Fluorescence microscopic study on absorption of adriamycin through the rat bladder epithelium.

Nakagawa, Shuichi; Kojima, Munekado; Nakao, Masahiro; Watanabe, Hiroki

doi:10.1620/tjem.153.227

Cited by 5 publications

(1 citation statement)

References 5 publications

(5 reference statements)

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“…If this theory is accepted, verapamil HC1 is thought to be suitable to permeate the bladder epithelium into the submucosal or a much deeper region of the bladder wall, because intravesically administered adriamycin, which has similar characteristics to verapamil HCI in the three factors mentioned, showed a sufficient permeability into the inner layer of the muscle within 15 min after instillation (Nakagawa et al 1987). The present study revealed that verapamil HC1 administered intravesically interfered with the bladder function, particularly on MVP and RR.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravesically administered Verapamil HCl (Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats.

Ukimura

Kojima

Itoh

et al. 1992

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Effects of Intravesically administered Verapamil HCl (Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats.

Ukimura

Kojima

Itoh

et al. 1992

Tohoku J. Exp. Med.

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Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder

et al. 1992

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We examined the effect of dimethylsulfoxide (DMSO) on the absorption of a chemotherapeutic drug instilled into the bladder. Female Wistar rats with bladder tumors underwent intravesical instillation of normal saline (S group) or 50% DMSO (D group) prior to the administration of pirarubicin (tetrahydropyranyl-Adriamycin). The absorption of pirarubicin was estimated histologically by observing its fluorescence. In the S group, fluorescence of pirarubicin was observed only in the epithelial layer of normal or hyperplastic regions and in the cells of superficial layers of the tumor. In the D group fluorescence was observed in the entire bladder wall of normal or hyperplastic regions and extended to deeper regions of the tumors than in the S group. These findings indicate enhancement of the absorption of pirarubicin by pretreatment with DMSO.

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Effect of Urine pH on the Stability of Doxorubicin and its Recovery from Bladder Instillations

Ilett

Ong

Batty

et al. 1990

British Journal of Urology

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Doxorubicin (1 mg/ml) was shown to be stable when added to urine samples with a mean natural pH of 5.4 and in urine buffered to a mean pH of 4.6. However, at alkaline pH (mean = 8.1) there was a biphasic degradation of doxorubicin (mean t1/2 = 3.24 and 89 h respectively). The data indicate that buffering intravesical doxorubicin to pH 4.6 (acetate buffer) or pre-dosing of patients with ammonium chloride may minimise loss of active drug during the time for which the drug is retained in the bladder. Recovery of doxorubicin following 1 hour's retention in the bladder was similar (77%) for doses of 38/48 or 78 mg. It is suggested that a dose of 50 mg (1 mg/ml) is sufficient to ensure an adequate delivery of active drug to the bladder wall.

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Fluorescence microscopic study on absorption of adriamycin through the rat bladder epithelium.

Cited by 5 publications

References 5 publications

Effects of Intravesically administered Verapamil HCl (Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats.

Effects of Intravesically administered Verapamil HCl (Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats.

Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder

Effect of Urine pH on the Stability of Doxorubicin and its Recovery from Bladder Instillations

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