A unique insight for Xiaoyao San exerts antidepressant effects by modulating hippocampal glucose catabolism using stable isotope-resolved metabolomics

Wu, Wen-ze; Linghu, Ting; Zhao, Yun-hao; Zhao, Wei-di; Ji, Cui; Tian, Jun-Sheng; Ren, Yan; Qin, Xuemei

doi:10.1016/j.jep.2022.115702

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…SD male rats were adaptively fed for 7 d. The rats were randomly divided into four groups: control group (C, n = 6), CUMS control group (M, n = 6), Venlafaxine positive treatment group (V, n = 6), and XYS treatment group (X, n = 6). The dose of Venlafaxine was 35 mg/kg, and the doses of XYS was 2.12 g/mL (crude drug), which were based on the effective dose reported in previous research ( Wu et al, 2023 ). The above drugs were dissolved in distilled water, and the rats were given intragastrically once a day at a dose of 10 mL/(kg·d) for 28 consecutive days.…”

Section: Methodsmentioning

confidence: 99%

“…The test was conducted in a quiet environment, with each rat gently placed in the central square of the cage. The rats were first allowed to acclimatize for 1 min and then the number of crossings to different squares and the number of rearing in the open field were recorded for the next 4 min ( Wu et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

“…Xiaoyao San (XYS) is a traditional Chinese herbal medicine formula that has been prescribed for treatment of depression ( Wang et al, 2023 ). The formula consists of Bupleuri Radix (Chaihu in Chinese), Angelicae Sinensis Radix (Danggui in Chinese), Paeoniae Radix Alba (Baishao in Chinese), Atractylodis Macrocephalae Rhizoma (Baizhu in Chinese), Poria (Fuling in Chinese), Glycyrrhizae Radix et Rhizoma (Gancao in Chinese), Menthae Haplocalycis Herba (Bohe in Chinese), and Zingiberis Rhizoma Recens (Shengjiang in Chinese) ( Wu et al, 2023 ). Both experimental studies and clinical applications have shown evidence that XYS is effective in ameliorating depression symptoms ( Man et al, 2014 , Chen et al, 2020 , Zeng et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Zhao,

Ji,

Zheng

et al. 2024

Chinese Herbal Medicines

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Zhao,

Ji,

Zheng

et al. 2024

Chinese Herbal Medicines

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“…For example, it has been demonstrated that chronic fluoxetine treatment enhances the expression of components of the pyruvate dehydrogenase complex in the frontal cortex of prenatal stress‐induced depressive rats 97 . Wu et al 98 . have also demonstrated that the antidepressant XiaoYaoSan increases the enzyme activity of lactate dehydrogenase in the hippocampus of CUMS rats, indicating that the antidepressant can modulate the disorders of glucose catabolism in chronic stress‐caused depressive rats.…”

Section: Antidepressants and Mitochondriamentioning

confidence: 99%

Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems

Jiang,

Wang,

Sheng

2024

CNS Neurosci Ther

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BackgroundDepression is the most disabling neuropsychiatric disorder, causing difficulties in daily life activities and social interactions. The exact mechanisms of depression remain largely unclear. However, some studies have shown that mitochondrial dysfunction would play a crucial role in the occurrence and development of depression.AimsTo summarize the known knowledge about the role of mitochondrial dysfunction in the pathogenesis of depression.MethodsWe review the recent literature， including 105 articles, to summarize the mitochondrial energy metabolism and quality control systems in the occurrence and development of depression. Some antidepressants which may exert their effects by improving mitochondrial function are also discussed.ResultsImpaired brain energy metabolism and (or) damaged mitochondrial quality control systems have been reported not only in depression patients but in animal models of depression. Although the classical antidepressants have not been specially designed to target mitochondria, the evidence suggests that many antidepressants may exert their effects by improving mitochondrial function.ConclusionsThis brief review focuses on the findings that implicate mitochondrial dysfunction and the quality control systems as important etiological factors in the context of depressive disorders. It will help us to understand the various concepts of mitochondrial dysfunction in the pathogenesis of depression, and to explore novel and more targeted therapeutic approaches for depression.

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“…M + 0 indicates that the compound is12 C, no13 C; M + 1 indicates that the compound has a 13 C; M + 2 indicates that the compound has two13 C; M + 3 indicates that the compound has three13 C; M + 4 indicates that the compound has four13 C; M + 5 indicates that the compound has five 13 C; M + 6 indicates…”

mentioning

confidence: 99%

Stable Isotope Tracer Technique and Network Pharmacology to Reveal Antidepressant Targets and Active Components of Xiaoyao San

Tian,

Wang,

et al. 2024

Chemistry & Biodiversity

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In recent years, the research of mitochondrial dysfunction in depression has drawn the focus of researchers. Our research group previously found that Xiaoyao San (XYS) has improved the mitochondrial structure and the blocked tricarboxylic acid cycle (TCA cycle) in the hippocampal tissue of chronic unpredictable mild stress (CUMS) rats. However, the specific targets and active components of XYS remain unclear, and the potential to improve hippocampal mitochondrial TCA cycle disorder was also unexplored. In this research, a strategy to combine stable isotope‐resolved metabolomics (SIRM), network pharmacology and transmission electron microscopy (TEM) was used to explore the potential, targets of action, and active components of XYS to improve hippocampal mitochondrial TCA cycle disorder of CUMS rats. The results of TEM showed that the ultrastructure of hippocampal mitochondria could be improved by XYS. A combination of SIRM and molecular docking showed that pyruvate carboxylase (PC), ATP citrate lyase (ACLK), glutamate dehydrogenase (GLDH), glutamate oxaloacetate transaminase (GOT) and pyruvate dehydrogenase (PDH) were targets of XYS to improve TCA cycle disorder. In addition, Troxerutin was found to be the most potential active component of XYS to improve TCA cycle disorder. The above research results can provide new insights for the development of antidepressant drugs.

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A unique insight for Xiaoyao San exerts antidepressant effects by modulating hippocampal glucose catabolism using stable isotope-resolved metabolomics

Cited by 9 publications

References 35 publications

Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems

Stable Isotope Tracer Technique and Network Pharmacology to Reveal Antidepressant Targets and Active Components of Xiaoyao San

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