A γ-cyclodextrin-based metal–organic framework (γ-CD-MOF): a review of recent advances for drug delivery application

Regularities of Encapsulation of Tolfenamic Acid and Some Other Non-Steroidal Anti-Inflammatory Drugs in Metal-Organic Framework Based on γ-Cyclodextrin

“…To date, there are a number of publications devoted to the immobilization of NSAIDs in γCD-MOF [ 23 , 24 , 25 , 26 , 27 , 28 ]. The loaded NSAIDs (TA, niflumic acid [ 30 ], ibuprofen [ 23 , 24 ], ketoprofen [ 27 ], fenbufen [ 26 ], flurbiprofen [ 28 ]) have different structures and physicochemical properties ( Table S3 ). Therefore, it was interesting to analyze the influence of these factors on the efficiency of the drug loading in γCD-MOF.…”

“…To the best of our knowledge, a number of non-steroidal anti-inflammatory drugs (NSAIDs) have been loaded in CD-MOFs [ 23 , 24 , 25 , 26 , 27 , 28 ]. Non-steroidal anti-inflammatory drugs are one of the most popular and commonly applied classes of medication widely used to relieve pain and reduce inflammation.…”

“…The low aqueous solubility and unwanted side effects of NSAIDs encourage the design of the drug delivery systems [ 29 ]. As is known from the literature, CD-MOFs can be a suitable platform for the loading of ibuprofen [ 23 , 24 ], diclofenac [ 25 ], fenbufen [ 26 ], ketoprofen [ 27 ], and flurbiprofen [ 28 ]. In our recent work, the number of encapsulated NSAIDs was increased—niflumic acid was loaded in γCD-MOF by absorption and co-crystallization methods [ 30 ].…”

“…Therefore, it was interesting to reveal the main regularities demonstrating the influence of the NSAID structure on the loading efficiency in γCD-MOF. This relationship was established for the first time on the basis of the comparative analysis of our own experiments, and is available in the literature [ 24 , 26 , 27 , 28 , 30 ] data. The revealed relationship could be a predictive tool in the design of drug delivery systems for NSAIDs.…”

Environmentally Friendly Zr-Based MOF for Pesticide Delivery: Ultrahigh Loading Capacity, pH-Responsive Release, Improved Leaf Affinity, and Enhanced Antipest Activity

“…A metal–organic framework (MOF) is an organic–inorganic hybrid material, which has attracted widespread attention since it was proposed. It has been widely used in material storage, separation, purification, catalysis, sensing, biological imaging, energy storage, and drug delivery. − Compared with traditional materials, MOFs have many unique properties in drug delivery systems. The large porosity, high porosity, and huge specific surface area of MOFs contribute to improved drug loading efficiency, while its easy surface functionalization, good stability, and biocompatibility further expand its availability. , Based on the extensive research of MOFs in drug delivery and biomedicine, MOF-based multifunctional PDS has attracted more and more attention in recent years. − For example, Shan et al synthesized a Fe-based MOF (NH 2 -Fe-MIL-101) for diniconazole (Dini) delivery.…”