Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Tang, Ning; Zheng, Youbin; Cui, Daxiang; Haick, Hossam

doi:10.1002/adhm.202101292

Cited by 66 publications

(52 citation statements)

References 111 publications

(130 reference statements)

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“…The glucose sensor was calibrated in a concentration range between 200 × 10 −6 and 4 × 10 −3 m (Figure 4c; Figure S17a, Supporting Information), which correspond to the concentrations of glucose in the typical wound milieu of chronic and healing wounds. [2] In the range of 0 to 2 × 10 −3 m, this glucose sensor exhibited excellent linearity; the sensitivity coefficient (SC) calculated from the slope of linear fitting curve was equal to ≈1.72 µA mm −1 , where the regression coefficient (r 2 ) was 0.968 (Figure 4d). The glucose sensor was stable after ten times successive tests, demonstrating good repeatability (Figure S17b, Supporting Information).…”

Section: In Vitro Assessment Of Sensor Array In Multifunctional Wound Dressingmentioning

confidence: 88%

“…[30][31][32] These wearable devices enable continuous point-of-care wound monitoring, [33,34] leading for a better management of the would assessement, as compared to traditional appraoches based on a visual evaluation of the bed color, which requires removal of the wound dressing beforehand. [2,35] Recent developments of smart wound dressings for real-time monitoring and controllable drug delivery have been reported. [36][37][38] However, much less effort has been put into dressings for sutureless wound closure and for effective promotion of healing.…”

Section: Introductionmentioning

confidence: 99%

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Highly Efficient Self‐Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

et al. 2021

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A common auxiliary method in wound management is the closure step, viz. the restoration of the skin function through reconnecting the wounded tissues. [4] Medical sutures and staples are the most commonly used approaches when joining wound edges. [5] However, these methods are highly invasive and can have detrimental consequences on the surrounding tissues. [6,7] In addition, these methods require professional skills and equipment, limiting their general use outside the hospital. [8] Alternative tissue connecting techniques such as Zipline, a minimal/ noninvasive wound closure device, have been investigated and publicized. [9] Nevertheless, these treatments keep the wound exposed to the environment, resulting in an increased risk of infection, and hindering wound healing. [10] Gauzes, cotton wools, and bandages that are commonly used to close wounds by wrapping or pressing are unreliable and ineffective when treating large injuries. [11,12] Therefore, there is an urgent need for multipurpose materials that combine noninvasive wound closure and dressing functions that can promote healing.Inspired by living systems, several materials with promising self-healing ability have been designed and synthesized for Wound healing represents a major clinical and public healthcare problem that is frequently challenged by infection risks, detrimental consequences on the surrounding tissues, and difficulties to monitor the healing process.Here we report on a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring of the healing parameters. The self-healing elastomer contains cetyltrimethylammonium bromide (CTAB) and has high mechanical toughness (35 MJ m −3 ), biocompatibility, and outstanding antibacterial activity (bactericidal rate is ≈90% in 12 h), enabling the wound dressing to effectively inhibit bacterial growth and accelerate infected wound healing. In vivo tests based on full-thickness skin incision model shows that the multifunctional wound dressing can help in contracting wound edges and facilitate wound closure and healing, as could be evidenced by notably dense and well-organized collagen deposition. The test provides an evidence that the integrated sensor array within the multifunctional wound dressing can monitor temperature, pH, and glucose level of the wound area in real-time, providing reliable and timely information of the condition of the wound. Ultimately, the reported multifunctional dressing would be of high value in managing the burden associated with wound healing via personalised monitoring and treatment approaches, digital and other people-centred solutions for health care.

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Section: In Vitro Assessment Of Sensor Array In Multifunctional Wound Dressingmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Highly Efficient Self‐Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

et al. 2021

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“…The wound healing of human skin is a complex process usually divided into three stages [2,7,8] : (1) the hemostasis and inflammation stage [Figure 2A]; (2) the proliferation stage [Figure 2B]; and (3) the remodeling stage [Figure 2C] [9] , overlapping in time and space [Figure 2D] [10] . (1) Hemostasis and Inflammation stage: This stage includes the immediate initiation of hemostasis after tissue damage followed by constriction of blood vessels near the wound site, aggregation of blood platelets to form a platelet clot followed by the formation of fibrin matrix cleaved from fibrinogen during coagulation of blood [2,8,11] . The platelet plug and fibrin matrix formation leads to the release of cytokines and growth factors that cause an inflammatory reaction essential to tackle pathogens, bacteria, or toxins and initiate the repair process.…”

Section: Wound Healing Mechanism and Biomarkersmentioning

confidence: 99%

“…A break or defect of skin tissue is called a wound, and a wound that does not heal in the normal time frame is defined as a chronic wound. The lack of therapies that hasten the healing of chronic wounds can result in further wound complications, including infection and even amputation [1,2] . Therefore, timely and effective management of chronic wounds is crucial to accelerate wound healing and relieve the patient's pain.…”

Section: Introductionmentioning

confidence: 99%

Wearable electronics for skin wound monitoring and healing

Patel¹,

Ershad²,

Zhao³

et al. 2022

Soft Sci

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Wound healing is one of the most complex processes in the human body, supported by many cellular events that are tightly coordinated to repair the wound efficiently. Chronic wounds have potentially life-threatening consequences. Traditional wound dressings come in direct contact with wounds to help them heal and avoid further complications. However, traditional wound dressings have some limitations. These dressings do not provide real-time information on wound conditions, leading clinicians to miss the best time for adjusting treatment. Moreover, the current diagnosis of wounds is relatively subjective. Wearable electronics have become a unique platform to potentially monitor wound conditions in a continuous manner accurately and even to serve as accelerated healing vehicles. In this review, we briefly discuss the wound status with some objective parameters/biomarkers influencing wound healing, followed by the presentation of various novel wearable devices used for monitoring wounds and accelerating wound healing. We further summarize the associated device working principles. This review concludes by highlighting some major challenges in wearable devices toward wound healing that need to be addressed by the research community.

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“…Some recent studies implemented bandages to autonomously release drugs according to the real-time physiological conditions of the wound [ 25 ], forming a complete closed-loop of wound detection and treatment, which would be highly beneficial for patients suffering from chronic wounds. Although other review articles also mentioned smart bandages [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ], they mainly focused on the applicability of flexible composites in the wound environment or drug delivery devices. Considering that the detection function is the foundation of the entire smart bandage system, we provide a comprehensive and detailed summary of the key markers in wounds and the methods of wound detection by flexible wearable sensors ( Figure 1 ) based on optical and electrical sensing.…”

Section: Introductionmentioning

confidence: 99%

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

Sun

Zhang

et al. 2021

Biosensors

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Chronic wounds that are difficult to heal can cause persistent physical pain and significant medical costs for millions of patients each year. However, traditional wound care methods based on passive bandages cannot accurately assess the wound and may cause secondary damage during frequent replacement. With advances in materials science and smart sensing technology, flexible wearable sensors for wound condition assessment have been developed that can accurately detect physiological markers in wounds and provide the necessary information for treatment decisions. The sensors can implement the sensing of biochemical markers and physical parameters that can reflect the infection and healing process of the wound, as well as transmit vital physiological information to the mobile device through optical or electrical signals. Most reviews focused on the applicability of flexible composites in the wound environment or drug delivery devices. This paper summarizes typical biochemical markers and physical parameters in wounds and their physiological significance, reviews recent advances in flexible wearable sensors for wound detection based on optical and electrical sensing principles in the last 5 years, and discusses the challenges faced and future development. This paper provides a comprehensive overview for researchers in the development of flexible wearable sensors for wound detection.

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Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Cited by 66 publications

References 111 publications

Highly Efficient Self‐Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

Highly Efficient Self‐Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

Wearable electronics for skin wound monitoring and healing

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

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