Abdominal Adiposity and Physical Inactivity Are Positively Associated with Breast Cancer: A Case-Control Study

Godinho-Mota, Jordana Carolina Marques; Vaz-Gonçalves, Larissa; Soares, Leonardo Ribeiro; Mota, João Felipe; Martins, Karine A.; Freitas-Junior, Ismael F; Freitas‐Júnior, Ruffo

doi:10.1155/2018/4783710

Cited by 16 publications

(10 citation statements)

References 27 publications

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“…Our study reinforces that lifestyle variables have different associations with breast cancer risk based on menopausal status [6,8,11,13,15,27,28]. To our knowledge, this is the first study to carry out an investigation into the effects of lifestyle variables on breast cancer risk based on the menopausal status in Brazilian women.…”

Section: Discussionsupporting

confidence: 81%

“…There is evidence for a strong association between lifestyle variables and increased breast cancer risk related to menopausal status [6,8,9]. Lifestyle variables most associated with breast cancer include physical inactivity, alcohol consumption, smoking, abdominal, and total adiposity [8,9,10,11,12,13,14,15,16]. However, data currently available in the literature remain inconclusive and are limited by differing sample populations and methodological variations.…”

Section: Introductionmentioning

confidence: 99%

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Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

et al. 2019

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Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

et al. 2019

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“…In Goiânia, there is a high prevalence of alcohol consumption among adolescents, as well as the early onset of alcohol use (Coutinho et al, 2016;Nascente et al, 2016). In addition, physical inactivity, inadequate eating habits and obesity may also have contributed to this increased incidence of the disease (Nascente et al, 2016; Godinho-Mota et al, 2018). The data from the present study showed that one-fourth of the cases of breast cancer evaluated here occurred in women of 40 to 49 years of age.…”

Section: Discussionmentioning

confidence: 49%

Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis

Rahal

Rocha

Freitas‐Júnior

et al. 2019

Asian Pac J Cancer Prev

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Background:The largest radiological accident to occur in any urban area happened in Goiânia, Brazil, in 1987. One major concern regarding deleterious effects in the population was a possible increase in the breast cancer incidence. This study analyzed trends in the incidence of breast cancer over the 25-year period following the radiological accident. Methods: This ecological, population-based study was conducted to determine the incidence of breast cancer in female residents of Goiânia, Goiás, Brazil, between 1988 and 2012. The data were collected from the Goiânia population-based cancer registry. Crude and age-standardized incidence rates were calculated. The Joinpoint software program was used to calculate annual percent changes (APC) in the incidence of breast cancer. Results: Overall, 7,365 new cases of breast cancer were identified, with an annual crude incidence rate of 23.09/100,000 women in 1988 and of 71.65/100,000 women in 2012. The age-standardized incidence rate was 35.63/100,000 women in 1988 and 65.63/100,000 women in 2012. Analysis of the APC showed a significant annual increase of 4.8% in the incidence between 1988 and 2005 (p<0.0001) followed by stabilization in 2005-2012, with an APC of -3.5% (p=0.1). Conclusion: There was an increase in the incidence of breast cancer in the female residents of Goiânia, Goiás in the first 17 years of evaluation (1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) followed by a period of stabilization until 2012. However, the trends in the incidence suggest a lack of association with the radiological accident.

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“…The prevalence of breast cancer is increasing . Mammographic density, body fat, and diet are the risk factors for breast cancer . The 12th St Gallen International Breast Cancer Conference proposed that breast cancer be divided into four subtypes using immunohistochemical definitions of estrogen and progesterone receptors, the human epidermal growth factor receptor 2 (HER2), and the Ki‐67 labeling, index including Luminal A, Luminal B, HER2, and Triple negative (ductal) subtypes .…”

Section: Introductionmentioning

confidence: 99%

Identification of competitive endogenous RNAs network in breast cancer

Wang

Wan

et al. 2019

Cancer Medicine

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Background MiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer. In this study, a ceRNA network was constructed, and new treatment and prognosis targets and biomarkers for breast cancer were explored. Methods A total of 1 096 cancer tissues and 112 adjacent normal tissues to cancer from the TCGA database were used to screen out significant differentially expressed mRNAs (DEMs), lncRNAs (DELs), and miRNAs (DEMis) to construct a ceRNA network. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to predict potential functions. Survival analysis was performed to predict which functions were significant for prognosis. Results From the analysis, 2 139 DEMs, 1 059 DELs, and 84 DEMis were obtained. Targeting predictions for DEMis‐DELs and DEMis‐DEMs can yield 26 DEMs, 90 DELs, and 18 DEMis. We performed GO enrichment analysis, and the results showed that the upregulated DEMs were involved in nucleosomes, extracellular regions, and nucleosome assembly, while the downregulated DEMs were mainly involved in Z disk, muscle contraction, and structural constituents of muscle. KEGG pathway analysis was performed on all DEMs, and the pathways were enriched in retinol metabolism, steroid hormone biosynthesis, and tyrosine metabolism. Through survival analysis of the ceRNA network, we identified four DEMs, two DELs, and two DEMis that were significant for poor prognosis. Conclusions This study suggested that constructing a ceRNA network and performing survival analysis on the network could screen out new significant treatment and prognosis targets and biomarkers.

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Abdominal Adiposity and Physical Inactivity Are Positively Associated with Breast Cancer: A Case-Control Study

Cited by 16 publications

References 27 publications

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis

Identification of competitive endogenous RNAs network in breast cancer

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