Abnormal leukocyte motility in patients with early‐onset periodontitis

Page, Roy C.; Sims, Tom J.; Geissler, F; and, L. C. Altman; Baab, David A.

doi:10.1111/j.1600-0765.1984.tb01321.x

Cited by 41 publications

(32 citation statements)

References 5 publications

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“…In different forms of periodontal disease (prepubertal periodontitis, juvenile periodontitis, rapidly progressive periodontitis), impaired neutrophil chemotaxis has been well demonstrated previously [29,32,33]. Severe periodontal destruction at an early age together with comparable alveolar bone loss and various degrees of impairment of the host response, are prominent features of both DS and juvenile periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

Yavuzyilmaz

Ersoy

Sanal

et al. 1993

The Journal of Nihon University School of Dentistry

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Section: Introductionmentioning

confidence: 99%

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

Yavuzyilmaz

Ersoy

Sanal

et al. 1993

The Journal of Nihon University School of Dentistry

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“…(Fenesy, 1998). Epidemiological evidence indicates the existence of high risk groups and suggests that a variety of disease markets (risk factors) may predispose individuals to periodontitis Johnson et al (1988) Some forms of increased disease susceptibility or intrinsic defects may be involved in patients with EOP; for example, neutrophil dysfunction Van Dyke et al (1985), abnormal lymphocyte subsets Kinane et al 1989), and aberrant cytokine production Page et al (1985). Furthermore, a high prevalence of EOP patients in certain families and linkage with specific human leukocyte antigen (HLA) phenotypes have suggested that genetic factors may be involved in some cases and "Common risk factors" have been pointed out in these families.…”

Section: General Blood Examinationmentioning

confidence: 99%

“…The initiation and progression of periodontitis do not always occur in the same manner, because the host defensive mechanism varies among patients and race (Page et al 1985;Genco et al 1986, Genco, 1992; hence this study was designed to evaluate the numerical value of the defense cells in juvenile and non-juvenile periodontitis patients compare with the expected normal values in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Hematological values in juvienile periodontitis patients in Ibadan, Nigeria

Dosumu¹,

Asani²,

Akande³

et al. 2010

African Journal of Biomedical Research

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“…It has been known for many years that periodontal disease in prepubertal children is associated with defects in neutrophil function (Page et al, 1985). With a general neutrophil defect, for example in the chemotactic response, or in cyclic neutropenia, periodontal disease may occur in association with increased occurrence of otitis media and other repeated infections (reviewed by Hart and Kornman, 2000).…”

Section: Neutrophil Defects and Defects In Expression Of α-Defensins mentioning

confidence: 99%

Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease

2005

Current Issues in Molecular Biology

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The oral cavity is a unique environment in which antimicrobial peptides play a key role in maintaining health and may have future therapeutic applications. Present evidence suggests that α-defensins, β-defensins, LL-37, histatin, and other antimicrobial peptides and proteins have distinct but overlapping roles in maintaining oral health and preventing bacterial, fungal, and viral adherence and infection. The expression of the inducible hBD-2 in normal oral epithelium, in contrast to other epithelia, and the apparent differential signaling in response to commensal and pathogenic organisms, provides new insights into innate immunity in this body site. Commensal bacteria are excellent inducers of hBD-2 in oral epithelial cells, suggesting that the commensal bacterial community acts in a manner to benefit the overall innate immune readiness of oral epithelia. This may have major significance for understanding host defense in the complex oral environment. The oral environmentThe oral cavity is a unique environment. Oral mucosa is a critical protective interface between external and internal environments and must serve as a barrier to the myriad microbial species present in this warm, moist environment. The oral cavity is the only area of the body in which hard tissues break through the epithelial surface. The periodontal epithelium surrounding the tooth is specialized to form an attachment and seal around each tooth. This unique function imparts special challenges to the tissue and leads to certain vulnerabilities associated with periodontal disease, especially in view of the continual exposure to the bacterial biofilm (dental plaque) that forms on the tooth surface at the junction of the soft tissue. Thus, this anatomical region is one where there is a significant risk of bacterially induced infection and inflammation.Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment. These include several salivary antimicrobial peptides, the β-defensins expressed in the epithelium, the α-defensins expressed in neutrophils, and the cathelicidin, LL-37, expressed in both epithelium and neutrophils. These peptides are part of the host innate immune response in this environment. Epithelia, polymorphonuclear leukocytes (neutrophils), and saliva all contribute to the maintaining the health of the oral cavity in overlapping but independent ways. This review will focus on the human oral cavity and include 1) the expression and function of antimicrobial peptides in the oral cavity in the context of innate immune responses, 2) regulation of β-defensins which has led to advances in our understanding of oral epithelial innate immunity, and 3) functional efficacy against oral microbes when it is known. Epithelial antimicrobial peptidesHistorically, the oral epithelium has been considered mainly as a passive covering that becomes damaged and ulcerated in disease. This view has changed dramatically and the epithelial compartment is now seen as providing both...

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Abnormal leukocyte motility in patients with early‐onset periodontitis

Cited by 41 publications

References 5 publications

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

Hematological values in juvienile periodontitis patients in Ibadan, Nigeria

Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease

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