Abuse in Childhood and Risk of Uterine Leiomyoma

Boynton-Jarrett, Renée; Rich‐Edwards, Janet W.; Jun, Hee-Jin; Hibert, Eileen N.; Wright, Rosalind J.

doi:10.1097/ede.0b013e3181ffb172

Cited by 51 publications

(22 citation statements)

References 64 publications

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“…There are no previous studies with which to compare our results, but our data are consistent with studies showing associations between UL and other psychosocial stressors, including abuse, 11,12 stress intensity, 9 and perceived racism. 10 Strengths of our study include the prospective design and validation of UL.…”

Section: Commentsupporting

confidence: 90%

“…8 A cross-sectional study found a higher prevalence of UL among women reporting more major life events and greater “stress intensity.” 9 In the Black Women’s Health Study (BWHS), a prospective cohort study, perceived racism was positively associated with UL diagnoses. 10 In agreement with a previous cohort study of white women, 11 the BWHS documented a positive association between child sexual abuse and UL diagnoses. 12 …”

Section: Introductionsupporting

confidence: 83%

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Depressive symptoms and risk of uterine leiomyomata

Wise¹,

Li²,

Palmer³

et al. 2015

American Journal of Obstetrics and Gynecology

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Objective Uterine leiomyomata (UL) are a major source of gynecologic morbidity and the primary indication for hysterectomy. Depression can cause dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which may affect the synthesis of reproductive hormones involved in UL pathogenesis. We assessed the association between depressive symptoms and UL among 15,963 premenopausal women. Study Design Data were derived from the Black Women’s Health Study, a prospective cohort study. In 1999 and 2005, the Center for Epidemiologic Studies Depression Scale (CES-D) was used to ascertain depressive symptoms. On biennial follow-up questionnaires from 1999 through 2011, women reported physician-diagnosed depression, antidepressant use, and UL diagnoses. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression. Results There were 4,722 incident UL cases diagnosed by ultrasound (n=3,793) or surgery (n=929) during 131,262 person-years of follow-up. Relative to baseline CES-D scores <16, IRRs were 1.05 (95% CI, 0.98–1.13) for CES-D scores 16–24 and 1.16 (95% CI, 1.06–1.27) for CES-D scores ≥25 (P-trend=0.001). IRRs for current and past physician-diagnosed depression relative to no depression were 1.15 (95% CI: 0.98, 1.34) and 1.25 (95% CI: 1.13, 1.39), respectively. Results persisted after further control for antidepressant use. IRRs for current and past use of antidepressants (any indication) relative to never use were 1.11 (95% CI: 0.97, 1.28) and 1.32 (95% CI: 1.14, 1.52), respectively. Conclusions In this cohort of black women, greater depressive symptoms were associated with UL, independent of antidepressant use, supporting the hypothesis that dysregulation of the HPA axis increases UL risk.

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Section: Commentsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 83%

Depressive symptoms and risk of uterine leiomyomata

Wise¹,

Li²,

Palmer³

et al. 2015

American Journal of Obstetrics and Gynecology

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“…As previously described, 27 we performed a factor analysis, using the maximum likelihood estimation method followed by the oblique (promax) rotation that yielded two factors which were consistent with our theoretically pre-determined latent constructs of physical and sexual abuse. Factor loadings were > 0.45 for all items on the assigned factor.…”

Section: Methodsmentioning

confidence: 91%

Childhood Abuse and Age at Menarche

Boynton-Jarrett

Wright

Putnam

et al. 2013

Journal of Adolescent Health

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121

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Purpose Physical and sexual abuse are prevalent social hazards. We sought to examine the association between childhood physical and sexual abuse and age at menarche. Methods Among 68,505 participants enrolled in the Nurses’ Health Study II we investigated the association between childhood physical abuse and sexual abuse on menarche prior to age 11 (early) or after age 15 (late) using multivariate logistic regression analysis, mutually adjusting for both types of abuse. Results Fifty-seven percent of respondents reported some form of physical or sexual abuse in childhood. We found a positive dose-response association between severity of sexual abuse in childhood and risk for early menarche. Compared to women who reported no childhood sexual abuse, the adjusted odds ratio [AOR] for early menarche was 1.20 (95% confidence interval [CI], 1.10, 1.37) for sexual touching and 1.49 (95% CI, 1.34, 1.66) for forced sexual activity. Only severe physical abuse predicted early menarche (AOR=1.22, 95% CI, 1.10–1.37). Childhood physical abuse had a dose-response association with late age at menarche: AOR 1.17 (95% CI, 1.04, 1.32) for mild, 1.20 (95% CI, 1.08, 1.33) for moderate, and 1.50 (95% CI, 1.27, 1.77) for severe physical abuse. Sexual abuse was not associated with late menarche. Conclusion Childhood abuse was very prevalent in this large cohort of U.S. women. Severity of childhood sexual abuse was associated with risk for early onset of menarche, and physical abuse was associated with both early and late onset menarche. Implications and Contribution The severity of childhood sexual abuse and severe physical abuse were associated with risk for accelerated menarche, while severity of childhood physical was associated with risk for delayed onset of menarche. The nature of the association between different forms of childhood adversities and reproductive lifespan may vary.

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“…In a cross-sectional study, a higher risk of UL was found with greater number of major life events and “stress intensity” [140]. The NHS II found a higher incidence of UL among women who experienced early-life abuse [141]; among women reporting an emotionally supportive relationship in childhood, the risk was lower, suggesting that social and emotional support may buffer the impact of stress on risk.…”

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

269

122

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Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few studies have identified opportunities for primary prevention of these neoplasms. Most established risk factors are not modifiable, including premenopausal age, African ancestry, age at menarche, and childbearing history. The main challenge in studying UL is that a large proportion of tumors are asymptomatic. Herein, we review the epidemiology of UL from published studies to date. We highlight the advantages of ultrasound screening studies and the ways in which their innovative methods have helped clarify the etiology of disease. We conclude with a discussion of promising new hypotheses.

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Abuse in Childhood and Risk of Uterine Leiomyoma

Cited by 51 publications

References 64 publications

Depressive symptoms and risk of uterine leiomyomata

Depressive symptoms and risk of uterine leiomyomata

Childhood Abuse and Age at Menarche

Epidemiology of Uterine Fibroids

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