Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Zhao, Weidi; Ji, Cui; Zheng, Jie; Zhou, Shi; Tian, Junsheng; Han, Yumei; Qin, Xuemei

doi:10.1016/j.chmed.2023.09.004

Chinese Herbal Medicines

2024

DOI: 10.1016/j.chmed.2023.09.004

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Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Weidi Zhao,

Cui Ji,

Jie Zheng

et al.

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Cited by 2 publications

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The role of mitochondrial dynamics in disease

Wang,

Dai,

et al. 2023

MedComm

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Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As dynamic properties of mitochondria, fusion and fission accompanied with mitophagy, undergo constant changes in number and morphology to sustain mitochondrial homeostasis in response to cell context changes. Thus, the dysregulation of mitochondrial dynamics and mitophagy is unsurprisingly related with various diseases, but the unclear underlying mechanism hinders their clinical application. In this review, we summarize the recent developments in the molecular mechanism of mitochondrial dynamics and mitophagy, particularly the different roles of key components in mitochondrial dynamics in different context. We also summarize the roles of mitochondrial dynamics and target treatment in diseases related to the cardiovascular system, nervous system, respiratory system, and tumor cell metabolism demanding high‐energy. In these diseases, it is common that excessive mitochondrial fission is dominant and accompanied by impaired fusion and mitophagy. But there have been many conflicting findings about them recently, which are specifically highlighted in this view. We look forward that these findings will help broaden our understanding of the roles of the mitochondrial dynamics in diseases and will be beneficial to the discovery of novel selective therapeutic targets.

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The role of mitochondrial dynamics in disease

Wang,

Dai,

et al. 2023

MedComm

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Discovery and verification of antidepressant active ingredients of raw and vinegar-processed Bupleurum marginatum var. Stenophyllum based on plant metabolomics and serum pharmacology

Qu,

Bing,

et al. 2024

Journal of Pharmaceutical and Biomedical Analysis

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Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

Cited by 2 publications

References 42 publications

The role of mitochondrial dynamics in disease

The role of mitochondrial dynamics in disease

Discovery and verification of antidepressant active ingredients of raw and vinegar-processed Bupleurum marginatum var. Stenophyllum based on plant metabolomics and serum pharmacology

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