Abnormal serum vitamin A levels and retinoic acid receptor α expression patterns in children with anorectal malformation

Wang, Zhili; Wang, Quan; Gu, Chengchao; Zhang, Jingjie; Wang, Yi

doi:10.1007/s00383-019-04495-0

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Teratogenic drugs, such as ethylene thiourea and adriamycin, induce ARMs in rats. We have previously reported abnormal serum vitamin A levels and retinoic acid receptor α (RARα) expression patterns in children with ARMs (Z. Wang, Wang, Gu, Zhang, & Wang, 2019). Thus, we used ATRA to induce ARMs in rats in this study.…”

Section: Discussionmentioning

confidence: 99%

Folic acid rescues all‐trans retinoic acid‐induced anorectal malformations in rats

Bi³

et al. 2020

Birth Defects Research

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Background: To investigate whether folic acid (FA) can rescue anorectal malformations (ARMs) induced by all-trans retinoic acid (ATRA) in rats. Methods: Pregnant Sprague-Dawley rats were randomly divided into three groups. In the model group, rats were administered ATRA (110 mg/kg) by gavage on the 10th day of gestation (E10.5). Rats in the rescue group were administered FA (40 mg/kg) by gavage 0.5 and 12 hr after treatment with ATRA. All fetuses were harvested on E20.5 using cesarean section and examined for ARMs. We recorded the weight, body length, tail length, and associated malformations of all the embryos. Hematoxylin and eosin staining was used to analyze the histopathology of the fetuses. Results: Control rats did not show any abnormalities. ARMs, tail deformities (less than half of normal length), and neural tube defects were found in 97.98% (97/99), 92.93% (92/99), and 32.32% (32/99) of the rats in the model group, respectively. The incidence of ARMs and tail deformities were 48.57% (51/105) and 35.24% (37/105), respectively, in the rescue rats; no neural tube defects were observed in these rats. The weight, body length, and tail length of the fetal rats in the rescue group were more than those in the model group, but less than those in the control group. Conclusion: Taken together, FA rescued ARMs induced by ATRA in rats. Thus, FA may reduce the incidence of associated malformations and improve the growth and development of fetal rats.

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Section: Discussionmentioning

confidence: 99%

Folic acid rescues all‐trans retinoic acid‐induced anorectal malformations in rats

Bi³

et al. 2020

Birth Defects Research

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“…It was recently shown that the serum concentration of vitamin A in human ARM neonates was lower than that in control neonate [58]. These data and the fact that impaired RAR signalling pathways in rodents cause anorectal agenesis strongly suggest that maternal VAD, which remains a major public health issue in developing countries such as India, increases the risk of ARM in humans.…”

Section: Rar Signalling and Human Armmentioning

confidence: 99%

Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM

et al. 2021

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Anorectal malformations (ARMs) are relatively common congenital abnormalities, but their pathogenesis is poorly understood. Previous gene knockout studies indicated that the signalling pathway mediated by the retinoic acid receptors (RAR) is instrumental to the formation of the anorectal canal and of various urogenital structures. Here, we show that simultaneous ablation of the three RARs in the mouse embryo results in a spectrum of malformations of the pelvic organs in which anorectal and urinary bladder ageneses are consistently associated. We found that these ageneses could be accounted for by defects in the processes of growth and migration of the cloaca, the embryonic structure from which the anorectal canal and urinary bladder originate. We further show that these defects are preceded by a failure of the lateral shift of the umbilical arteries and propose vascular abnormalities as a possible cause of ARM. Through the comparisons of these phenotypes with those of other mutant mice and of human patients, we would like to suggest that morphological data may provide a solid base to test molecular as well as clinical hypotheses.

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“…It has been previously determined that environmental factors such as drug use in pregnancy, smoking, maternal diabetes mellitus, and retinoic acid embryopathy can cause ARM (6,7).…”

Section: Introductionmentioning

confidence: 99%

Molecular karyotyping in anorectal malformations: Could DGCR6 gene haploinsufficiency cause anal atresia in 22q11 deletion syndrome?

Cubuk¹

2021

Erciyes Med J

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Abnormal serum vitamin A levels and retinoic acid receptor α expression patterns in children with anorectal malformation

Cited by 5 publications

References 27 publications

Folic acid rescues all‐trans retinoic acid‐induced anorectal malformations in rats

Folic acid rescues all‐trans retinoic acid‐induced anorectal malformations in rats

Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM

Molecular karyotyping in anorectal malformations: Could DGCR6 gene haploinsufficiency cause anal atresia in 22q11 deletion syndrome?

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