A vesiculo-bullous disease in pigs resembling foot and mouth disease I. Field cases

Montgomery, J. F.; Oliver, R.E.; Poole, William

doi:10.1080/00480169.1987.35369

Cited by 30 publications

(16 citation statements)

References 15 publications

(1 reference statement)

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“…However, association of SV-A with SIVD, or as the sole causative agent, is speculative at this time since the virus has also been isolated from pigs lacking clinical disease [2]. SIVD has been reported in pigs in the continents of North America and Australia [6,[9][10][11]. Although SIVD itself does not pose an economic concern, veterinary diagnosis from clinical signs is complicated since similar vesicular lesions can be formed due to common viral infections such as parvovirus, enterovirus, toxins in food supply, or burns [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Reverse Transcription PCR Assay for Detection of Senecavirus A in Swine Vesicular Diagnostic Specimens

et al. 2016

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Senecavirus A (SV-A), formerly, Seneca Valley virus (SVV), has been detected in swine with vesicular lesions and is thought to be associated with swine idiopathic vesicular disease (SIVD), a vesicular disease syndrome that lacks a defined causative agent. The clinical presentation of SIVD resembles that of other more contagious and economically devastating vesicular diseases, such as foot-and-mouth disease (FMD), swine vesicular disease (SVD), and vesicular stomatitis (VS), that typically require immediate rule out diagnostics to lift restrictions on animal quarantine, movement, and trade. This study presents the development of a sensitive, SYBR Green RT-qPCR assay suitable for detection of SV-A in diagnostic swine specimens. After testing 50 pigs with clinical signs consistent with vesicular disease, 44 (88%) were found to be positive for SV-A by RT-qPCR as compared to none from a negative cohort of 35 animals without vesicular disease, indicating that the assay is able to successfully detect the virus in an endemic population. SV-A RNA was also detectable at a low level in sera from a subset of pigs that presented with (18%) or without (6%) vesicular signs. In 2015, there has been an increase in the occurrence of SV-A in the US, and over 200 specimens submitted to our laboratory for vesicular investigation have tested positive for the virus using this method. SV-A RNA was detectable in all common types of vesicular specimens including swabs and tissue from hoof lesions, oral and snout epithelium, oral swabs, scabs, and internal organ tissues such as liver and lymph node. Genome sequencing analysis from recent virus isolates was performed to confirm target amplicon specificity and was aligned to previous isolates.

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Section: Introductionmentioning

confidence: 99%

Real-Time Reverse Transcription PCR Assay for Detection of Senecavirus A in Swine Vesicular Diagnostic Specimens

et al. 2016

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“…porcine idiopathic vesicular disease is a sporadic condition affecting swine and can cause erosions and vesicles on the hooves, snout, oral cavity and coronary bands (Segales, Barcellos, Alfieri, Burrough, & Marthaler, ). This disease has been reported in swine from Canada (Pasma et al., ), New Zealand (Montgomery, Oliver, & Poole, ; Montgomery, Oliver, Poole, & Julian, ), United States (Amass et al., ; Canning et al., ), Australia (Munday & Ryan, ) and Italy (Sensi et al., ). In all the above cases, vesicular diseases such as foot‐and‐mouth disease virus (FMDV), swine vesicular disease virus (SVDV), vesicular stomatitis virus (VSV) and vesicular exanthema of swine virus (VESV) had been ruled out.…”

Section: Introductionmentioning

confidence: 82%

Phylogenetic and genome analysis of seven senecavirus A isolates in China

Zhao

Bai

et al. 2017

Transbound Emerg Dis

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Senecavirus A (SVA) is the only member of genus Senecavirus that causes vesicular lesions in pigs. We have characterized seven SVA isolates from different swine farms in Guangdong, China. The most variable isolate, CH-DL-01-2016, contained a single amino acid insertion at position 219-220 and a 16 amino acid insertion at position 250-251. The VP1 protein also had four nucleotide changes when compared to 31 other SVA VP1 sequences obtained from GenBank. These mutations have not been identified before. Phylogenetic trees demonstrated that the new SVA isolates were clustered into two different clades and shared 96.3%-97.1% similarity with US strains and 97.9%-98.3% similarity with Brazilian stains on nucleotide level, respectively. Prediction of antigenic epitope indicated that SVA VP1 protein contained both potential B-cell and potential T-cell epitopes. This report provides information about variation analysis in SVA in southern China.

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“…Porcine idiopathic vesicular disease, characterized by vesicles and ulcers around the snout, coronary band and in the oral cavity of pigs, was reported in Canada, USA (Amass et al., ; Canning et al., ), Italy (Sensi et al., ), Australia (Munday and Ryan, ), Brazil (Leme et al., ; Vannucci et al., ) and New Zealand (Montgomery et al., ,b). In several field cases in New Zealand, the vesicular lesions were associated with feeding on, or contact with, the leaves of parsnips or celery and exposure to sunlight (Montgomery et al., ).…”

Section: Discussionmentioning

confidence: 99%

The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

Zhao

Bai

et al. 2016

Transbound Emerg Dis

141

113

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Senecavirus A (SVA) infection was recently confirmed in pigs in Brazil. In March, 2015, an outbreak of vesicular disease occurred in Guangdong, China, characterized by vesicular lesions in sows and acute death of neonatal piglets. Cumulative incidence of porcine idiopathic vesicular disease in farm A was 258, which had a total number of 5500 sows. Sows in farm B displayed typical vesicular symptoms by May, 2015, which also had 5500 sows. A total of 278 and 142 of 5500 sows in farm B demonstrated lame and presented vesicles, respectively, associated with a total of 186 mortality in piglets. Routine differential diagnoses for swine vesicular disease were carried out to exclude infection with foot-and-mouth disease virus, swine vesicular disease virus, vesicular exanthema of swine virus and vesicular stomatitis virus. In this study, seven pairs of primer were designed to amplify the complete genome of SVA in RT-PCR assays. Sequence alignment showed that this Chinese strain shares 94.4-97.1% sequence identity to other eight strains of SVA. This is the first report of SVA in China and provides information about the association between SVA infection and vesicular disease.

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A vesiculo-bullous disease in pigs resembling foot and mouth disease I. Field cases

Cited by 30 publications

References 15 publications

Real-Time Reverse Transcription PCR Assay for Detection of Senecavirus A in Swine Vesicular Diagnostic Specimens

Real-Time Reverse Transcription PCR Assay for Detection of Senecavirus A in Swine Vesicular Diagnostic Specimens

Phylogenetic and genome analysis of seven senecavirus A isolates in China

The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

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