Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine

Nakamura, Tomonori; Sakai, Akiko; Isogami, Issei; Noda, Kazutaka; Ueno, Koichi; Yano, Shingo

doi:10.1254/jjp.88.217

Cited by 35 publications

(29 citation statements)

References 14 publications

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“…The mechanism of DKT is gradually elucidated; several studies show that DKT accelerates the gastrointestinal transit [9][10][11][12][13][14][15]. As delayed intestinal transit could be responsible for increased endoluminal bacterial overgrowth, DKT may have a positive effect in preventing this occurring.…”

Section: Introductionmentioning

confidence: 99%

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

et al. 2008

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Kampo medicine "Dai-kenchu-to" (DKT) has been used for treatment of ileus. The aim of this study was to evaluate the role of DKT on the bacterial translocation (BT) model in rats. Rats were divided into the following four groups: group 1, receiving only water, and groups 2, 3, and 4, receiving 100, 300, and 1,000 mg/kg/day of DKT. Rats were sacrificed 6 days after the beginning of the fast, and then the mesenteric lymph node was cultured. Inflammatory cytokines, intestinal integrity, and apoptosis were assessed. Incidence of BT in groups 3 (33%) and 4 (16%) was lower than in group 1 (66%). Interferon-gamma expression in groups 2, 3, and 4 was significantly lower than in group 1. Villous height and number of villus in groups 2, 3, and 4 were significantly taller and greater than in group 1. Apoptotic index in groups 2, 3, and 4 was significantly lower than in group 1. This is the first evidence that DKT prevents BT by reducing inflammatory reaction and maintaining intestinal integrity.

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Section: Introductionmentioning

confidence: 99%

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

et al. 2008

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“…For example, a Chinese herbal medicine, known as Rikkunshi-to and TJ-43, has been reported to enhance gastric emptying (30) and gastric adaptive relaxation (31). It has been demonstrated that daikenchuto, a Japanese herbal medicine comprised of four herbs, is able to ameliorate morphine-induced inhibition of intestinal and colonic transit (32). However, the optimal therapeutic strategy for FGID remains to be determined due to the poorly defined pathogenesis of the condition.…”

Section: Discussionmentioning

confidence: 99%

Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats

Choi

Zheng

Park³

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. LD02GIFRO is a novel prokinetic agent formulated with Poncirus fructus and Zanthoxylum sp. fruits. The aim of the present study was to evaluate the effect of LD02GIFRO on delayed gastrointestinal transit (GIT) and colorectal hypersensitivity. To investigate the effect of LD02GIFRO, a rat model of delayed GIT was induced via three mechanisms; postoperative ileus (POI), morphine, and POI plus morphine. Visceromotor responses (VMR) to colorectal distension (CRD) were also evaluated. POI was induced by laparotomy surgery and manipulation of the small intestine under anesthesia, and GIT was calculated by measuring the length that Evans Blue travelled through the gastrointestinal tract in a given time. Oral administration of 260 mg/kg LD02GIFRO caused Evans Blue to migrate significantly further in the delayed GIT models induced by POI, morphine and POI plus morphine compared with the control (P<0.05). This effect was inhibited by atropine, a muscarinic receptor antagonist, and completely abolished by GR125487, a 5-HT 4 -receptor antagonist. Furthermore, intraperitoneal administration of 600 and 900 mg/kg LD02GIFRO significantly reduced VMR to CRD in acute and chronic colorectal hypersensitive rat models, induced by acetic acid and trinitrobenzenesulfonic acid, to almost normal levels (P<0.01). In the present study, LD02GIFRO successfully ameliorated delayed GIT models and colorectal hypersensitivity models, suggesting that LD02GIFRO may be an effective therapeutic treatment for patients with functional gastrointestinal disorders and abnormalities in GIT.

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“…23 Daikenchuto is thought to have a restorative effect on delayed gastrointestinal transit in duced by intestinal manipulation and morphine administration. 22,24 Although a total gastrectomy is widely performed for the treatment of gastric carcinoma, there is no general agreement about ideal reconstruction. To provide reservoir function and to improve nutritional conditions, many types of jejunal pouch reconstruction have been described and evaluated.…”

Section: Effect Of Dkt On Postoperative Ileusmentioning

confidence: 99%

The effect of traditional Japanese medicine (Kampo) on gastrointestinal function

et al. 2010

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Traditional Japanese medicine (Kampo) is used to treat various disorders of the gastrointestinal tract in Japan, where it is fully integrated into the modern healthcare system. Recently, scientific research on herbal medicine in Japan has been reported in English journals. The objective of the current review is to introduce two traditional Japanese medicines and to provide evidenced-based information regarding their use. Daikenchuto, which consists of three different herbs, is the most frequently prescribed traditional Japanese medicine in Japan. Daikenchuto stimulates gastrointestinal motility though a neural reflex involving presynaptic cholinergic and 5-HT3 receptors. Daikenchuto improves postoperative bowel motility and postoperative ileus. Furthermore, it is reported to cause an increase in gastrointestinal hormones (motilin, vasoactive intestinal peptide, and calcitonin gene-related peptide) and intestinal blood flow. Rikkunshito, a traditional Japanese medicine consisting of eight herbs, is thought to stimulate gastrointestinal motility and ghrelin secretion. Rikkunshito is effective for improving the symptoms of functional dyspepsia, gastroesophageal reflux disease, and cisplatin-induced anorexia and vomiting. Traditional Japanese medicine has the potential to be used successfully in the treatment of gastrointestinal disorders. Details regarding the physiological and clinical effects of traditional Japanese medicine must be further examined in order to become more widely accepted in other countries.

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Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine

Cited by 35 publications

References 14 publications

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats

The effect of traditional Japanese medicine (Kampo) on gastrointestinal function

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