Bile secretion in albino rat following chronic honey intake

Abstract

Summary:This study was carried out to evaluate the effect of honey intake on bile secretion, bile electrolytes, bilirubin and cholesterol levels including plasma cholesterol in albino rats. 20 male albino rats (200-210g) were used in the study. The rats were assigned randomly into 2 groups (control and honey-fed groups), each group containing 10 rats. The control was fed on normal rat feed and water while the test group was fed on normal rat feed with honey added to its drinking water (1ml of honey to every initial 10ml of water) for 22 weeks. After 22 weeks the animals were starved for 12hrs before the experiment, weighed and anaesthetized with sodium thiopentone (6mg/100mg body weight) intraperitoneally. The common bile duct was cannulated and bile collected for 3hrs. The rate of bile flow was noted, the concentrations of bile electrolytes and bilirubin, bile and plasma cholesterol levels were determined in the control and test groups. The results obtained showed a significant (P<0.05) decrease in the rate of bile flow in the test (0.30±0.03ml/hr) compared with the control groups (0.45± 0.04ml/hr). There were no significant differences in the concentration of bile electrolytes and bilirubin in the two groups. However, there was a significant (P<0.05) increase in the bile cholesterol and decrease in plasma cholesterol levels in the test rats compared with the control. It is therefore concluded that chronic consumption of unprocessed Nigerian honey resulted in decrease bile flow, increase bile cholesterol and decrease plasma cholesterol in albino rats.

Laying Performance, Survival Rate, Egg Quality and Shell Characteristics in Laying Pullets Offered Honey in Drinking Water during Hot Season

“…This may result in non-alcoholic fatty liver disease or in other unpleasant conditions harmful to health if abused. Alagwu et al (2009) had earlier stated that chronic consumption of unprocessed Nigerian honey resulted in decreased bile flow, increased bile cholesterol and decreased plasma cholesterol in albino rats.…”

Impacts of Climate Change to Poultry Production in Africa: Adaptation Options for Broiler Chickens

“…Honey is good but must be used with caution, especially in its application in poultry production. In literature, it has been reported that there were infiltrations of fat cells in the liver tissue of rats which was dosage-dependent (Avwioro et al 2012), decreased bile flow, increased bile cholesterol, and decreased plasma cholesterol (Alagwu et al 2009) in Albino rats and hypertrophy of follicle, giving it a deformed shape instead of the usual round shape in laying chickens (Abioja and Adekunle 2018). The authors concluded that chronic consumption of honey may increase the risk of hepatic damage.…”

Honey Composition, Therapeutic Potential and Authentication through Novel Technologies: An Overview

“…Honey also affects the HDL, LDL, VLDL, and total cholesterol, thus reducing the risk of heart disease. An animal trial showed a decrease in serum LDL and an increase in HDL, VLDL, and TG in comparison with Honey Composition, Therapeutic Potential and Authentication through Novel Technologies:… DOI: http://dx.doi.org/10.5772/intechopen.110007 the control, concluding that the honey can improve lipid profile and decrease the cardiac disease risk (Figure 1) [43].…”