Acceleration of wound healing by topical application of honey

Bergman, Arieh; Yanai, Joseph; Weiss, Jerry; Bell, David A.; David, Menachem P.

doi:10.1016/0002-9610(83)90204-0

Cited by 197 publications

(122 citation statements)

References 11 publications

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“…Wounds that contain more than 10 5 organisms per gram of tissues will not support a skin graft. In addition, an infection at the graft donor site can convert a partial-thickness dermal loss into a full-thickness skin loss [6,12,[20][21][22][23]. In our study, honey significantly decreased infection rate on the fifth day.…”

Section: Discussionmentioning

confidence: 58%

“…4 Contraction rate of graft in 1 month in two fixation groups graft to the burn wound bed and prevents from hematoma and seroma formation. This is due to adhesive properties of honey [6,12,[20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…After having played an important part in the traditional medicine for centuries, honey was subjected to laboratory and clinical investigations during the past few decades [3][4][5]. The most remarkable discovery was the antibacterial activity of honey that has been confirmed in numerous studies [4,6]. This antibacterial activity is related to four properties of honey.…”

Section: Introductionmentioning

confidence: 99%

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Honey: A Skin Graft Fixator Convenient for Both Patient and Surgeon

Maghsoudi¹,

Moradi

2014

Indian J Surg

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Skin grafts can be used effectively to cover burn injuries. A critical element of this treatment is the adherence of the graft to the wound bed. Honey has been shown to increase the adherence of skin grafts to wound beds and have antibacterial and anti-inflammatory effects and increase healing rate of wounds. We therefore devised a clinical trial to determine the effect of honey on skin graft fixation in burn injuries. Sixty patients were included in this study (in 30 patients, graft was fixed with medical honey, and in 30 patients, it was fixed with dressing or suturing). All patients in two groups were evaluated for infection, graft loss, graft contraction, severity of pain, and need for re-operation. The most common cause of burn was kerosene. Honey significantly decreased infection rate on fifth day and reduced the patient pain. The mean hospital stay was shorter in honey group. Contraction of graft was significantly less in honey group. Honey has strong adhesive properties for skin graft fixation. Medical honey is a natural material, not synthetic. For this reason, we can advise the application of medical honey for the fixation of split thickness skin graft.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Honey: A Skin Graft Fixator Convenient for Both Patient and Surgeon

Maghsoudi¹,

Moradi

2014

Indian J Surg

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“…The clinical applications of honey, particularly in the treatment of wounds, ulcers and burns are quite striking. It has been reported that honey promotes wound epithelization (Efem, 1993;Bergman, 1983;Efem, 1988;Subrahmanyam, 1988;Suguna, 1993), reduce inflammation (Subrahmanyam, 1998), edema (Efem, 1993;Efem, 1988;Gunther, 2010) and exudation (Efem, 1993;Efem, 1988), and accelerates synthesis of collagen and increase DNA content of the granulation tissue (Suguna, 1993;Lu et al, 2005;Ozlugedik, 2006;Koo et al, 2002;Park et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Medical Dressing Treated with Honey/Chitosan Microencapsules

Elnagar

Nagi

El-Gamal

2012

IJC

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Wound normally left to dry and dressing keeps infections out as well as reducing the trauma. Advanced technology is used to reduce pain and fast healing with avoiding the deformation of the injured skin. In this work previously UV/ozone irradiated medical dressing samples were treated by honey capsulated in chitosan. Treatment conditions were optimized with respect to weight; air-permeability; whiteness; yellowness and antibacterial. All treated samples showed good antimicrobial performance with sufficient air permeability and weight. The sticky nature of the honey was avoided by formation of microencapsules. Treated gauze samples showed good performance for injured rates with no inflammation.

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“…Lau (1976) reported that honey was listed in the first medical handbook 2000years ago to be used in burns, cuts and abscesses. Bergman et al (1983) reported that honey was used by Russian soldiers in the First World War, to accelerate wound healing. Therapeutic effects and potentials of honey in modern medicine suffered a set back due to lack of systematic scientific studies.…”

Section: Introductionmentioning

confidence: 99%

Bile secretion in albino rat following chronic honey intake

Ea¹,

Okwari²,

Ee³

2010

Nig. J. Phys Sci

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Summary:This study was carried out to evaluate the effect of honey intake on bile secretion, bile electrolytes, bilirubin and cholesterol levels including plasma cholesterol in albino rats. 20 male albino rats (200-210g) were used in the study. The rats were assigned randomly into 2 groups (control and honey-fed groups), each group containing 10 rats. The control was fed on normal rat feed and water while the test group was fed on normal rat feed with honey added to its drinking water (1ml of honey to every initial 10ml of water) for 22 weeks. After 22 weeks the animals were starved for 12hrs before the experiment, weighed and anaesthetized with sodium thiopentone (6mg/100mg body weight) intraperitoneally. The common bile duct was cannulated and bile collected for 3hrs. The rate of bile flow was noted, the concentrations of bile electrolytes and bilirubin, bile and plasma cholesterol levels were determined in the control and test groups. The results obtained showed a significant (P<0.05) decrease in the rate of bile flow in the test (0.30±0.03ml/hr) compared with the control groups (0.45± 0.04ml/hr). There were no significant differences in the concentration of bile electrolytes and bilirubin in the two groups. However, there was a significant (P<0.05) increase in the bile cholesterol and decrease in plasma cholesterol levels in the test rats compared with the control. It is therefore concluded that chronic consumption of unprocessed Nigerian honey resulted in decrease bile flow, increase bile cholesterol and decrease plasma cholesterol in albino rats.

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Acceleration of wound healing by topical application of honey

Cited by 197 publications

References 11 publications

Honey: A Skin Graft Fixator Convenient for Both Patient and Surgeon

Honey: A Skin Graft Fixator Convenient for Both Patient and Surgeon

Medical Dressing Treated with Honey/Chitosan Microencapsules

Bile secretion in albino rat following chronic honey intake

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