Summary:This study was carried out to evaluate the effect of honey intake on bile secretion, bile electrolytes, bilirubin and cholesterol levels including plasma cholesterol in albino rats. 20 male albino rats (200-210g) were used in the study. The rats were assigned randomly into 2 groups (control and honey-fed groups), each group containing 10 rats. The control was fed on normal rat feed and water while the test group was fed on normal rat feed with honey added to its drinking water (1ml of honey to every initial 10ml of water) for 22 weeks. After 22 weeks the animals were starved for 12hrs before the experiment, weighed and anaesthetized with sodium thiopentone (6mg/100mg body weight) intraperitoneally. The common bile duct was cannulated and bile collected for 3hrs. The rate of bile flow was noted, the concentrations of bile electrolytes and bilirubin, bile and plasma cholesterol levels were determined in the control and test groups. The results obtained showed a significant (P<0.05) decrease in the rate of bile flow in the test (0.30±0.03ml/hr) compared with the control groups (0.45± 0.04ml/hr). There were no significant differences in the concentration of bile electrolytes and bilirubin in the two groups. However, there was a significant (P<0.05) increase in the bile cholesterol and decrease in plasma cholesterol levels in the test rats compared with the control. It is therefore concluded that chronic consumption of unprocessed Nigerian honey resulted in decrease bile flow, increase bile cholesterol and decrease plasma cholesterol in albino rats.
Respiratory and Non-respiratory symptoms/sign in exposed Camphor industrial workers in Aba, Abia State, South East Nigeria, were studied. 100 selected Igbo women, working in Camphor industry for over 15 years were studied and they constitute the test group. They were compared with control subjects not exposed to Camphor or any known air pollutants. Both subjects were aged 25-50 years and weighed between 50-70 kg. Respiratory symptoms studied include dry unproductive cough, productive sputum cough, running/nasal congestion, sneezing, breathlessness, wheeze and chest pain. Non-respiratory symptoms investigated include feeling hot, general body pain, waist pain, internal heat, night fever, excessive sweating, occasional vomiting, abdominal ache, heat rashes, insomnia and blood pressure. The study lasted 3 months and was carried out using questionnaires and other necessary instruments after obtaining their consents. Results obtained showed that all respiratory symptoms in the study subjects (test) were highly significant when compared with control subjects (P<0.001). In non-respiratory symptoms, vomiting, abdominal ache and blood pressure in both the test and control were not statistically significant (P>0.05), others were statistically significant when the test subjects were compared with control (P<0.05). It was concluded that Camphor has significant effects on respiratory and non-respiratory symptoms/signs in exposed Camphor industrial workers.
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