A Volumetric Study of the Corpus Callosum in the Turkish Population

Abstract

Objective The aim of this study is to measure the average corpus callosum (CC) volume of healthy Turkish humans and to analyze the effects of gender and age on volumes, including the genu, truncus, and splenium parts of the CC. Patients and Methods Magnetic resonance imaging brain scans were obtained from 301 healthy male and female subjects, aged 11 to 84 years. The median age was 42 years (min–max: 11–82) in females and 49 years (min–max: 12–84) in males. Corpus callosum and its parts were calculated by using MRICloud. CC volumes of each subject were compared with those of the age and gender groups. Results All volumes of the CC were significantly higher in males than females. All left volumes except BCC were significantly higher than the right volumes in both males and females. The oldest two age groups (50–69 and 70–84 years) were found to have higher bilateral CC volumes, and bilateral BCC volumes were also higher than in the other two age groups (11–29 and 30–49 years). Conclusion The results suggest that compared with females/males, females have a faster decline in the volume of all volumes of the CC. We think that quantitative structural magnetic resonance data of the brain is vital in understanding human brain function and development.

Three dimensional development and asymmetry of the corpus callosum in the 0–18 age group: A retrospective magnetic resonance imaging study

“…However, this study supports the longitudinal study of Giedd et al due to the similar increase rate of CC's development segments (Giedd et al, 1999). Soysal et al investigated CC volume in a wide age range with MRICloud in a recent study (Soysal et al, 2022). The CC median value they found in the 11–29 age range was close to the mean value for the 11–18 age range of our study.…”

“…Soysal et al examined the volumetric status of CC with MRICloud in 11‐84‐year‐olds. They found that the volumes of both total CC and subregions of CC were significantly greater in males (Soysal et al, 2022). This study's mean CC volume values of the 11–18 age group were very close to the 11–29 age group of Soysal et al Therefore, we think sexual dimorphism is not caused by the immature CC period.…”

“…Studies reporting volumetric data of CC in middle childhood and adolescence are limited (Ansado et al, 2015;Soysal et al, 2022).…”

“…Studies reporting volumetric data of CC in middle childhood and adolescence are limited (Ansado et al, 2015; Soysal et al, 2022). However, to our knowledge, the 3D development of CC in infancy and early childhood has not been reported.…”