Absence of renin in kidneys of elasmobranchs and cyclostomes

Nishimura, Hiroko; Oguri, Mikio; Ogawa, Mitsuhiro; Sokabe, Hirofumi; Imai, Momoko

doi:10.1152/ajplegacy.1970.218.3.911

Cited by 57 publications

(11 citation statements)

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“…Thus, it is likely that the initial attempt to detect ANG activity in the lamprey was not successful because of the use of rat as an assay animal (Nishimura et al, 1970). In the eel, however, (Takei, 1987), indicating the coevolution of the ANG molecule and its receptor during vertebrate phylogeny.…”

Section: Discussionmentioning

confidence: 99%

Identification of Angiotensin I in a Cyclostome, Lampetra fluviatilis

Rankin¹,

Watanabe

Nakajima

et al. 2004

Zoological Science

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Section: Discussionmentioning

confidence: 99%

Identification of Angiotensin I in a Cyclostome, Lampetra fluviatilis

Rankin¹,

Watanabe

Nakajima

et al. 2004

Zoological Science

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“…The elasmobranch angiotensins are somewhat unusual and possess asparagine at position 1 and isoleucine at position 5, with a unique proline substitution at position 3 (Takei et al 1993). Prior to the recent isolation of homologous dogfish angiotensin, elasmobranchs were widely believed to lack a RAS (Nishimura et al 1970), so little information is available regarding the physiological role of ANG II in this vertebrate group.…”

Section: Introductionmentioning

confidence: 99%

Direct vasoconstrictor action of homologous angiotensin II on isolated arterial ring preparations in an elasmobranch fish

Hamano

Tierney²,

Ashida³

et al. 1998

Journal of Endocrinology

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Arterial rings were prepared from the branchial artery, coeliac artery and ventral aorta of the Japanese dogfish Triakis scyllia and used to determine arterial contraction in a myograph. Noradrenaline caused a dose-dependent contraction (10 9 -3 10 6 M) that was completely inhibited by pre-treatment with 10 7 M phentolamine. ]-ANG II is not mediated by the -adrenergic system and contractions of arterial rings by noradrenaline and elasmobranch ANG II are mediated by separate vascular receptors. The elasmobranch ANG II vascular receptor may have co-evolved with the unusual structure of this peptide.

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“…For decades, the RAS was believed to have first evolved in bony fishes and to be absent from both elasmobranchs and cyclostomes (Nishimura et al, 1970;Nishimura and Ogawa, 1973;Nishimura, 1985;Henderson et al, 1993). However, Ang I has now been isolated and sequenced in the elasmobranch Triakis scyllia (Takei et al, 1993) and more recently in two cyclostomes: the sea lamprey Petromyzon marinus and the river lamprey Lampetra fluviatilis .…”

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confidence: 99%

Activation of the newly discovered cyclostome renin–angiotensin system in the river lampreyLampetra fluviatilis

Brown

Cobb

Frankling

et al. 2005

Journal of Experimental Biology

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SUMMARY This study describes the first investigations of the physiological signals involved in activating the newly discovered cyclostome renin–angiotensin system (RAS) and its role in the river lamprey Lampetra fluviatilis. Experimental manipulation showed that volume depletion (removal of 40% blood volume) rapidly activated the RAS of lampreys acclimated to water at 576 mOsm kg–1 (21 p.p.t.), significantly increasing plasma angiotensin concentrations after 30 min and 60 min. In agreement with these results, a rapid change in environmental salinity (758 mOsm kg–1 to freshwater (FW) and FW to 605 mOsm kg–1), resulted in a rapid decrease and increase in plasma [angiotensin], respectively. Intraperitoneal(i.p.) injection of FW-acclimated river lampreys with 1% body mass by volume of nominally isosmotic saline (120 mmol l–1 NaCl; 233 mOsm kg–1) resulted in a significant decrease in the plasma angiotensin concentration within 15 min. In contrast, i.p. injection of hyperosmotic saline (4 mol l–1 NaCl) at 1% body mass by volume, which significantly increased plasma osmolality, had no significant effect on plasma [angiotensin], suggesting that volume/pressure receptors and osmoreceptors interact in regulating the lamprey RAS. These results indicate an important role for volume/pressor receptors, as in teleosts, but with an additional osmoreceptor mechanism, such that circulatory [angiotensin] is determined by interaction of volume/pressure and osmoreceptors and their relative sensitivities. The volume/pressure sensitivity is in keeping with the recent evidence of a vasoconstrictor action of homologous lamprey angiotensin and provides evidence that the fundamental role of the RAS in maintaining volume and pressure is an ancient function conserved over 500 million years of vertebrate evolution.

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Absence of renin in kidneys of elasmobranchs and cyclostomes

Cited by 57 publications

References 0 publications

Identification of Angiotensin I in a Cyclostome, Lampetra fluviatilis

Identification of Angiotensin I in a Cyclostome, Lampetra fluviatilis

Direct vasoconstrictor action of homologous angiotensin II on isolated arterial ring preparations in an elasmobranch fish

Activation of the newly discovered cyclostome renin–angiotensin system in the river lampreyLampetra fluviatilis

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