Accidental Feeding of a Dilute Antiseptic Solution (Chlorhexidine 0.05% with Cetrimide 1%) to Five Babies

Mucklow, E. S.

doi:10.1177/096032718800700610

Cited by 21 publications

(17 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disinfectants and surfactants are used widely as an active ingredient in household and personal care products like dishwashing and laundry liquids, bleach and cosmetics that are commercially available in supermarkets. These products are daily necessities and accidental ingestion by old people or young children seems to have occurred more frequently than previously reported (Berkel and Wolff, ; Ohta et al , ; Wilson and Burr, ; Hironaga, ; Ichihara et al , ; Nagai et al , ; Mucklow, ; Balit et al , ; Ishigami et al , ; Kudo et al , ; Usui et al , ; Massano et al , ; Hirata and Kurokawa, ; Adelson and Sunshine, ; Hitosugi et al , ; Akutsu et al , ). The annual report of poisoning, required from 1998 to 2009 by The Japan Poison Information Center (), showed that household products were the highest poison hazards and their percentage of total causative materials was over than 64% every year.…”

Section: Discussionmentioning

confidence: 89%

“…Through utilizing our previously developed methods, concentrations of BZK, BZT and CHX in blood, lung, liver and kidney in rats were determined following a dose of 15 mg kg −1 intravascularly or 250 and 1250 mg kg −1 orally. Lung, liver and kidney were selected as tissue samples because these organs have been reported as affected tissues in human poisoning cases and in animal experiments (Xue et al , 2004a, b; Tiess and Nagel, ; Mucklow, ; Chow et al , ). The individual levels in blood and tissues at 24 h after administration were plotted.…”

Section: Resultsmentioning

confidence: 99%

“…Many cases of poisoning have occurred involving disinfectants and surfactants because they are easily accessible and have no purchase restrictions. Accidental ingestion by children or the elderly and suicidal ingestion of these compounds frequently occurs, resulting in serious poisoning symptoms (Berkel and Wolff, ; Ohta et al , ; Wilson and Burr, ; Hironaga, ; Ichihara et al , ; Nagai et al , ; Mucklow, ; Balit et al , ; Ishigami et al , ; Kudo et al , ; Usui et al , ; Massano et al , ; Hirata and Kurokawa, ) and sometimes death (Usui et al , ; Hirata and Kurokawa, ; Adelson and Sunshine, ; Hitosugi et al , ; Akutsu et al , ). Accidental intravascular administration is estimated to occur more frequently than the reported cases (Ishigami et al , ; Kudo et al , ; Usui et al , ; Wagner, ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats

Yang

Zhang

Tang

et al. 2011

J of Applied Toxicology

View full text Add to dashboard Cite

Accidental ingestion or injection of household products sometimes occurs due to their accessibility, but the toxic manifestations have not been well characterized when they are internally administered. The aim of this study was to investigate the toxic effects induced by ingestion or injection of different ionic surfactants and disinfectants in rats. The test drugs involved benzalkonium and benzethonium (BZK and BZT, both cationic surfactants used as disinfectants), alkyldiaminoethylglycine (AEG, an amphoteric surfactant used as a disinfectant), linear alkylbenzenesulfonate (LAS, an anionic surfactant), polyoxyethylene cetylether (PEC, a nonionic surfactant), chlorhexidine (CHX, not a surfactant but a disinfectant) and saline (control). Male Sprague-Dawley rats were administered one of the test drugs orally (p.o.), intravenously (i.v.) or intraarterially (i.a.). The fatal effects appeared rapidly (<30 min) in i.v.-administered rats, while taking hours (>5 h) in i.a./p.o.-administered rats after a dose of around LD(50) , although the progress and degree of toxic effects varied among the drugs tested. In intravascular administration, BZK and BZT were fatal at doses of 15-20 mg kg(-1) . Higher concentrations in lung and kidney than in blood were determined. CHX showed a high toxic effect compared with cationic surfactants. The rats administered anionic (LAS) or amphoteric (AEG) surfactant died in less than 24 h at doses over 100 mg kg(-1) . In p.o. administration, the toxic effects were concentration/dose-dependent, and all rats administered high doses of surfactants except for PEC died at 5-20 h. The overall toxic ranks could be: cationic surfactant/CHX> anionic/amphoteric surfactant > nonionic surfactant.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats

Yang

Zhang

Tang

et al. 2011

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…Cases of pulmonary and tongue edema and oral ulcers in infants who received 0.05% CHX orally after the antiseptic agent was mistaken for sterile water have been reported 30 . After developing respiratory distress syndrome, an elderly patient died due to ingestion of 10 g of CHX in a 200 mL solution 31 .…”

Section: Discussionmentioning

confidence: 99%

Evidence on the best chlorhexidine concentration to perform oral hygiene: meta-analysis

Gnatta¹,

Silveira²,

Lacerda³

et al. 2013

Mundo Saúde

View full text Add to dashboard Cite

Although scientific literature has demonstrated the relevance of oral hygiene with chlorhexidine in preventing ventilation--associated pneumonia, there is a wide variation of concentrations, frequency and techniques when using the antiseptic. The aim of this research was to assess the best chlorhexidine concentration used to perform oral hygiene to prevent ventilation-associated pneumonia. A systematic review followed by four meta-analysis using chlorhexidine concentration as criterion was carried out. Articles in English, Spanish or Portuguese indexed in the Cochrane, Embase, Lilacs, PubMed/Medline and Ovid electronic databases were selected. The research was carried out from May to June 2011. The primary outcome measure of interest was ventilation-associated pneumonia. Ten primary studies were divided in four groups (G1-4), based on chlorhexidine concentration criterion. G1 (5 primary studies, chlorhexidine 0.12%) showed homogeneity among studies and the use of chlorhexidine represented a protective factor. G2 (3 primary studies, chlorhexidine 0.20%) showed heterogeneity among studies and chlorhexidine did not represent a protective factor. G3 (2 primary studies, chlorhexidine 2,00%) showed homogeneity among studies and the use of chlorhexidine was significant. G4 (10 primary studies with different chlorhexidine concentrations) showed homogeneity among studies and the common Relative Risk was significant. Statistic analyses showed a protective effect of oral hygiene with chlorhexidine in preventing ventilation-associated pneumonia. However, it was not possible to identify a standard to establish optimal chlorhexidine concentration.Keywords: Oral Hygiene. Chlorhexidine. Pneumonia. Infection Control. Nursing. ResumoEmbora a literatura científica tenha demonstrado a importância da higiene bucal com clorexidina na prevenção de pneumonia associada à ventilação, existe uma grande variação das concentrações, frequência e técnica de aplicação do antisséptico. O objetivo desta pesquisa foi avaliar a melhor concentração de clorexidina usada para realizar a higiene bucal na prevenção de pneumonia associada à ventilação mecânica. Foi realizada uma revisão sistemática seguida de quatro meta-análises usando como critério a concentração de clorexidina. Foram selecionados artigos em Inglês, Espanhol ou Português indexados nas bases de dados eletrônicas: Cochrane, Embase, Lilacs, PubMed / Medline e Ovid. A pesquisa foi realizada no período de maio a junho de 2011. O desfecho primário de interesse foi a pneumonia associada à ventilação mecânica. Dez estudos primários foram divididos em 4 grupos (G1-4), com base no critério de concentração de clorexidina. G1 (5 estudos primários, clorexidina 0,12%) apresentaram homogeneidade e o uso de clorexidina demonstrou efeito protetor; G2 (3 estudos primários, clorexidina 0,20%) houve heterogeneidade entre os estudos e clorexidina não representou um fator de proteção; G3 (2 estudos primários, clorexidina 2,00%) homogeneidade entre os estudos e a utilização de clorexidina foi signif...

show abstract

“…31,33 There are case series that reported chlorhexidine accidental intake, and side effects resolved once exposure was interrupted. 34,35 …”

Section: Chlorhexidine Adverse Reactionsmentioning

confidence: 99%

Colonization and infection in the newborn infant: Does chlorhexidine play a role in infection prevention?

Rosario¹,

Puentes-Herrera

Corrales

et al. 2017

Arch Argent Pediat

View full text Add to dashboard Cite

Healthcare-associated infections are a major problem in newborn infants, considering their high morbidity, mortality, and long-term sequelae. In preterm infants, it has been shown that skin and gastrointestinal tract colonization undergoes variations compared to healthy term infants, and that preterm infants are more exposed to nosocomial microorganisms given their higher probability of being admitted to the neonatal intensive care unit where they are cared for. This document reviews normal colonization, the changes observed during hospitalization, prematurity, and the potential role of chlorhexidine in the prevention of resistant microorganism transmission, as well as its side effects in newborn infants admitted to the neonatal intensive care unit.

show abstract

Accidental Feeding of a Dilute Antiseptic Solution (Chlorhexidine 0.05% with Cetrimide 1%) to Five Babies

Cited by 21 publications

References 5 publications

Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats

Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats

Evidence on the best chlorhexidine concentration to perform oral hygiene: meta-analysis

Colonization and infection in the newborn infant: Does chlorhexidine play a role in infection prevention?

Contact Info

Product

Resources

About