Abnormal salivary cortisol levels in social phobic patients in response to acute psychological but not physical stress

Furlan, Patricia; DeMartinis, Nicholas; Schweizer, Edward E.; Rickels, Karl; Lucki, Irwin

doi:10.1016/s0006-3223(00)01126-4

Cited by 107 publications

(83 citation statements)

References 14 publications

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“…Therefore, we measured the area under the curve (AUC) of the salivary cortisol level, calculated as the net area under the stress-response curve (all six samples, see Fig. 1), with reference to the baseline (first sample) by using trapezoidal integration (26).…”

Section: Methodsmentioning

confidence: 99%

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

Wang

Rao

Wetmore

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

460

379

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Despite the prevalence of stress in everyday life and its impact on happiness, health, and cognition, little is known about the neural substrate of the experience of everyday stress in humans. We use a quantitative and noninvasive neuroimaging technique, arterial spin-labeling perfusion MRI, to measure cerebral blood flow (CBF) changes associated with mild to moderate stress induced by a mental arithmetic task with performance monitoring. Elicitation of stress was verified by self-report of stress and emotional state and measures of heart rate and salivary-cortisol level. The change in CBF induced by the stress task was positively correlated with subjective stress rating in the ventral right prefrontal cortex (RPFC) and left insula͞putamen area. The ventral RPFC along with right insula͞putamen and anterior cingulate showed sustained activation after task completion in subjects reporting a high stress level during arithmetic tasks. Additionally, variations of baseline CBF in the ventral RPFC and right orbitofrontal cortex were found to correlate with changes in salivary-cortisol level and heart rate caused by undergoing stress tasks. We further demonstrated that the observed right prefrontal activation could not be attributed to increased cognitive demand accompanying stress tasks and extended beyond neural pathways associated with negative emotions. Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.anterior cingulate cortex ͉ arterial spin labeling ͉ right prefrontal cortex

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Section: Methodsmentioning

confidence: 99%

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

Wang

Rao

Wetmore

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

460

379

View full text Add to dashboard Cite

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“…This can be studied empirically using standardized social stress protocols measuring neurohormonal changes. The literature to date examining the cortisol stress response (CSR) following a social challenge in SAD has reported mixed results (Beaton et al, 2006;Condren et al, 2002;Furlan et al, 2001;Levin, 1993;Martel et al, 1999;Roelofs et al, 2009;Shirotsuki et al, 2009;van West et al, 2008;Yoon, 2012). One possible explanation for this inconsistency is that moderating factors such as childhood trauma (CT) have a greater influence on social stress responses and/or overall cortisol secretion than does the condition, itself.…”

Section: Introductionmentioning

confidence: 99%

The cortisol response to social stress in social anxiety disorder

Vaccarino

Levitan

Ravindran

2015

Asian Journal of Psychiatry

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“…Findings of HPA axis dysregulation in patients with primary anxiety disorders are generally less robust than in those with major depression (Arborelius et al, 1999;Young et al, 2004). However, HPA axis hyperactivity has been documented in studies of social phobia (Furlan et al, 2001), panic disorder (Abelson and Curtis, 1996;Coryell et al, 1991;Roy-Byrne et al, 1986;Schreiber et al, 1996;Wedekind et al, 2000), generalized anxiety (Roy-Byrne et al, 1986), obsessive-compulsive disorder (Altemus et al, 1992), and mixed anxietydepressive disorder (Kara et al, 2000). In contrast, patients with post-traumatic stress disorder show evidence of decreased basal cortisol levels and increased negative feedback regulation of the HPA axis as compared to normal controls (Yehuda, 1997).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Cortisol Responses to Stress and Personality

Oswald

Zandi

Nestadt

et al. 2006

Neuropsychopharmacol

227

141

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Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. The purpose of this study was to examine associations between personality traits and cortisol responses to stress using the Revised NEO Personality Inventory five-factor model of personality. In total, 68 healthy adults, aged 18-30 years, completed the personality assessment and underwent a laboratory psychological stress test that consisted of a 5 min speech and 5-min of mental arithmetic. Findings showed that in the sample as a whole, less Openness was associated with lower cortisol responses to the challenge. Cortisol responses also corresponded to certain personality dimensions in a gender-specific manner. Blunted cortisol responses were associated with higher Neuroticism in women and with lower Extraversion in men. These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress.

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Abnormal salivary cortisol levels in social phobic patients in response to acute psychological but not physical stress

Cited by 107 publications

References 14 publications

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

The cortisol response to social stress in social anxiety disorder

Relationship between Cortisol Responses to Stress and Personality

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