Wearable Triboelectric Nanogenerators for Therapeutics

Xiao, Xiao; Chen, Guorui; Libanori, Alberto; Chen, Jun

doi:10.1016/j.trechm.2021.01.001

Cited by 116 publications

(74 citation statements)

References 77 publications

(99 reference statements)

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“…Photobased therapies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have recently been developed as promising therapeutic strategies for antitumor therapy because of their minimal invasiveness, low side effects, and high specificity [1][2][3][4][5][6]. For PTT and PDT, they usually utilize the near-infrared (NIR) laser-induced capability of photothermal agents and photosensitizers (PSs) to generate heat or cytotoxic singlet oxygen ( 1 O 2 ), which subsequently causes cell apoptosis [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Cai

Wang

et al. 2021

Research

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Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen (1O2) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. In this paper, a simple and effective multimodal therapeutic system was designed via combining chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain. IR-780 (IR780) dye-labeled tube-forming peptoids (PepIR) were synthesized and self-assembled into crystalline nanotubes (PepIR nanotubes). These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density; thus, a self-quenching of these IR780 molecules was significantly reduced. Moreover, the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells. Given the unique properties of peptoids and peptoid nanotubes, we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.

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Section: Introductionmentioning

confidence: 99%

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Cai

Wang

et al. 2021

Research

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“…In recent years, TENGs have emerged as a compelling technology to harness passive human biomechanical motions. [59,82,83] The working principle of TENGs is based on the coupling effect of contact electrification and electrostatic induction, which can be traced back to the Maxwell equations. As shown in Figure 2c, TENGs can operate in four working modes, including vertical contact-separation mode, linear sliding mode, single-electrode mode, and freestanding triboelectric layer mode.…”

Section: Tengsmentioning

confidence: 99%

“…[50][51][52] With a collection of compelling features including flexibility, [53] wearability, [54] lightweight, [55] low cost, [56] conformability, [57] and biocompatibility, [58] TENGs have great potential for energy harvesting, sensing, and therapeutic applications. [59][60][61][62][63] This radically new technology is also becoming one of the most promising approaches for portable wound healing, which provides both efficient electrical stimulation therapeutics and sustainable power for wound healing devices, and frees patients from dependency on health facilities. [64,65] Herein, we comprehensively highlight the current advances of TENG-based wound healing via means of different mechanisms, including cell proliferation and migration, antibacterial, and drug delivery (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Triboelectric Nanogenerators for Self‐Powered Wound Healing

Xiao

Nashalian

Libanori

et al. 2021

Adv Healthcare Materials

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Wound healing, one of the most complex processes in the human body, involves the spatial and temporal synchronization of a variety of cell types with distinct roles. Slow or nonhealing skin wounds have potentially life-threatening consequences, ranging from infection to scar, clot, and hemorrhage. Recently, the advent of triboelectric nanogenerators (TENGs) has brought about a plethora of self-powered wound healing opportunities, owing to their pertinent features, including wide range choices of constitutive biocompatible materials, simple fabrication, portable size, high output power, and low cost. Herein, a comprehensive review of TENGs as an emerging biotechnology for wound healing applications is presented and covered from three unique aspects: electrical stimulation, antibacterial activity, and drug delivery. To provide a broader context of TENGs applicable to wound healing applications, state-of-the-art designs are presented and discussed in each section. Although some challenges remain, TENGs are proving to be a promising platform for human-centric therapeutics in the era of Internet of Things. Consequently, TENGs for wound healing are expected to provide a new solution in wound management and play an essential role in the future of point-of-care interventions.

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“…Self-powered sensors based on emerging triboelectric nanogenerator technology have been demonstrated to possess promising sensing capabilities with numerous advantages, such as simple structure, high robustness, and low cost (Wang, 2014;Pu et al, 2017;Zhang et al, 2017;Xiao et al, 2021;Zhao et al, 2021;Conta et al, 2021;Peng, 2021;Mahmud et al, 2021;Chen et al, 2016;Yan, 2020;Xu et al, 2020). Such sensors are capable of generating significant electrical signals in response to ambient stimuli without external power supply (Huang et al, 2021;Su et al, 2020a;Tat et al, 2021;Zou et al, 2020;Zou, 2021).…”

Section: Introductionmentioning

confidence: 99%

A portable triboelectric spirometer for wireless pulmonary function monitoring

Fang

Jing

et al. 2021

Biosensors and Bioelectronics

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free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website.Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Wearable Triboelectric Nanogenerators for Therapeutics

Cited by 116 publications

References 77 publications

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Triboelectric Nanogenerators for Self‐Powered Wound Healing

A portable triboelectric spirometer for wireless pulmonary function monitoring

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