The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

Abstract

Senecavirus A (SVA) infection was recently confirmed in pigs in Brazil. In March, 2015, an outbreak of vesicular disease occurred in Guangdong, China, characterized by vesicular lesions in sows and acute death of neonatal piglets. Cumulative incidence of porcine idiopathic vesicular disease in farm A was 258, which had a total number of 5500 sows. Sows in farm B displayed typical vesicular symptoms by May, 2015, which also had 5500 sows. A total of 278 and 142 of 5500 sows in farm B demonstrated lame and presented vesicles, respectively, associated with a total of 186 mortality in piglets. Routine differential diagnoses for swine vesicular disease were carried out to exclude infection with foot-and-mouth disease virus, swine vesicular disease virus, vesicular exanthema of swine virus and vesicular stomatitis virus. In this study, seven pairs of primer were designed to amplify the complete genome of SVA in RT-PCR assays. Sequence alignment showed that this Chinese strain shares 94.4-97.1% sequence identity to other eight strains of SVA. This is the first report of SVA in China and provides information about the association between SVA infection and vesicular disease.

Emergence of novel Seneca Valley virus strains in China, 2017

“…In China, SVV has been detected in sporadic and transient outbreaks of PIVD. In the beginning of 2015, the first case of SVV infection in China was identified in Guangdong province, characterized by vesicular lesions in sows and acute death of neonatal piglets (Wu et al., ), and the causative strain was designated as SVV CH‐01‐2015. Subsequently, six new SVV isolates in six different farms in Guangdong province were identified from May 2015 to January 2016, and phylogenetic analysis grouped them into two different clades (Zhao et al., ).…”

A new wave of Seneca Valley virus outbreaks in Brazil

“…After the SVV outbreaks in Brazil, the virus infection was also reported in different pig categories/herds of other countries of the Americas (Joshi et al., ; Sun, Vannucci, Knutson, Corzo, & Marthaler, ; Xu et al., ) and Asia (Saeng‐Chuto, Rodtian, Temeeyasen, Wegner, & Nilubol, ; Wu et al., ) during 2015 and 2016. However, the number of field reports on SVV‐suspected cases in piglets and SVV diagnostics has decreased in Brazilian pig herds during 2017, suggesting that the infection became endemic in pig herds, leading to asymptomatic and/or subclinical infections.…”

The first detection of Senecavirus A in pigs in Thailand, 2016

“…Since its first isolation as a contaminant of the PER.C6 cell line in 2001, SVA has been detected in pigs and is associated with idiopathic vesicular disease (IVD). At present, the virus has been reported in Canada, Brazil, the United States and China (Guo et al., ; Hause, Myers, Duff, & Hesse, ; Leme et al., ; Pasma, Davidson, & Shaw, ; Wu et al., ). We herein reported the first detection of SVA in a pig farm in Thailand in 2016.…”