavy metals that concern a vital interest due to its injurious to animal and public health. An experimental trial was conducted for six weeks to evaluate the protective effect of selenium and /or vitamin E against the adverse effect of cadmium. One hundred and five, one day old broiler chicks were divided into five random groups. Group1 (negative control) was fed on basal diet; Group 2 was supplemented with 100 mg of cadmium /kg diet; Group 3 was supplied with 0.5 mg/kg diet of selenium; Group 4 was fed on 100 mg/kg diet of vitamin E and Group 5 was supplemented with Cd, Se and vitamin E combinations. The results revealed that cadmium group showed a highly significant increase in serum alanine amino transferase (ALT) and aspartate amino transferase (AST) (36±1.1and 220±3.53, respectively) activities, serum uric acid and creatinine (25.68±1.01 and 4.38±0.15, respectively) and a significant decrease in serum total proteins, albumin and globulins values (2.34±0.09, 1.14±0.05 and1.20±0.05, respectively) particularly at the end of the sixth week in comparable to the control group. In addition, a significant increase in serum malondialdehyde (MDA) and nitric oxide (NO) (3.9±0.09 and 51.33±0.88, respectively), a significant decrease in glutathione peroxidase (GSH-PX) values (0.05±0.005) associated with a significant reduction in interleukin 2 (IL2) and interleukin 10 (IL10) (1.8±0.30 and 7.4±0.43, respectively) values were reported specially at the end of the sixth week compared with the control group. Overall, our results showed an improvement in groups supplied with either Se or vitamin E when compared with cadmium group. In conclusion, supplementation of selenium or vitamin E alone didn't recover the depressive effect of Cd but their combination could improve its deleterious effect due to their antioxidant activity.

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“…These results are comparable with data from other studies. Using of (Akyolcu et al, 2003). Oxidative stress induced by Cd in chickens via the drinking water (25 mg Cd per L) for 6 weeks, plays a decisive role in a strong decrease in the performance of broiler (Erdogan et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Disturbance of the functionality in immunocompetent organs of chickens due to accumulation of cadmium

Vasiljeva¹,

N.²,

Смирнова³

2018

Research for Rural Development

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The high toxicity, bioaccumulative and increased distribution of cadmium (Cd) in the environment, makes it the most dangerous to any biological system, including immune system in human and animals. The effect of dietary intake of Cd (8.25 mg per kg) on accumulation and distribution of this heavy metal in various tissues, and functional changes in organs of immunity (thymus, bursa of Fabricius, spleen) in 35-day-old broiler cockerels were investigated, using biochemical and immunological methods. Significant increases in the Cd concentration both in central immunocompetent organs (thymus, bursa of Fabricius) and peripheral (spleen) were established. Excessive tissue level of Cd induced the prooxidative effect of this heavy metal in the organs. It was manifested in an increase of cell membrane lipid peroxidation (the enhanced malondialdehyde (MDA) concentration) in immune system organs. The oxidative stress resulted in immunocompetent cell damage. The fall of vital dye absorptive ability of immunocyte indicated the increase in the injured cell number. This harmful effect is in accordance with T-and B (C3)-population prominent depletion, organ relative mass reduction, and growth retardation in chicks, and was established as a result of dietary Cd loading for 5 weeks of the experiment.

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Accumulation of cadmium in tissue and its effect on live performance

Cited by 15 publications

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Model trial investigating retention in selected tissues using broiler chicken fed cadmium and humic acid

Model trial investigating retention in selected tissues using broiler chicken fed cadmium and humic acid

Clinicopathological Studies on the Ameliorative Effects of Selenium and Vitamin E against Cadmium Toxicity in Chickens

Disturbance of the functionality in immunocompetent organs of chickens due to accumulation of cadmium

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