Abbau Von Steroiden

Enzyme haben als Katalysatoren in der organischen Synthese eine grol3e Zukunft. Bisher sind ihre Anwendungen auf einige industriell in groDem MaRstab durchgefiihrte Hydrolysen sowie die Herstellung zahlreicher Reagentien fur Analysen und Synthesen im Laboratoriumsmahtab beschrankt. Verbesserungen bei der Produktion von Enzymen, die zum einen auf neuen Erkenntnissen der klassischen Mikrobiologie und zum anderen auf ersten erfolgversprechenden Ansatzen der Gentechnologie beruhen, sowie bei ihrer Stabilisierung und Handhabung machen diese Katalysatoren fur einen Gebrauch in der organischen Synthese immer attraktiver. Dieser Aufsatz beschreibt den aktuellen Stand auf dem sich schnell entwickelnden Gebiet der enzymkatalysierten organischen Synthese; daneben werden auch die Entwicklungsmoglichkeiten erortert.

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Enzyme in der organischen Synthese

Whitesides

Wong

1985

Angew. Chem.

133

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Enzymes as Catalysts in Synthetic Organic Chemistry [New Synthetic Methods (53)]

Whitesides

Wong

1985

Angew. Chem. Int. Ed. Engl.

449

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Pages 61 7-71 8 New Synthetic Methods (53)Enzymes have great potential as catalysts for use in synthetic organic chemistry. Applications of enzymes in synthesis have so far been limited to a relatively small number of largescale hydrolytic processes used in industry, and to a large number of small-scale syntheses of materials used in analytical procedures and in research. Changes in the technology for production of enzymes (in part attributable to improved methods from classical microbiology, and in part to the promise of genetic engineering) and for their stabilization and manipulation now make these catalysts practical for wider use in large-scale synthetic organic chemistry. This paper reviews the status of the rapidly developing field of enzyme-catalyzed organic synthesis, and outlines both present opportunities and probable future developments in this field.

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Mikrobielle hydrierung des aromatischen systems von 17α-äthinylöstradiol

Schubert¹,

Rose²,

Hörhold³

1973

Journal of Steroid Biochemistry

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Abbau Von Steroiden

Cited by 7 publications

References 20 publications

Enzyme in der organischen Synthese

Enzyme in der organischen Synthese

Enzymes as Catalysts in Synthetic Organic Chemistry [New Synthetic Methods (53)]

Mikrobielle hydrierung des aromatischen systems von 17α-äthinylöstradiol

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