ABC Triblock Copolymer Micelles: Spherical Versus Worm-Like Micelles Depending on the Preparation Method

Ghasdian, Negar; Buzza, D. Martin A.; Fletcher, Paul D. I.; Georgiou, Theoni K.

doi:10.1002/marc.201400621

Cited by 19 publications

(17 citation statements)

References 39 publications

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“…Figure 3(a) shows that the average particle size of gPEGCe6-IMTP (prepared after simply dissolving gPEG-Ce6-IMTP into PBS) was approximately 10 nm in diameter, indicating that gPEG-Ce6-IMTP did not need any special particle preparation method such as diafilteration, film rehydration, water emulsion, or the supercritical fluid method. 20 The image obtained from TEM illustrates that the extremely small-sized gPEGCe6-IMTP were almost spherical (Figure 3(b)). …”

Section: Resultsmentioning

confidence: 96%

Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Youn

et al. 2016

Macromol. Res.

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In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the - carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery.

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Section: Resultsmentioning

confidence: 96%

Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Youn

et al. 2016

Macromol. Res.

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“…In addition to polymer composition, the solution processing method employed can drastically alter the resulting micelle organization of a block polymer in solution . Therefore, in order to decouple the effects of polymer composition and processing method, DLS experiments were performed on solutions of ISD‐15 processed by thin film resolvation, ISD‐22 processed by thin film resolvation, and ISD‐22 processed by bulk dissolution.…”

Section: Resultsmentioning

confidence: 99%

Solution self‐assembly behavior of A‐B‐C triblock polymers and the implications for nanoporous membrane fabrication

Sargent

Hoss

Phillip

et al. 2017

J of Applied Polymer Sci

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Self‐assembled block polymer membranes are rising to the fore of next‐generation separations technologies, and a particular fabrication process of significant interest is the self‐assembly and non‐solvent induced phase‐separation (SNIPS) method. This is because the SNIPS process allows for the facile manipulation of independent variables to produce simultaneously size‐ and chemically‐selective membranes in a scalable manner. Despite significant advances in the SNIPS membrane fabrication procedure, the early‐stage solution behavior of many of the polymer–solvent systems employed is still poorly understood. This work addresses the challenges posed by these systems and illuminates guiding relationships for the optimization of SNIPS membrane casting solutions. Specifically, polymer aggregate structures and critical micelle concentration (CMC) values are determined for an A‐B‐C triblock polymer dissolved in 1,4‐dioxane using a combination of scattering and atomic force microscopy techniques. The CMC of this system ranges from 20 to 80 μM and shows a strong dependence on the polymer composition and solution processing method. Additionally, the shape of the self‐assembled structures in solution can be altered by varying these parameters. These studies establish the relationships between polymer solution properties (i.e., the block polymer composition and the processing method) and assembly behavior as they impact membrane fabrication through SNIPS processing. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45531.

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“…[ 27 ] In order to prove that TMSPMA can easily be homoand copolymerized with GTP, several polymers were synthesized. The polymers were synthesized similarly to previous GTP studies on linear block copolymers [28][29][30][31][32][33] and star polymers. [34][35][36] The polymerization catalyst, solvent, and initiator were added in a round-bottom fl ask and then the monomer(s) were syringed sequentially.…”

Section: Resultsmentioning

confidence: 99%

Toward Hybrid Materials: Group Transfer Polymerization of 3‐(Trimethoxysilyl)propyl Methacrylate

Chung

Jones

Georgiou

2015

Macromol. Rapid Commun.

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ABC Triblock Copolymer Micelles: Spherical Versus Worm-Like Micelles Depending on the Preparation Method

Cited by 19 publications

References 39 publications

Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Solution self‐assembly behavior of A‐B‐C triblock polymers and the implications for nanoporous membrane fabrication

Toward Hybrid Materials: Group Transfer Polymerization of 3‐(Trimethoxysilyl)propyl Methacrylate

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