Absorption of anticancer drugs through bladder epithelium

Mishina, Teruo; Watanabe, Hiroki; Kobayashi, Tokuro; Maegawa, Mikio; Nakao, Masahiro; Nakagawa, Shuichi

doi:10.1016/0090-4295(86)90372-9

Cited by 51 publications

(10 citation statements)

References 3 publications

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“…When solubilized in water alone, the size of the resiniferatoxin molecule precludes intracellular penetration of urothelial cells and to reach C-fibers resiniferatoxin must pass through the intercellular channels (pores) associated with the junctional complex between the lateral cell membranes. 21 When in the region of the filamentous lamina propria, diffusion to receptor sites on C-fibers should be rapid. For capsaicin the situation is more complicated.…”

Section: Discussionmentioning

confidence: 99%

Intravesical Capsaicin Versus Resiniferatoxin In Patients With Detrusor Hyperreflexia: A Prospective Randomized Study

et al. 2002

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Purpose: Capsaicin and resiniferatoxin (Sigma Chemical Co., St. Louis, Missouri) administered intravesically are attractive options for treating detrusor hyperreflexia. Because the 2 agents differ in chemical structure and relative potency, possible differences in their clinical and urodynamic effects were investigated in this prospective comparative study.Materials and Methods: A group of 24 spinal cord injured patients with refractory detrusor hyperreflexia were randomly assigned to receive a single dose of 2 mM. capsaicin in 30 ml. ethanol plus 70 ml. 0.9% sodium chloride or 100 nM. resiniferatoxin in 100 ml. 0.9% sodium chloride. Dwell time was 40 minutes with urodynamic monitoring. Urodynamics were performed at baseline before treatment, and after followups of 30 and 60 days. The frequency of daily catheterizations, incontinence episodes and side effects was recorded.Results: There was no significant urodynamic or clinical improvement in the capsaicin arm at 30 and 60 days of followup. In the resiniferatoxin arm the mean uninhibited detrusor contraction threshold plus or minus standard deviation increased from 176 Ϯ 54 to 250 Ϯ 107 ml. at 30 days (p Ͻ0.05) and to 275 Ϯ 98 ml. at 60 days (p Ͻ0.01). Mean maximum bladder capacity increased from 196 Ϯ 75 to 365 Ϯ 113 ml. at 30 days (p Ͻ0.001) and to 357 Ϯ 101 ml. at 60 days (p Ͻ0.001). Daily catheterizations and incontinent episodes were significantly decreased at 30 and 60 days of followup. Autonomic dysreflexia, limb spasms, suprapubic discomfort and hematuria developed in most patients who received capsaicin but in none who received resiniferatoxin.Conclusions: Intravesical administration of resiniferatoxin is superior to that of capsaicin in terms of urodynamic results and clinical benefits in spinal cord injured patients and it does not cause the inflammatory side effects associated with capsaicin.

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Section: Discussionmentioning

confidence: 99%

Intravesical Capsaicin Versus Resiniferatoxin In Patients With Detrusor Hyperreflexia: A Prospective Randomized Study

et al. 2002

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“…The bladder's natural function as a reservoir for liquid waste enables it to be an ideal site for local drug application without systemic absorption. Mitomycin C (MMC), a 328-kD DNA alkylating agent, was found to be the best readily available agent based on lipophilicity, molecular weight, and pKa [18]. Further studies into MMC have attempted to optimize the local milieu for urothelial absorption.…”

Section: General Principlesmentioning

confidence: 98%

Optimal Treatment of Non-Muscle Invasive Urothelial Carcinoma Including Perioperative Management Revisited

2014

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Non-muscle invasive urothelial carcinoma is a heterogeneous disease that requires the practicing urologist to implement a variety of surgical and non-surgical treatment strategies. The disease course can range from recurrent low grade papillary disease to aggressive disease concerning for progression from initial presentation. Depending on the particular patient and goals of care, treatments similarly span the range from minimally invasive fulgurations to immediate radical cystectomy. For most patients some form of intravesical therapy will bridge the gap between transurethral resections (TUR) and radical surgery. Recent advances in the field continue to emphasize the importance of quality TUR and its strong impact on outcomes. In addition, continued research to optimize intravesical therapies has provided more information about how, when, and in whom these agents should be utilized to enhance their efficacy. This review covers the current state of NMIBC and the standards of care for the management of this disease.

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“…Fundamental experiments on the absorption through the bladder epithelium (Mishina et al 1986) suggested that the permeability of ADM was restricted within the mucosa and the lamina propria. In the present study, it was demonstrated clearly that ADM permeated deeply into the lamina propria or the inner layer of the muscle within 15 min of instillation and thereafter ADM was confined mostly to that region.…”

Section: Discussionmentioning

confidence: 99%

“…These data may agree with the conclusion stated above. Anticancer drugs permeated into the lamina propria were considered to cause both general and local side-effects (Mishina et al 1986). The fluorescence histological findings that orange fluorescent ADM was observed in the endothelial cells of the fluorescence in the rat bladder wall…”

Section: Discussionmentioning

confidence: 99%

Fluorescence microscopic study on absorption of adriamycin through the rat bladder epithelium.

Nakagawa

Kojima

Nakao

et al. 1987

Tohoku J. Exp. Med.

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Absorption of anticancer drugs through bladder epithelium

Cited by 51 publications

References 3 publications

Intravesical Capsaicin Versus Resiniferatoxin In Patients With Detrusor Hyperreflexia: A Prospective Randomized Study

Intravesical Capsaicin Versus Resiniferatoxin In Patients With Detrusor Hyperreflexia: A Prospective Randomized Study

Optimal Treatment of Non-Muscle Invasive Urothelial Carcinoma Including Perioperative Management Revisited

Fluorescence microscopic study on absorption of adriamycin through the rat bladder epithelium.

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