Zinner syndrome is a rare male genitourinary tract disorder associated with seminal vesicle cysts and ipsilateral renal agenesis. Clinical presentation often involves symptoms of the genitourinary tract. We present a case report of a young Saudi male, presenting with nonspecific symptoms of fatigue and malaise. Ultrasound visualized a massive seminal vesicle cyst associated with ipsilateral renal agenesis. The cyst was managed using a laparoscopic technique without any immediate complications and an uneventful postoperative period.
Prevotella is a common gram-negative anaerobic rod that is frequently associated with female genitourinary tract infections, pelvic inflammatory disease, aspiration pneumonia, lung abscess and pleural empyema. Osteomyelitis in association with septic arthritis is rare with only a handful of cases reported worldwide. In this case study, we report a patient who presented with a clinical picture of septic arthritis complicated by the presence of a sinus tract at the site of a previous arthroscopic surgery. Initial sinus pus cultures demonstrated Streptococcus agalactiae, which were confirmed with intra-operative joint fluid cultures. After a brief period of clinical improvement following arthrotomy, a sudden clinical deterioration prompted re-cultures demonstrating heavy growth of Provetella bivia. Repeat MRI demonstrated new signs of osseous involvement. The patient was managed with a redo arthrotomy, extensive debridement of osteomyelitic tissue, washout and an extended antibiotic therapy regimen. This association is first of its kind in Saudi Arabia.
Prune belly syndrome (PBS) is a rare congenital anomaly characterized in males by a triad of anomalous genitourinary tract, deficient development of abdominal wall muscles, and bilateral cryptorchidism. Although similar anomalies have been reported in females, by definition they do not full fill the classical triad. Urorectal septum malformation sequence (URSM) is a lethal condition characterized by presence of ambiguous genitalia, absent perineal openings (urogenital and anal), and lumbosacral abnormalities. In this original case report, the authors discuss the presentation and management of what would be analogous to a Woodhouse category 1 PBS in a female newborn associated with an overlapping presentation of URSM.
Striatin is a scaffold protein that associates with caveolin and calmodulin; key regulators of excitation‐contraction coupling in the heart. The aim of the present study was to probe for a potential role for striatin in regulating calcium homeostasis in cardiomyocytes. Our findings indicate that striatin is expressed in rat hearts (cardiomyocytes enriched fraction) with a higher expression level in neonates vs adults. Protein‐protein interaction assays revealed that, in the heart, striatin associates with calmodulin as well as caveolin‐1 and caveolin‐3 (muscle specific isoform). It was notable that the interaction between striatin and calmodulin was calcium sensitive: while calcium chloride (2 mM) showed robust pulldown of striatin with calmodulin, the calcium chelator EGTA (1 mM) attenuated this interaction. Moreover, KCl‐induced intracellular calcium [Ca2+]i increase was sustained in cardiomyocytes overexpressing striatin (adenoviral delivery) while [Ca2+]i returned to near basal levels in control cardiomyocytes (non‐target adenovirus). Collectively, our data indicate that striatin is expressed in cardiomyocytes and that it may play a role in maintaining [Ca2+]i homeostasis. This suggests that striatin may be involved in modulating cardiac excitation‐contraction coupling and emerges as a novel target for therapeutic strategies in cardiac diseases.
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