Accelerated wound healing with an ionic patch assisted by a triboelectric nanogenerator

Jeong, Sunjoo; Lee, Younghoon; Lee, Min-Gyu; Sun, Jeong‐Yun; Park, Ji‐Ung; Sun, Jeong‐Yun

doi:10.1016/j.nanoen.2020.105463

Cited by 118 publications

(128 citation statements)

References 37 publications

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“…Electrical stimulation is an effective method to hasten the tissue regeneration process by, among others, accelerating neutrophil migration to the wound site and stimulating fibroblast proliferation [69]. W-TENGs can convert local biomechanical energy into electricity, generating periodic electrical stimulations that facilitate the tissue regeneration process in a convenient and sustainable manner [70][71][72].…”

Section: Tissue Regenerationmentioning

confidence: 99%

Wearable Triboelectric Nanogenerators for Therapeutics

Xiao

Chen

Libanori

et al. 2021

Trends in Chemistry

108

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Section: Tissue Regenerationmentioning

confidence: 99%

Wearable Triboelectric Nanogenerators for Therapeutics

Xiao

Chen

Libanori

et al. 2021

Trends in Chemistry

108

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“…The biostable and conductive PGCNSH can also deliver electrical stimulation in vivo, which brings about a synergetic therapeutic effect on chronic wounds. The diabetic wound, a typical chronic non-healing wound that significantly endangers patients' health, [53,54] was chosen as the model to investigate electrotherapy using the PGCNSH (Figure 5g; Figure S21, Supporting Information). By comparing the groups with and without electrical stimulation (ES), we found that wounds in ES groups exhibited faster wound closure (Figure 5h,i).…”

Section: Pgcnsh For Electrical-stimulated Therapy On Diabetic Woundmentioning

confidence: 99%

Conductive Cellulose Bio‐Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics

Yan

Zhou

Han

et al. 2021

Adv Funct Materials

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Biostable electronic materials that can maintain their super mechanical and conductive properties, even when exposed to biofluids, are the fundamental basis for designing reliable bioelectronic devices. Herein, cellulose-derived conductive 2D bio-nanosheets as electronic base materials are developed and assembled into a conductive hydrogel with ultra-high biostability, capable of surviving in harsh physiological environments. The bio-nanosheets are synthesized by guiding the in situ regeneration of cellulose crystal into a 2D planar structure using the polydopamine-reduced-graphene oxide as supporting templates. The nanosheet-assembled hydrogel exhibits stable electrical and mechanical performances after undergoing aqueous immersion and in vivo implantation. Thus, the hydrogel-based bioelectronic devices are able to conformally integrate with the human body and stably record electrophysiological signals. Owing to its tissue affinity, the hydrogel further serves as an "E-skin," which employs electrotherapy to aid in the faster healing of chronic wounds in diabetic mice through transcutaneous electrical stimulation. The nanosheet-assembled biostable, conductive, flexible, and cell/tissue affinitive hydrogel lays a foundation for designing electronically and mechanically reliable bioelectronic devices.

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“…In addition to the above treatment methods based on the release of therapeutic agents, electrical stimulation therapy by triboelectric nanogenerator (TENG) and thermal therapy by materials with electro-thermal properties have also been widely studied and applied in clinical practice. [111,112] Based on these significant advances, traditional hospital-centered wound management requiring patients to travel to a local clinic is shifting its focus toward the fabrication of multifunctional and self-sustainable wound dressings, with emphases on long-term continuously monitoring, early diagnosis, and timely treatment, all of which are highly beneficial for both patients and clinicians.…”

Section: Intelligent Materials and Devices For Wound Treatmentmentioning

confidence: 99%

Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Tang

Zheng

Cui

et al. 2021

Adv Healthcare Materials

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A wound dressing is a sterile pad or compress that is used in direct contact with a wound to help it heal and prevent further issues or complications. Though wound healing is an intricate dynamic process that involves multiple biomolecular species, conventional wound dressings have a limited ability to provide timely information of abnormal conditions, missing the best time for early treatment. The current perspective presents and discusses the design and development of smart wound dressings that are integrated with multifunctional materials, wearable sensors and drug delivery systems as well as their application ranging from wound monitoring to timely application of therapeutics. The perspective also discusses the ongoing challenges and exciting opportunities associated with the development of wearable sensor-based smart wound dressing and provide critical insights into wound healing monitoring and management.

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Accelerated wound healing with an ionic patch assisted by a triboelectric nanogenerator

Cited by 118 publications

References 37 publications

Wearable Triboelectric Nanogenerators for Therapeutics

Wearable Triboelectric Nanogenerators for Therapeutics

Conductive Cellulose Bio‐Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics

Multifunctional Dressing for Wound Diagnosis and Rehabilitation

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