Abnormal development of intrinsic innervation in murine embryos with anorectal malformations

Kubota, Yoshihiro; Cho, Hirotomi; Umeda, Tomoko; Abe, Hajime; Kurumi, Yoshimasa; Tani, Toru

doi:10.1007/s00383-011-3017-y

Cited by 3 publications

(1 citation statement)

References 15 publications

(18 reference statements)

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“…The etiology of URSM has been linked to defects in mesodermal proliferation in early embryogenesis [ 7 ]. Kubota et al [ 15 ] investigated cell proliferation and apoptosis in murine embryos that develop anorectal malformations secondary to overdose administration of long acting vitamin A analogues. Results of the study demonstrated defective cell proliferation and cell apoptosis in the cloacal membrane and dorsocaudal region on day 11 with lack of apoptosis in the anal orifice on day 12 suggesting the severity of the presentation is related to the age of the fetus when the developmental defect takes place.…”

Section: Discussionmentioning

confidence: 99%

Prune Belly Syndrome with Overlapping Presentation of Partial Urorectal Septum Malformation Sequence in a Female Newborn with Absent Perineal Openings

Farooqui

Alaqeel

Zayeni

2014

Case Reports in Surgery

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Prune belly syndrome (PBS) is a rare congenital anomaly characterized in males by a triad of anomalous genitourinary tract, deficient development of abdominal wall muscles, and bilateral cryptorchidism. Although similar anomalies have been reported in females, by definition they do not full fill the classical triad. Urorectal septum malformation sequence (URSM) is a lethal condition characterized by presence of ambiguous genitalia, absent perineal openings (urogenital and anal), and lumbosacral abnormalities. In this original case report, the authors discuss the presentation and management of what would be analogous to a Woodhouse category 1 PBS in a female newborn associated with an overlapping presentation of URSM.

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Section: Discussionmentioning

confidence: 99%

Prune Belly Syndrome with Overlapping Presentation of Partial Urorectal Septum Malformation Sequence in a Female Newborn with Absent Perineal Openings

Farooqui

Alaqeel

Zayeni

2014

Case Reports in Surgery

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Abnormal serum vitamin A levels and retinoic acid receptor α expression patterns in children with anorectal malformation

Wang

et al. 2019

Pediatr Surg Int

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Pathology of the enteral nervous system in children with anorectal malformations

Pimenova

2022

Russian Journal of Pediatric Surgery

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Introduction. The review describes a pathology of the enteric nervous system (ENS) in patients with anorectal malformations (ARM). Functional gastrointestinal disorders in children with APM after anorectoplasty (bowel impaction, constipation and fecal incontinence) is an actual problem in pediatric surgery.Materials. Literature searches was done in Scopus, PubMed, Google Scolar and eLibrary databases.Results. Reasons of unsatisfactory outcomes after the treatment are various: underdevelopment of pelvic floor muscles, low sacral ratio, redo procedures. In recent years, a certain attention has been paid to the pathology of enteric nervous system in the structure of ARM pathologies, since the intrauterine migration of neuroblasts and formation of the intestinal neuronal network are inextricably linked with the hindgut anlage. At the same time, literature on ENS state in children with anorectal transformations is not numerous and scattered. Impairments in ENS development in patients with ARM, by different authors, ranges from 3.5 to 94%. By findings of multicenter trials, the incidence of true agangliosis (Hirschsprung’s disease) in children with ARM is low (up to 3.4%).Conclusion. ARM is a group of congenital malformations of the anorectal region. The quality of life of such patients often worsens after surgery due to functional disorders, such as incomplete bowel movements, constipation and fecal incontinence. Further researches are needed to identify changes in ENS in patients with anorectal malformations in order to correct management tactics and improve their quality of life after surgery.

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Abnormal development of intrinsic innervation in murine embryos with anorectal malformations

Cited by 3 publications

References 15 publications

Prune Belly Syndrome with Overlapping Presentation of Partial Urorectal Septum Malformation Sequence in a Female Newborn with Absent Perineal Openings

Prune Belly Syndrome with Overlapping Presentation of Partial Urorectal Septum Malformation Sequence in a Female Newborn with Absent Perineal Openings

Abnormal serum vitamin A levels and retinoic acid receptor α expression patterns in children with anorectal malformation

Pathology of the enteral nervous system in children with anorectal malformations

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