Epidemiology of Uterine Fibroids

Wise, Lauren A.; Laughlin-Tommaso, Shannon K.

doi:10.1097/grf.0000000000000164

Cited by 269 publications

(183 citation statements)

References 223 publications

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“…14 A prospective cohort study was conducted by Wise LA et al, among 2146 women in US for a period of 4 years between 1997 to 2001. 14 This study showed that the women with BMI between 30.0-32.4 had highest risk of uterine fibroids. Risk was higher among parous women and weight gain since age 18 was positively associated with the risk, but only among parous women.…”

Section: Discussionmentioning

confidence: 68%

Association between uterine leiomyoma with body mass index and parity in the women of coastal Karnataka, India

Shetty

Pawaskar

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Fibroid is the commonest benign tumor of the uterus and also commonest benign solid tumor in females. Fibroids are found to be 2-3 times more prevalent in obese women, specially the one’s with central obesity and in those with BMI > or = 35. Epidemiologic data also shows pregnancy is associated with reduced risk of fibroids. So, the present study will be a cross-sectional study which will be undertaken to know the association of uterine leiomyoma with BMI and parity in the women of coastal Karnataka.Methods: An analytical cross-sectional study was performed among the 100 patients attending OPD at the department of obstetrics and gynecology, Karwar institute of medical sciences from June 2018 to August 2018. Women suspected to have fibroid based on their symptoms were made to undergo ultrasonography. Comparison was made between the parity, body mass index of the patient and the size of the uterine fibroid visualized.Results: Out of 100 women studied 63 were nulliparous and 37 women were multiparous. Incidence of fibroid is inversely proportional to parity. When BMI < 18 only 6 women had fibroid, when BMI > 25, 57 women had fibroids and between 18-25 group 37 women were diagnosed with fibroid.Conclusions: The fibroid showed directly proportional association with BMI. Greater the BMI, more was the risk of fibroids. The fibroid showed inversely proportional association with parity. Greater the parity of the women lesser was her chances of being at risk of having fibroid.

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Section: Discussionmentioning

confidence: 68%

Association between uterine leiomyoma with body mass index and parity in the women of coastal Karnataka, India

Shetty

Pawaskar

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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“…These tumors are often asymptomatic and their diagnosis can be the result of an incidental finding during a gynecological exam or ultrasound check. 3 From 20% to 50% of the women with UF experience heavy menstrual bleeding and pelvic pressure; other common symptoms include infertility, increased urinary frequency or incontinence, constipation, abdominal bloating, dyspareunia, and fatigue (due to anemia from heavy bleeding). 1 , 4 …”

Section: Introductionmentioning

confidence: 99%

Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women

Chiumente¹,

Rosa²,

Messori³

et al. 2017

CEOR

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Background and purposeEpidemiological studies on uterine fibroids (UFs) are mostly based on surveys or analyses of small samples of patients. In 50% of women, the quality of life is worsened by disease-related symptoms; furthermore, treatments imply a remarkable health care cost. The aim of this observational study was to analyze a large sample of Italian patients with UFs and to assess the epidemiology, the appropriateness of treatments, and the consumption of disease-related resources.MethodsData were collected through a data-linkage technique from five administrative databases. Women aged between 18 and 55 years and resident in three local health authorities (north–central–south Italy) were selected over the period from 1st January 2009 to 31st December 2015. The inclusion criteria were a surgical procedure with diagnosis of UFs or a pharmacological treatment with gonadotropin-releasing hormone (GnRH) analogs or ulipristal acetate. Besides the overall descriptive analysis, two comparisons were evaluated: surgery versus no surgery and treatment with GnRH analogs versus ulipristal acetate.ResultsA total of 5,665 women with UFs were selected from an overall population of 2,400,000 people. In the north, 73.6% of patients underwent surgery, as opposed to only 16.7% in the south; 70% of surgeries were hysterectomies. The average cost per patient was €3,249 (duration of follow-up = up to 7 years). The southern district had the highest number of drug prescriptions; in particular, 49% of patients took >10 packages of GnRH analogs.ConclusionThis study is the first on this topic conducted in Italy using a large sample size. The analysis of resource consumption revealed a high heterogeneity in the choice of drug treatments by gynecologists (especially in the south); in the north, marked variations were seen in the rates of surgery. The long-term use of GnRH was inappropriate.

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“…Uterine fibroids (UFs) are benign lesions and also the most common neoplasms of the female genital tract worldwide [1,2]. According to various data their prevalence may reach up to 70-80% in predisposed groups of women, but the frequency of the detection depends on selected diagnostic methods [3,4]. The risk factors for the UF's development include some modifiable and non-modifiable factors [3,5].…”

Section: Uterine Fibroids-overviewmentioning

confidence: 99%

The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside

Ciebiera

Włodarczyk

Zgliczyński

et al. 2020

IJMS

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Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up to 70–80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major reason of the overall deterioration of the quality of life. The mechanisms leading to UFs formation and growth still remain poorly understood. The transformation of smooth muscle cells of the uterus into abnormal, immortal cells, capable of clonal division, is thought to be a starting point of all pathways leading to UF formation. Micro-ribonucleic acids (miRNAs) are non-coding single-stranded RNAs about 22 nucleotides in length, that regulate gene expression. One of recent advances in this field is the comprehension of the role of miRNAs in tumorigenesis. Alterations in the levels of miRNAs are related to the formation and growth of several tumors which show a distinct miRNA signature. The aim of this review is to summarize the current data about the role of miRNAs in the pathophysiology of UFs. We also discuss future directions in the miRNA research area with an emphasis on novel diagnostic opportunities or patient-tailored therapies. In our opinion data concerning the regulation of miRNA and its gene targets in the UFs are still insufficient in comparison with gynecological malignancies. The potential translational use of miRNA and derived technologies in the clinical care is at the early phase and needs far more evidence. However, it is one of the main areas of interest for the future as the use of miRNAs in the diagnostics and treatment of UFs is a new and exciting opportunity.

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Epidemiology of Uterine Fibroids

Cited by 269 publications

References 223 publications

Association between uterine leiomyoma with body mass index and parity in the women of coastal Karnataka, India

Association between uterine leiomyoma with body mass index and parity in the women of coastal Karnataka, India

Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women

The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside

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