Ação do ultra-som de baixa intensidade em ossos de ratas osteopênicas.

Carvalho, Daniela Cristina Leite de

doi:10.11606/d.82.2001.tde-31082001-165952

Cited by 21 publications

(19 citation statements)

References 40 publications

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“…Hormonal deficiency tends to increase the stiffness coefficient, making the bone more fragile or brittle. Similar to previous results [8, 25, 26], ZA could maintain and even reduce the bone stiffness coefficients of the oophorectomized animals in the present study (group OZA) to levels similar to those of the non-oophorectomized animals (group SZA). These results suggest that the drug maintained the absolute (i.e., organic and inorganic) bone integrity, which would explain the decrease in the femoral stiffness coefficient.…”

Section: Discussionsupporting

confidence: 92%

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Palácio

Müller

Sardenberg

et al. 2012

Journal of Osteoporosis

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Aim. To investigate the biomechanical effects of zoledronic acid (ZA) on femurs of female osteoporotic rats after follow-up periods of 9 and 12 months. Methods. Eighty female Wistar rats were prospectively assessed. At 60 days of age, the animals were randomly divided into two groups: bilateral oophorectomy (O) (n = 40) and sham surgery (S) (n = 40). At 90 days of age, groups O and S were randomly subdivided into four groups, according to whether 0.1 mg/kg of ZA or distilled water (DW) was intraperitoneally administered: OZA (n = 20), ODW (n = 20), SZA (n = 20), and SDW (n = 20). The animals were sacrificed at 9 and 12 months after the administration of the substances, and then their right femurs were removed and analyzed biomechanically. Axial compression tests that focused on determining the maximum load (N), yield point (N), and stiffness coefficient (N/mm) of the proximal femur were performed in the biomechanical study. Results. ZA significantly increased the maximum load and yield point, reducing the stiffness coefficient concerning the oophorectomy status and follow-up period. Conclusion. Zoledronic acid, at a dose of 0.1 mg/kg, significantly increased the maximum loads and yield points and reduced the stiffness coefficients in the femurs of female rats with osteoporosis caused by bilateral oophorectomy.

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Section: Discussionsupporting

confidence: 92%

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Palácio

Müller

Sardenberg

et al. 2012

Journal of Osteoporosis

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“…Achados semelhantes foram obtidos por outros autores (26,29,30) . Após o climatério, em função da alteração não apenas da distribuição de tecido adiposo, causado pela deficiência de estrógenos, mas também pelo acú-mulo periférico de gordura, ocorre alteração do perfil lipídico e aumento da massa corporal (31) .…”

Section: Discussionunclassified

Efeito do ácido zoledrônico em tíbias de ratas ooforectomizadas: estudo prospectivo e randomizado

Pereira¹,

Dutra²,

Olímpio³

et al. 2009

Rev. bras. ortop.

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Objetivo: Investigar as repercussões clínicas, biomecânicas e histomorfométricas do ácido zoledrônico em tíbias de ratas osteoporóticas, após ooforectomia bilateral. Métodos: Foram estudadas, prospectivamente, 40 ratas da linhagem Wistar (Rattus novergicus albinus). Com 60 dias de vida, os animais foram aleatorizados em dois grupos de acordo com o procedimento cirúrgico: ooforectomia bilateral (O) (n=20) e pseudo-cirurgia ("sham") (P) (n=20). Após 30 dias, os animais foram divididos em quatro subgrupos, de acordo com a administração de 0,1mg/kg de ácido zoledrônico (AZ) ou água destilada (AD): OAZ (n=10), OAD (n=10), PAZ (n=10) e PAD (n=10). Após 12 meses, os animais foram eutanasiados e suas tíbias analisadas. No estudo clínico foi considerado o peso dos animais; no estudo biomecânico foram realizados ensaios compressivos e na análise histomorfométrica foi determinada a área trabecular óssea. Resultados: Os grupos "O" tiveram aumento de peso significativamente maior que os grupos "P" (p=0,005). Os grupos OAZ e PAZ tiveram aumento, não significativo, de peso quando comparados aos grupos OAD (p=0,47) e PAD (p=0,68). Os grupos com ácido zoledrônico e com água destilada suportaram carga máxima, semelhante (p=0,2), no momento em que ocorreu fratura. Nos grupos com ácido zoledrônico verificou-se o aumento não significante da área trabecular óssea quando comparados aos grupos com água destilada (p=0,21). Houve correlação positiva entre a área trabecular e a carga máxima (p=0,04; r=0,95). Conclusão: O ácido zoledrônico não influiu significativamente no peso dos animais. Os resultados mostraram aumento, não significante, tanto da resistên-cia óssea diafisária tibial, como da área trabecular óssea. Descritores -

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“…5 It is defined as acoustic mechanical vibrations of high frequencies, which produce thermal and non-thermal 6 physiological effects, and, since its introduction as a therapeutic resource more than six decades ago, 7 has rapidly become of commonplace use within physiotherapy. Its beneficial effects have been demonstrated in the treatment of a wide variety of conditions, with divers objectives such as promoting the healing of skin ulcers, 8 stimulating neovascularization in ischemic tissues, 9 promoting the integration of full thickness skin grafts, 10 accelerating the consolidation of fractures and pseudarthroses 11 and the healing of tendons. 12 In fact, therapeutic ultrasound induces physiological tissue changes, such as fibroblast activation, collagen synthesis and the decrease of inflammatory cells, by acceleration of the cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

O ultrassom terapêutico na medula espinhal acelera a regeneração do nervo ciático de ratos

et al. 2011

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Objective: To study the effects of low intensity ultrasound irradiation applied on the spinal cord on the regeneration of the rat's sciatic nerve after a controlled crush injury, evaluating the functional results of the sciatic functional index as measured on the video recorded images of the foot sole. Methods: Eighteen rats were submitted to a controlled crush injury of the right sciatic nerve and divided into two groups according to the treatment: Group 1 (n=9), simulated irradiation; Group 2 (n=9), effective irradiation. Low-intensity ultrasound irradiation was started on the 7th postoperative day and applied daily for 6 weeks. Images of the animals´ foot sole were video recorded on a see-through treadmill type walking belt machine at weekly intervals until the 6th week of irradiation and the corresponding sciatic functional index (SFI) was measured with specific software. Results: The SFI during the first and last week of treatment was -59.12 and -12.55 in Group 1, -53.31 and -1.32 in Group 2, indicating a 79% and 97% improvement, respectively, but differences between groups were only significant (p<0.05) during the third week. Conclusion: The authors conclude that low intensity therapeutic ultrasound enhances nerve regeneration, with significance during the 3rd week of treatment. Level of Evidence: Level II, prospective comparative study.

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Ação do ultra-som de baixa intensidade em ossos de ratas osteopênicas.

Cited by 21 publications

References 40 publications

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Efeito do ácido zoledrônico em tíbias de ratas ooforectomizadas: estudo prospectivo e randomizado

O ultrassom terapêutico na medula espinhal acelera a regeneração do nervo ciático de ratos

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