Absence of CD83-positive mature and activated dendritic cells at cancer nodules from patients with hepatocellular carcinoma: relevance to hepatocarcinogenesis

Chen, Shenren; Akbar, Sk. Md. Fazle; Tanimoto, K.; Ninomiya, T.; Iuchi, Hidehito; Michitaka, Kojiro; Horiike, Norio; Onji, Morikazu

doi:10.1016/s0304-3835(99)00312-2

Cited by 69 publications

(51 citation statements)

References 21 publications

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“…It is noteworthy that Chen et al 41 could not find CD83 ϩ dendritic cells in HCC nodules, suggesting that the immature phenotype of dendritic cell predominates in HCC. Some HCC cell lines secrete MIP3-␣, a potent chemoattractant for immature dendritic cells, and it has been reported that serum levels of MIP3-␣ are elevated in patients with HCC.…”

Section: Discussionmentioning

confidence: 99%

Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells

et al. 2005

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H epatocellular carcinoma (HCC), the fifth most common cancer worldwide with 564,000 new cases each year, is also the third most common cause of cancer-related death. 1 HCC arises most frequently in males with cirrhosis, which is most often a consequence of chronic hepatitis infection or alcohol abuse. 2 Recent reports from different countries suggest that the incidence of HCC is increasing, probably as a consequence of the increased prevalence of hepatitis C virus (HCV) infection, although increased alcohol consumption may be significant. 3 The only effective approaches for patients with HCC are resection or liver transplantation. Following transplantation, there is an 83% 4-year recurrence-free survival in highly selected patients (single tumor Ͻ5 cm in diameter or fewer than three tumors Ͻ3 cm in diameter). 4 However, the majority of patients do not meet such strict criteria or have other contraindications. Local therapies such as percutaneous ethanol injection, thermal ablation, and intra-arterial chemoembolization are less successful, 5 and less than 10% of patients with moderate disease (Okuda stage 2) survive for 3 years. 6 Immunological mechanisms are important in the surveillance of malignancy and control of tumor progression. Cytotoxic CD8 ϩ lymphocytes (CTLs) and natural killer cells are potential effector cells in the control of tumor growth, although both require CD4 ϩ T helper 1 immune responses for optimal function. 7 Tumor-infiltrating lym-

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Section: Discussionmentioning

confidence: 99%

Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells

et al. 2005

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“…Studies have previously shown that there is a numerical and functional defect in the peripheral DCs in HCC patients with hepatitis B and C virus infections, although it is unclear whether this defect is a cause or an effect [13,14] . On the other hand, there have been reports that have shown the frequency of activated CD83 + DCs in the peripheral circulation of HCC patients was comparable to patients with liver cirrhosis and normal healthy controls [15] . However, when compared to peripheral blood, activated DCs were present at a much lower frequency in the liver tissues of the other study groups.…”

Section: Dendritic Cellsmentioning

confidence: 99%

Immunology of hepatocellular carcinoma

Sachdeva

Chawla

Arora

2015

WJH

100

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Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells (e.g. , dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC.

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“…Many observations have suggested that DCs in tumors are functionally impaired [19][20][21][22][23][24] . In this study, we compared the functions of DCs generated from EC patients with those from healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

“…Colorization was performed by diaminobenzidine (DAB)-hydrogen peroxide as a chromogen. Immunohistochemical staining of CD83 The staining of CD83 was performed with some modifications, according to a previously described method [19] . Formalin-fixed, paraffinembedded specimens were washed three times in PBS and treated with pepsin (5 mg/mL in 0.01 mol/L HCl, Zhongshan, Beijing, China) for 20 min at 37 before staining for CD83.…”

Section: Flow Cytometric Analysismentioning

confidence: 99%

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Study on immune function of dendritic cells in patients with esophageal carcinoma

Chen¹,

Luo²,

Zhang³

et al. 2004

WJG

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AIM:To investigate the immune function of dendritic cells from both peripheral blood and operated tissues of esophageal carcinoma patients in order to find the relationship between the immune function of dendritic cells and the pathogenesis of esophageal carcinoma. METHODS:The expression of CD83, CD80, and CD86 on the surface of dendritic cells cultured from the peripheral blood of patients was detected compared with that from health donors using flow cytometry. The ability of dendritic cells to induce T lymphocyte proliferation was evaluated by a liquid scintillation counter. The expression of CD80, CD86, CD83, and S-100 proteins was assessed in esophageal carcinoma tissues using immunohistochemical method. RESULTS:Compared with those from healthy donors, dendirtic cells cultured from the peripheral blood of patients expressed lower CD80 and CD86. Furthermore, the ability of dendritic cells in patients to induce T lymphocyte proliferation was significantly lower than that of the control group. Compared with the control group, the positive expression ratio and frequencies of CD80, CD86, and S-100 in esophageal carcinoma tissues were significantly down regulated. The expression of CD83 was up-regulated in the pericancerous tissues, but no expression was found in the cancerous nodules. CONCLUSION:The impaired immune function and the decreased number of dendritic cells cause pathogenesis and progression of esophageal carcinoma.

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Absence of CD83-positive mature and activated dendritic cells at cancer nodules from patients with hepatocellular carcinoma: relevance to hepatocarcinogenesis

Cited by 69 publications

References 21 publications

Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells

Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells

Immunology of hepatocellular carcinoma

Study on immune function of dendritic cells in patients with esophageal carcinoma

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