Abdominal obesity and risk of CVD: a dose–response meta-analysis of thirty-one prospective studies

Xue, Ran; Li, Qianwen; Geng, Yaping; Wang, Hao; Wang, Fudi; Zhang, Shenshen

doi:10.1017/s0007114521000064

Cited by 44 publications

(26 citation statements)

References 58 publications

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“…Central obesity, with the adipose tissue predominantly concentrated around the viscera, is considered to have an increased unfavorable effect on cardiovascular risk [56,57]. A recent meta-analysis of prospective studies evaluating the link between abdominal obesity and cardiovascular risk has shown a strong association between the parameters describing central obesity (waist circumference, waist:hip ratio, and waist:height ratio) and cardiovascular diseases (including ischemic heart disease, cerebrovascular disease) [58]. The deleterious effect of visceral adipose surplus appears to manifest itself even in otherwise normal-weight individuals (according to BMI values) which show evidence of excess abdominal adiposity (measured by waist circumference for example) [59].…”

Section: Central Obesity and Metabolically Healthy Obesitymentioning

confidence: 99%

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

et al. 2021

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The past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obesity. This is a particularly concerning aspect when considering the well-established link between cardiovascular disease and obesity, and the fact that childhood obesity frequently leads to adult obesity. Moreover, most obese adults have a history of excess weight starting in childhood. In addition, given the cumulative character of both time and severity of exposure to obesity as a risk factor for associated diseases, the repercussions of obesity prevalence and related morbidity could be exponential in time. The purpose of this review is to outline key aspects regarding the current knowledge on childhood and adolescent obesity as a cardiometabolic risk factor, as well as the most common etiological pathways involved in the development of weight excess and associated cardiovascular and metabolic diseases.

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Section: Central Obesity and Metabolically Healthy Obesitymentioning

confidence: 99%

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

et al. 2021

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“…Estimation of the risk for metabolic disease and monitoring of conditions had been done so far, using the level of biochemical parameters, triglyceride, cholesterol, high-density lipoprotein and fasting serum glucose, and nonbiochemical, BMI and waist circumference, that also have rules in the risk assessment for cardiovascular diseases (especially central obesity) [21].…”

Section: Introductionmentioning

confidence: 99%

Irisin Level in Salah Adin’s Insulin Resistance Syndrome Patients in View of Global Controversy

Salih¹,

Zbaar²,

Zakari³

2022

PJMHS

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Background: Metabolic syndrome (high blood pressure, hyperglycemia, dyslipidemia, and obesity) is now an international health problem that impacts about 20 per cent to 25 per cent of the total population and can be worsened in the developing world, particularly in the Middle East, which is roughly two out of every five Iraqis. The metabolic syndrome has a direct link to many life-threatening diseases, such as cardiovascular disease, early onset of some cancers, such as colorectal cancer, Chronic liver illnesses, polycystic ovarian syndrome, and others. Methodology: A case-control study on a total of ninety volunteers (46 males and 44 females), comprising sixty metabolic syndrome patients (25 males and 35 females), defined in terms of international diabetic federation criteria, and thirty controls, is to be conducted at Salah Alden general hospital. Adults men and women aged (24-to 65) years who attended Salah Alden's main hospital outpatient clinics in Tikrit\Iraq, from October 2021 to March 2022 were included in the research. The levels (Irisin, and Insulin) in all research groups and controls are evaluated using an Enzyme-Linked Immune-sorbent Assay. Results: Irisin level was significantly higher among controls with a mean of (6.84ng/ml), compared to metabolic syndrome patient mean (5.71 ng/ml), and significantly negatively correlated to triglycerides level, and non-significantly negatively correlated with (systolic blood pressure, fasting serum glucose, and waist circumference) and non-significantly positively correlated to high-density lipoprotein level. Irisin levels were significantly different among treatment-based groups with the highest mean level among the treatment-free group (6.8450ng/ml±1.96052), followed by the antihypertensives taking group (5.3340ng/ml±2.99273), and the lowest mean level was recorded among diabetics (4.8916ng/ml±2.81952). Conclusion: With the exception of HDL, a high level of Asprosin and a low level of Irisin are strongly linked to metabolic syndrome and its components. Irisin levels differ amongst metabolic syndrome patients with various therapy groups. Keywords: Irisin, metabolic syndrome, Insulin Resistance.

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“…For example, sex- and age-specific cut-offs ( 18 , 19 ) complicate the use of BMI to define obesity in practice, and BMI does not accurately discriminate body fat distribution ( 20 ). In contrast, WC and WHtR are markers of abdominal adiposity that are more closely linked with metabolic disturbances ( 21 ), and more strongly associated with CVD outcomes ( 22 ) and all-cause mortality ( 23 ). Sex- and age-specific cut-offs of WC are also required to define central obesity, whereas WHtR is standardized for height and indirectly adjusts for the effect of age, which is a simple and pragmatic index to correctly assess central obesity ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

Utility of Three Adiposity Indices for Identifying Left Ventricular Hypertrophy and Geometric Remodeling in Chinese Children

et al. 2021

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BackgroundPrevious studies have shown that waist-to-height ratio (WHtR) performed similarly well when compared to body mass index (BMI) and waist circumference (WC) for identifying cardiovascular risk factors. However, to our knowledge, the performance of these three adiposity indices for identifying left ventricular hypertrophy (LVH) and left ventricular geometric (LVG) remodeling in youth has not been assessed. We aimed to determine the utility of BMI, WC and WHtR for identifying LVH and LVG in Chinese children.MethodsThis study included 1,492 Chinese children aged 6-11 years. Adiposity indices assessed were BMI, WC and WHtR. LVH and high relative wall thickness (RWT) were defined using sex- and age-specific 90th percentile values of left ventricular mass index and RWT, respectively, based on the current population. LVG remodeling included concentric remodeling (CR), eccentric hypertrophy (EH) and concentric hypertrophy (CH), which was defined based on the combination of LVH and high RWT.ResultsThe magnitude of association of central obesity defined by WHtR with LVH [odds ratio (OR) =10.09, 95% confidence interval (CI) =6.66-15.29] was similar with general obesity defined by BMI (OR=10.49, 95% CI=6.97-15.80), and both were higher than central obesity defined by WC (OR=6.87, 95% CI=4.57-10.33). Compared with BMI, WHtR had better or similar predictive utility for identifying LVH, EH, and CH [the area under the curve (AUC): 0.84 vs. 0.79; 0.84 vs. 0.77; 0.87 vs. 0.88, respectively]; WC had worse or similar discriminatory utility with AUCs of 0.73, 0.70, 0.83, respectively.ConclusionWHtR performed similarly or better than BMI or WC for identifying LVH and LVG remodeling among Chinese children. WHtR provides a simple and convenient measure of central obesity that might improve the discrimination of children with cardiac structural damage.

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Abdominal obesity and risk of CVD: a dose–response meta-analysis of thirty-one prospective studies

Cited by 44 publications

References 58 publications

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

Irisin Level in Salah Adin’s Insulin Resistance Syndrome Patients in View of Global Controversy

Utility of Three Adiposity Indices for Identifying Left Ventricular Hypertrophy and Geometric Remodeling in Chinese Children

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