Massive seminal vesicle cyst with ipsilateral renal agenesis – Zinner syndrome in a Saudi patient

Farooqui, Azhar; AlDhahir, Loay; Mahfooz, Ali Bin

doi:10.4103/ua.ua_17_18

Cited by 15 publications

(16 citation statements)

References 10 publications

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“…Disturbance in any of these inductive events during this period of embryogenesis such as mutation of metanephric blastema, or disruption of retinoic acid signaling, causes inhibition of ureteric bud growth with failure of fusion of the Ureteric bud with the metanephric blastema and renal agenesis. 11 For this rare anomaly several optional treatments are available. Existence of bothersome symptoms is a significant factor that can affect the treatment options and most investigators recommend treatment only for symptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Zinner Syndrome – A Rare Congenital Malformation

Sunkara¹,

Kumar²,

Rao³

et al. 2020

IJOPP

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Section: Discussionmentioning

confidence: 99%

A Case Report on Zinner Syndrome – A Rare Congenital Malformation

Sunkara¹,

Kumar²,

Rao³

et al. 2020

IJOPP

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“…Zinner syndrome is one of the rarest congenital anomalies of the urogenital tract and is usually discovered and diagnosed in the 2nd-4th decade of life [3]. The frequency of this condition is reported to be 0.0046% according to Farooqui et al [4]. Patients with this syndrome are usually asymptomatic but they can present with dysuria, frequency, perineal pain, or epididymitis [3].…”

Section: Discussionmentioning

confidence: 99%

The Association of Renal Agenesis and Ipsilateral Seminal Vesicle Cyst: Zinner Syndrome Case Report

AlArifi

Al-Gahwary

Gomha

2019

Case Reports in Urology

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Introduction. Zinner syndrome is a rare congenital malformation characterized by the association of an ipsilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction. This case is one of the first to be reported in the Kingdom of Saudi Arabia. Case Presentation. A 20-year-old Saudi male patient presented complaining of chronic left groin pain radiating to the left testis and the medial aspect of the left thigh for the last 6 years. Patient is also complaining of painful ejaculation with no history of lower urinary tract symptoms, hematuria, or trauma. Physical examination was unremarkable. Ultrasound (US) report from the referring hospital mentioned that there is a left pelvic mass. Computed tomography (CT) and magnetic resonance imaging (MRI) showed diffuse distension of left seminal vesicle (9 X 7 cm) cyst with ipsilateral left renal agenesis which corresponds to Zinner syndrome. Left seminal vesicle cyst excision through a low midline incision was done. The patient was asymptomatic during his follow-up in our clinic with disappearance of the pain. Conclusion. The combination of a good clinical history and radiological assays aided in making the diagnosis. Surgical intervention is the mainstay in the management plan in symptomatic patients.

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“…ZS can be considered a variant of the Wolffian duct anomalies, with a classic triad of seminal vesicle cyst, ipsilateral renal agenesis, and male infertility due to ejaculatory duct obstruction (EDO). The prevalence of Sperm retrieval by conventional testicular sperm extraction for assisted reproduction in patients with Zinner syndrome cystic lesions in the pelvis with ipsilateral renal agenesis or dysplasia has been reported to be as high as 0.0046% [2]. Usually, this condition is also associated with other urogenital findings such as ureterocele, hypospadias, or abnormalities of the testes, epididymis, or adrenal glands [3,4].…”

Section: Introductionmentioning

confidence: 99%

Sperm retrieval by conventional testicular sperm extraction for assisted reproduction in patients with Zinner syndrome

Cito

Lepri

Giachini

et al. 2021

Clin Exp Reprod Med

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We present data from three Caucasian men with Zinner syndrome who attended our center for the treatment of primary couple’s infertility. Each patient was scheduled for multiple conventional testicular sperm extraction (cTESE) and cryopreservation. The mean duration of infertility was 243 months. Sperm analysis confirmed absolute azoospermia. In patient 1, imaging revealed right and left testis volumes of 24 mL and 23 mL, respectively; dilatation of the right caput epididymis, corpus, and cauda; left seminal vesicle agenesis; severe right seminal vesicle hypotrophy; right renal agenesis; and left nephroptosis. The patient’s levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (TT) were 3.2 IU/L, 5.2 IU/L, and 22.3 nmol/L, respectively. Patient 2 exhibited right and left testis volumes of 18 mL and 16 mL, respectively; a left seminal vesicle cyst of 3228 mm; ipsilateral kidney absence; and right seminal vesicle agenesis. The patient’s levels of FSH, LH, and TT were 2.8 IU/L, 4.2 IU/L, and 14.3 nmol/L, respectively. In patient 3, ultrasound showed a testicular volume of 10 mL bilaterally, a 6546 mm left seminal vesicle cyst, right seminal vesicle enlargement, and left kidney agenesis. The patient’s levels of FSH, LH, and TT were 32.0 IU/L, 16.3 IU/L, and 9.0 nmol/L, respectively. Sperm retrieval via cTESE was successful in all patients. It may be advisable to perform cTESE to obtain fresh sperm on the day of oocyte retrieval. Sperm cryopreservation should be avoided, since thawing could further compromise the sperm quality.

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Massive seminal vesicle cyst with ipsilateral renal agenesis – Zinner syndrome in a Saudi patient

Cited by 15 publications

References 10 publications

A Case Report on Zinner Syndrome – A Rare Congenital Malformation

A Case Report on Zinner Syndrome – A Rare Congenital Malformation

The Association of Renal Agenesis and Ipsilateral Seminal Vesicle Cyst: Zinner Syndrome Case Report

Sperm retrieval by conventional testicular sperm extraction for assisted reproduction in patients with Zinner syndrome

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