Accidental fatal aflatoxicosis due to contaminated commercial diet in 50 dogs

Bruchim, Yaron; Segev, Gilad; Sela, U; Bdolah‐Abram, Tali; Salomon, Adi; Aroch, Itamar

doi:10.1016/j.rvsc.2011.07.024

Cited by 24 publications

(30 citation statements)

References 15 publications

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“…Although few data on mycotoxin toxicity in dogs are available, 19,20,51,52 it is possible to estimate the exposure degree and calculate the ADI and SPDL for mycotoxins ( Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…The IARC has classified naturally occurring mixtures of aflatoxins as carcinogenic to humans (Group 1) . In dogs, clinical signs include anorexia, depression, jaundice, melena, vomiting, diarrhea, coagulopathy and sudden death …”

Section: Introductionmentioning

confidence: 99%

“…15 In dogs, clinical signs include anorexia, depression, jaundice, melena, vomiting, diarrhea, coagulopathy and sudden death. 16,20 Mycotoxin occurrence in commercial feeds for dogs has been reported by several researchers, 21 -25 but there are few data on the natural exposure degree of dogs to mycotoxins in Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Exposure assessment of dogs to mycotoxins through consumption of dry feed

Bissoqui

Frehse

Freire

et al. 2016

J. Sci. Food Agric.

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“…Although few data on mycotoxin toxicity in dogs are available, 19,20,51,52 it is possible to estimate the exposure degree and calculate the ADI and SPDL for mycotoxins ( Table 3).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Bissoqui

Frehse

Freire

et al. 2016

J. Sci. Food Agric.

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“…Outbreaks related to pet food contaminated with aflatoxins have been described in several countries, including USA [6] and Israel [7], with corn as the usual source of aflatoxins in the feed. Although outbreaks caused by mycotoxins in pet animals have not been described in Brazil, a few cases of natural aflatoxicosis in dogs were reported in Rio Grande do Sul [8].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Occurrence of Aflatoxins and Fumonisins in Corn Intended for the Pet Feed Industry and for Human Consumption

Oliveira¹,

Cruz²,

Rosim³

et al. 2016

J Food Chem Nanotechnol

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“…Although the knowledge about the toxicological effects of mycotoxins in dogs and cats is still limited, some studies have shown that the presence of such substances in pet food can cause serious harm to pet health, with both acute and chronic forms of intoxication depending on the level of contamination and length of exposure (Leung et al, 2006;Boermans and Leung, 2007;Newman et al, 2007;Dereszynski et al, 2008;Bruchim et al, 2012;Wouters et al, 2013).…”

mentioning

confidence: 99%

Occurrence of mycotoxins in extruded commercial dog food

Gazzotti¹,

Biagi²,

Pagliuca³

et al. 2015

Animal Feed Science and Technology

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a b s t r a c tThe aim of this study was to determine the presence and the level of contamination of the most important mycotoxins (deoxynivalenol, fumonisin B 1 and B 2 , aflatoxin B 1 , B 2 , G 1 and G 2 , ochratoxin A and zearalenone) in 48 samples of extruded dry dog food found in the Italian market (24 samples from standard economy lines, 24 of premium lines). Analyses were performed using ultra-performance liquid chromatography coupled to tandem mass spectrometry. Although the concentrations of the mycotoxins in all samples proved to respect the European legislation with regards to animal feed, the analyses revealed a substantial presence of deoxynivalenol, fumonisins and ochratoxin A, with values above the limit of quantification (5 g/kg) in 100%, 88% and 81% of the samples, respectively. In contrast, aflatoxins and zearalenone contamination proved to be very modest, with 88% and 75% of the samples, respectively, showing concentrations below the corresponding limit of quantification (5 g/kg for aflatoxins and 10 g/kg for zearalenone). Moreover, despite a very heterogeneous contamination, the concentration of fumonisins and ochratoxin A was significantly higher in standard foods than in premiumones (491 vs. 80.2 g/kg dry matter for fumonisin B 1 ; 113 vs. 38.5 g/kg dry matter for fumonisin B 2 ; 599 vs. 103 g/kg dry matter for total fumonisins; 23.8 vs. 13.0 g/kg dry matter for ochratoxin A; P<0.001). Furthermore, a simultaneous presence of different mycotoxins (at concentrations higher than their limit of quantification) was observed in most of the pet foods analyzed; in particular, 19% of the samples were contaminated by no fewer than two different types of mycotoxins, 52% by three, 25% by four and 2% by all the mycotoxins evaluated. These results revealed the need for further investigation into the potential risk deriving from chronic exposure to low doses of the different types of mycotoxins that pet species are subject to today.

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Accidental fatal aflatoxicosis due to contaminated commercial diet in 50 dogs

Cited by 24 publications

References 15 publications

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Simultaneous Occurrence of Aflatoxins and Fumonisins in Corn Intended for the Pet Feed Industry and for Human Consumption

Occurrence of mycotoxins in extruded commercial dog food

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