Three dimensional development and asymmetry of the corpus callosum in the 0–18 age group: A retrospective magnetic resonance imaging study

Işiklar, Sefa; Ozdemir, Senem Turan; Özkaya, Güven; Özpar, Rıfat

doi:10.1002/ca.23996

Cited by 9 publications

(2 citation statements)

References 68 publications

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“…Within a similar age range (8–30 years), Koolschijn and Crone (2013) reported larger cerebellar grey matter volume in males than in females (controlling for ICV). The sparse sex effects in the QTAB dataset are similar to the results in adolescents reported by Isiklar et al (2023) and Gaiser et al (2024). However, these results are inconsistent with the findings of Rice et al (2023), in which a greater number of regions showed significant sex effects (controlling for ICV) in similarly aged participants.…”

Section: Discussionsupporting

confidence: 88%

Heritability of cerebellar subregion volumes in adolescent and young adult twins

Strike,

Kerestes,

McMahon

et al. 2024

Human Brain Mapping

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Twin studies have found gross cerebellar volume to be highly heritable. However, whether fine‐grained regional volumes within the cerebellum are similarly heritable is still being determined. Anatomical MRI scans from two independent datasets (QTIM: Queensland Twin IMaging, N = 798, mean age 22.1 years; QTAB: Queensland Twin Adolescent Brain, N = 396, mean age 11.3 years) were combined with an optimised and automated cerebellum parcellation algorithm to segment and measure 28 cerebellar regions. We show that the heritability of regional volumetric measures varies widely across the cerebellum ( 47%–91%). Additionally, the good to excellent test–retest reliability for a subsample of QTIM participants suggests that non‐genetic variance in cerebellar volumes is due primarily to unique environmental influences rather than measurement error. We also show a consistent pattern of strong associations between the volumes of homologous left and right hemisphere regions. Associations were predominantly driven by genetic effects shared between lobules, with only sparse contributions from environmental effects. These findings are consistent with similar studies of the cerebrum and provide a first approximation of the upper bound of heritability detectable by genome‐wide association studies.

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Section: Discussionsupporting

confidence: 88%

Heritability of cerebellar subregion volumes in adolescent and young adult twins

Strike,

Kerestes,

McMahon

et al. 2024

Human Brain Mapping

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“…Previous studies have con rmed that CC played an important role in regulating motor and non-motor functions in PD [14][15][16]. Nevertheless, CC is not a homogeneous component which the segments connecting to different cortical regions vary in ber size and density [13] and it may develop asymmetrically during growth [17]. Therefore, we speculate that differences in degenerative patterns of CC may be one of the potential mechanisms affecting the nonmotor symptoms and prognosis in PD patients with unilateral onset.…”

Section: Introductionmentioning

confidence: 99%

Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study

Chen,

Wu,

Zhou

et al. 2024

Preprint

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Background The laterality of motor symptoms is an important clinical feature of PD, which is not only manifested as the lateral dysfunctions of limbs but also affects the non-motor symptoms and the prognosis in PD patients. Former studies suggested that the compensatory mechanisms in the dominant hemisphere of brain may be an underlying explanation. The corpus callosum (CC) is the largest fiber connecting the two hemispheres of brain. Considering CC as the pointcut may help to explore the mechanism of the laterality of motor symptoms affecting the non-motor symptoms and prognosis in PD patients. Purpose To explore microstructural degeneration of CC in PD patients with unilateral motor symptoms onset based on the bi-tensor model of diffusion imaging technology, and further explore the relationship with motor and non-motor performance. Methods A total of 201 right-handed PD patients with unilateral motor symptoms onset were included in this study, including 91 patients with left-onset (LPD) and 110 with right-onset (RPD), as well as 100 right-handed healthy controls (HC). A bi-tensor model of diffusion tensor imaging (DTI) was applied to obtain free-water (FW), as well as fractional anisotropy (FAT) and mean diffusivity (MDT) after correcting free-water. CC was divided into halves by the median sagittal line, and each was further divided into five functional segments manually according to the specific template. A total of 10 subregions were obtained and numbered in sequence. The laterality index (LI) was calculated to quantify the asymmetry of CC and its segments. The general linear model was used for the comparisons among groups, and then partial correlation analysis was performed to explore the relationship between the diffusion parameters of CC subregions and clinical manifestations. Results Compared with HC, FW and FAT of CC in bilateral hemispheres were decreased in LPD group, while MDT in right hemisphere was increased. In LPD group, FAT of all CC subregions except for subregions 1, 3 and 6 were significantly lower than HC, and MDT in anterior and posterior segments of CC (CC subregions 1, 5, 6, 7 and 10) were significantly higher than HC. In RPD group, FAT of subregion 7 was significantly decreased and MDT was increased than HC. The LI analysis of CC reflected significant interhemispheric FAT asymmetry of the anterior and middle segments of CC in RPD group, with a more significant reduction in the right hemisphere of CC. Moreover, the degeneration in CC and its subregions was related to motor or non-motor symptoms in PD. Conclusions Extensive damage of CC was observed in LPD group than in RPD group, while asymmetrical damage was found in the anterior and middle segments of CC in RPD group, suggesting that differences in the patterns of callosal degeneration may be one of the potential mechanisms of asymmetrical motor symptoms affect the non-motor symptoms and prognosis in PD.

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Volume Measurements of the Corpus Callosum Volume Using MRI

Acer,

Turgut,

Tokpınar

2023

The Corpus Callosum

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Three dimensional development and asymmetry of the corpus callosum in the 0–18 age group: A retrospective magnetic resonance imaging study

Cited by 9 publications

References 68 publications

Heritability of cerebellar subregion volumes in adolescent and young adult twins

Heritability of cerebellar subregion volumes in adolescent and young adult twins

Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study

Volume Measurements of the Corpus Callosum Volume Using MRI

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